Pursuit of molecular mechanism and responsible factor for retroviral genome dimerization and recombination.
Project/Area Number |
20590471
|
Research Category |
Grant-in-Aid for Scientific Research (C)
|
Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Virology
|
Research Institution | Osaka University |
Principal Investigator |
SAKURAGI Junichi Osaka University, 微生物病研究所, 助教 (90273705)
|
Project Period (FY) |
2008 – 2010
|
Project Status |
Completed (Fiscal Year 2010)
|
Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2009: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2008: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
|
Keywords | HIV / RNA / 二量体化 / 組換え / パッケージング / ゲノム二量体化 / 逆転写 / ウイルス / 粒子成熟 |
Research Abstract |
We developed the unique systems to analyze retroviral genome dimerization or recombination, and performed the experiment to pursue the nature of HIV genome RNA within virus particles. As a result, we suggested the reasonable evidence that genome dimerization directly controls the genome recombination. As this hypothesis has long been proposed but the direct evidence has not been shown, this data has a great significance. We also unveiled the precise relationship between virion maturation and viral genome maturation process. These results are expected to accelerate analyzing of virion maturation mechanism of HIV-1, which has been largely unclear.
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Report
(4 results)
Research Products
(23 results)