| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2010: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2009: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2008: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Research Abstract |
The paramyxoviruses mediate membrane fusion between viral envelope and host cell membrane, which leads to entry of the virus into cells. This membrane fusion is caused by an interaction between the attachment protein and fusion protein on the viral envelope. In the study presented here, I carried out chimeric analysis of the fusion proteins of two paramyxiruseses(PIV5 and SV41) and identified the domains that are required for the fusion protein to interact with the attachment protein.
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