Functional analysis of Salmonella virulence factor involved in survival within host cells and systemic disease
| Project/Area Number |
20590460
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Bacteriology (including Mycology)
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| Research Institution | Meijo University |
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Principal Investigator |
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| Project Period (FY) |
2008 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2011: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2010: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2009: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2008: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
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| Keywords | サルモネラ菌 / SPI-2 / spiC遺伝子 / マクロファージ / 細胞内カルシウムイオン / 細胞内増殖 / 線毛 / FimA / TRL2 / fimA遺伝子 / 鞭毛 / FlhD |
|---|
| Research Abstract |
SpiC encoded within Salmonella pathogenicity island 2 on the Salmonella enterica serovar Typhimurium is involved in the expressions of FliC and FimA, which are a component of the flagellar filaments and a major subunit of type 1 fimbriae, respectively. Infection of macrophages with Salmonella causes the increase of intracellular Ca^<2+> levels in a SpiC-dependent manner and the elevation of Ca^<2+> activates the calcium signal transduction pathway, leading to the formation of Salmonella-induced filament that is involved in the intracellular survival of Salmonella.
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Report
(6 results)
Research Products
(79 results)
