| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2009: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2008: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Research Abstract |
We developed the unique systems to analyze retroviral genome dimerization or recombination, and performed the experiment to pursue the nature of HIV genome RNA within virus particles. As a result, we suggested the reasonable evidence that genome dimerization directly controls the genome recombination. As this hypothesis has long been proposed but the direct evidence has not been shown, this data has a great significance. We also unveiled the precise relationship between virion maturation and viral genome maturation process. These results are expected to accelerate analyzing of virion maturation mechanism of HIV-1, which has been largely unclear.
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