The role of CM2 ion channel protein in influenza C virus replication and pathogenesis
| Project/Area Number |
20590465
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Virology
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| Research Institution | Yamagata University |
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Principal Investigator |
HONGO Seiji Yamagata University, 医学部, 教授 (90229245)
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| Co-Investigator(Kenkyū-buntansha) |
MURAKI Yasushi 金沢医科大学, 医学部, 准教授 (00241688)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2009: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2008: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | C型インフルエンザウイルス / イオンチャネル / CM2 / 増殖 / 病原性 / イオンチャネル蛋白 |
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| Research Abstract |
Quantification of vRNA in the VLPs by real-time PCR revealed that the CM2-deficient VLPs contain approximately one-third of the vRNA found in wild-type VLPs, suggesting that CM2 is involved in the genome packaging process into VLPs. Furthermore, a smaller amount of vRNA was detected in the nuclear fraction of CM2-deficient VLP-infected cells than in that of wild-type VLP-infected cells, suggesting that the uncoating process of the CM2-deficient VLPs in the infected cells did not proceed in an appropriate manner. Taken together, it is suggested that CM2 has a potential role in the genome packaging and uncoating processes of the virus replication.
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Report
(4 results)
Research Products
(31 results)
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[Journal Article] Cross-antigenicity among EV71 strains from different genogroups isolated in Yamagata, Japan, between 1990 and 2007.2009
Author(s)
Mizuta K, Aoki Y, Suto A, Ootani K, Katsushima N, Itagaki T, Ohmi A, Okamoto M, Nishimura H, Matsuzaki Y, Hongo S, Sugawara K, Shimizu H, Ahiko T
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Journal Title
Vaccine. 27(24)
Pages: 3153-8
Related Report
Peer Reviewed
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[Journal Article] Stability of the seven hexon hypervariable region sequences of adenovirus types 1-6 isolated in Yamagata, Japan between 1988 and 2007.2009
Author(s)
Mizuta K, Matsuzaki Y, Hongo S, Ohmi A, Okamoto M, Nishimura H, Itagaki T, Katsushima N, Oshitani H, Suzuki A, Furuse Y, Noda M, Kimura H, Ahiko T
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Journal Title
Virus Res. 140(1-2)
Pages: 32-9
Related Report
Peer Reviewed
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