Project/Area Number |
20590462
|
Research Category |
Grant-in-Aid for Scientific Research (C)
|
Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Bacteriology (including Mycology)
|
Research Institution | National Institute of Infectious Diseases |
Principal Investigator |
TERAJIMA Jun National Institute of Infectious Diseases, 細菌第一部, 室長 (70202190)
|
Co-Investigator(Kenkyū-buntansha) |
OHNISHI Makoto 国立感染症研究所, 細菌第一部, 部長 (10233214)
|
Project Period (FY) |
2008 – 2010
|
Project Status |
Completed (Fiscal Year 2010)
|
Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2010: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2009: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2008: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
|
Keywords | 細菌 / 感染症 / シグナル伝達 |
Research Abstract |
To investigate the factors involved in the maintenance of the Shigella infected host cell, one of the secreted effectors, OspE2, was analyzed of its role during the infection. In addition to OspE2, two homologues of OspE2, EspO1-1 and EspO1-2, in enterohaemorrhagic Escherichia coli (EHEC) were also investigated for their roles during infection. The results suggested that these two OspE2 homologues in EHEC also play a role in maintaining the architecture of the infected cells but partly in a different mechanism involving RhoA-Rock signal cascade in the cell.
|