Elucidation of the mechanism of virological synapse mediated HTLV-1 infection
| Project/Area Number |
20590468
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Virology
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| Research Institution | Niigata University |
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Principal Investigator |
HIGUCHI Masaya Niigata University, 医歯学系, 准教授 (50334678)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
|
| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2009: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2008: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | 細胞 / 感染 / シグナル伝達 / ウイルス / 感染症 |
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| Research Abstract |
HTLV-1 infection is established through the tight interaction between HTLV-1 infected cells and target cells, so called the virological synapse. In this study, we found that PDZ domain containing cell polarity proteins Dlg1 and MPP7 play a crucial role in the HTLV-1 cell-to-cell infection. We also found that a HTLV-1 receptor GLUT-1 functions through its interaction with PDZ domain containing proteins.
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Report
(4 results)
Research Products
(3 results)
