| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2009: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2008: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Research Abstract |
With the widespread appearance of antibiotic-resistant bacteria, there is an increasing demand for novel strategies to control infectious diseases. The discovery that many bacteria use quorum-sensing (QS) systems to coordinate virulence has pointed out a new, promising target for antimicrobial drugs. We constructed a screening system of QS inhibitor, which enabled us to identify a number of novel QSIs among synthetic 25 compounds by computer modeling. The most active one had inhibited C4-HSL and 3oxoC12-HSL dependent virulences in Pseudomonas aeruginosa specifically and strongly.
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