Development of quorum quenchers for the control of multidrug resistant strains
| Project/Area Number |
20590447
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Bacteriology (including Mycology)
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| Research Institution | The University of Tokushima |
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Principal Investigator |
MASEDA Hideaki The University of Tokushima, 大学院・ソシオテクノサイエンス研究部, 准教授 (10372343)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2009: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2008: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | 病原性 / クオラムセンシング機構 / 毒素 / 緑膿菌 / 阻害剤 / クォラムセンシング機構 |
|---|
| Research Abstract |
With the widespread appearance of antibiotic-resistant bacteria, there is an increasing demand for novel strategies to control infectious diseases. The discovery that many bacteria use quorum-sensing (QS) systems to coordinate virulence has pointed out a new, promising target for antimicrobial drugs. We constructed a screening system of QS inhibitor, which enabled us to identify a number of novel QSIs among synthetic 25 compounds by computer modeling. The most active one had inhibited C4-HSL and 3oxoC12-HSL dependent virulences in Pseudomonas aeruginosa specifically and strongly.
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Report
(4 results)
Research Products
(57 results)
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[Presentation] タイ国北部の養魚池における有害藍藻類の発生状況2010
Author(s)
板山朋聡, 岩見徳雄, 清水和也, Niwoot Whangchai, Chayarat Pleumsumran, Sirapran Fakrajang, Suttida Wanno, Ruekeaw Praphrute, Korntip Kammika, 間世田英明, 古澤文章, 杉浦則夫
Organizer
日本水処理生物学会誌, No.30, 26頁
Related Report
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[Presentation] Microcystin分解産物の特性解析2010
Author(s)
清水和也, 星麻里恵, 伊藤聡, 間世田英明, 岡野邦宏, 陳栄志, 内海真生, 張振亜, 杉浦則夫
Organizer
日本水処理生物学会誌,No.30,29頁
Related Report
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