Investigation of Inhibitory effect of Extra-Intestinal Pathogenic Escherichia coli against human neutrophils
| Project/Area Number |
20590463
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Bacteriology (including Mycology)
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| Research Institution | National Institute of Infectious Diseases |
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Principal Investigator |
OHNISHI Makoto National Institute of Infectious Diseases, 細菌第一部, 部長 (10233214)
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| Co-Investigator(Kenkyū-buntansha) |
ATO Manabu 国立感染症研究所, 免疫部, 室長 (20392318)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2010: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2009: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2008: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | 大腸菌 / 好中球 / 病原性 / 腸管外病原性 / 血清耐性 / 補体 / 系統 |
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| Research Abstract |
Molecular mechanism of Extra-Intestinal pathogenic Escherichia coli was investigated. The strain CK17, which is UPEC O2, showed extra high resistant to serum treatment and also resistant to human neutrophils phagocytosis. K1 capsule was responsible to PMN resistant, but not serum resistance. C3 molecule and IgG could not bind K1-produceing CK17. The mechanism of K1-independent serum resistant remains unsolved.
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Report
(4 results)
Research Products
(2 results)
