| Budget Amount *help |
¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2011: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2010: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2009: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2008: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
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| Research Abstract |
SpiC encoded within Salmonella pathogenicity island 2 on the Salmonella enterica serovar Typhimurium is involved in the expressions of FliC and FimA, which are a component of the flagellar filaments and a major subunit of type 1 fimbriae, respectively. Infection of macrophages with Salmonella causes the increase of intracellular Ca^<2+> levels in a SpiC-dependent manner and the elevation of Ca^<2+> activates the calcium signal transduction pathway, leading to the formation of Salmonella-induced filament that is involved in the intracellular survival of Salmonella.
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