Elucidation of the mechanism of virological synapse mediated HTLV-1 infection

Research Project

Project/Area Number	20590468
Research Category	Grant-in-Aid for Scientific Research (C)
Allocation Type	Single-year Grants
Section	一般
Research Field	Virology
Research Institution	Niigata University
Principal Investigator	HIGUCHI Masaya Niigata University, 医歯学系, 准教授 (50334678)
Project Period (FY)	2008 – 2010
Project Status	Completed (Fiscal Year 2010)
Budget Amount *help	¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000) Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000) Fiscal Year 2009: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000) Fiscal Year 2008: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Keywords	細胞 / 感染 / シグナル伝達 / ウイルス / 感染症
Research Abstract	HTLV-1 infection is established through the tight interaction between HTLV-1 infected cells and target cells, so called the virological synapse. In this study, we found that PDZ domain containing cell polarity proteins Dlg1 and MPP7 play a crucial role in the HTLV-1 cell-to-cell infection. We also found that a HTLV-1 receptor GLUT-1 functions through its interaction with PDZ domain containing proteins.

Report

(4 results)