Motility and intelligence of influenza virus
| Project/Area Number |
20590479
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Virology
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| Research Institution | Kawasaki Medical School |
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Principal Investigator |
SAKAI Tatsuya Kawasaki Medical School, 医学部, 助教 (00309543)
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| Co-Investigator(Kenkyū-buntansha) |
ITO Toshihiro 鳥取大学, 農学部, 教授 (00176348)
HIRABAYAHI Jun 産業技術総合研究所, 糖鎖工学センター, 副センター長 (40156691)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2009: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2008: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | 感染防御 / ワクチン / ウイルス / 感染症 / 感染行動 |
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| Research Abstract |
In this research, I demonstrated that Influenza virus has motility and intelligence. Influenza virus moves on a cell surface by exchanging bindings between hemagglutinin and sialoglycan. Avian influenza virus tends not to move backward as an intelligent particle, since viral neuraminidase destroys sialoglycans along a track which the virus particle has moved before. I also demonstrated that virus motion pattern and intelligent level are modified by affinity of hemagglutinin to sialoglycan and enzymatic activity of neuraminidase.
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Report
(4 results)
Research Products
(14 results)
