Molecular Mechanism of Interaction between the Receptor-binding Protein and Fusion Protein during Membrane Fusion Caused by the Paramyxoviruses
| Project/Area Number |
20590470
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Virology
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| Research Institution | Mie University |
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Principal Investigator |
TSURUDOME Masato 三重大学, 大学院・医学系研究科, 准教授 (50159042)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2010: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2009: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2008: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | パラミクソウイルス / パラインフルエンザウイルス / HN蛋白 / F蛋白 / 受容体 / 細胞融合 / 多核巨細胞 / 蛋白間相互作用 / PIV5 |
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| Research Abstract |
The paramyxoviruses mediate membrane fusion between viral envelope and host cell membrane, which leads to entry of the virus into cells. This membrane fusion is caused by an interaction between the attachment protein and fusion protein on the viral envelope. In the study presented here, I carried out chimeric analysis of the fusion proteins of two paramyxiruseses(PIV5 and SV41) and identified the domains that are required for the fusion protein to interact with the attachment protein.
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Report
(4 results)
Research Products
(43 results)
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[Journal Article] Completion of the full-length genome sequence of human parainfluenza virus types 4 A and 4B : sequence analyses of the large protein genes, and gene start, intergenic and end sequences.2011
Author(s)
Komada H, Kawano M, Uefuji A, Ito M, Tsurudome M, Hatakeyama E, Nakanishi M, Sakue S, Joh S, Suzumura E, Tamaki T, Tomioka T, Nishio M, Tsumura H, Uematsu J, Yamamoto H, O' Brien M, Bando H, and Ito Y.
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Journal Title
Arch. Virol.
Volume: 156
Pages: 161-166
Related Report
Peer Reviewed
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[Journal Article] Fucoidan inhibits parainfluenza virus type 2 infection to LLCMK2 cells2008
Author(s)
Taoda N, Shinji E, Nishii K, Nishioka S, Yonezawa Y, Uematsu J, Hattori E, Yamamoto H, Kawano M, Tsurudome M, O' Brien M, Yamashita T, and Komada H.
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Journal Title
Biomed. Res.
Volume: 29
Pages: 331-334
NAID
Related Report
Peer Reviewed
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