| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2010: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2009: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2008: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Research Abstract |
Pathogenicity of Mycobacterium tuberculosis is closely related to lipid components, present in the cell wall, especially trehalose dimycolate (TDM) which induces formation of pulmonary granuloma during tuberculosis. TDM was emulsified as w/o/w and injected intravenously into C57BL/10ScSn mice. Inflammatory responses were found in lungs at the early stage of TMD injection. IL-17-producing γδ T cells were observed in lung mononuclear cells at the early stage of TMD injection. The infiltration of neutrophils and the number of granulomas was decreased in γδ T cell-depleted mice as compared with control mice at 2 and 7 days after TDM injection. The γδ T cells contribute infiltration of neutrophils into inflammatory sites at the early stage and involved in granuloma formation.
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