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Motility and intelligence of influenza virus

Research Project

Project/Area Number 20590479
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Virology
Research InstitutionKawasaki Medical School

Principal Investigator

SAKAI Tatsuya  Kawasaki Medical School, 医学部, 助教 (00309543)

Co-Investigator(Kenkyū-buntansha) ITO Toshihiro  鳥取大学, 農学部, 教授 (00176348)
HIRABAYAHI Jun  産業技術総合研究所, 糖鎖工学センター, 副センター長 (40156691)
Project Period (FY) 2008 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2009: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2008: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Keywords感染防御 / ワクチン / ウイルス / 感染症 / 感染行動
Research Abstract

In this research, I demonstrated that Influenza virus has motility and intelligence. Influenza virus moves on a cell surface by exchanging bindings between hemagglutinin and sialoglycan. Avian influenza virus tends not to move backward as an intelligent particle, since viral neuraminidase destroys sialoglycans along a track which the virus particle has moved before. I also demonstrated that virus motion pattern and intelligent level are modified by affinity of hemagglutinin to sialoglycan and enzymatic activity of neuraminidase.

Report

(4 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report
  • 2008 Annual Research Report
  • Research Products

    (14 results)

All 2011 2010 2009 2008 Other

All Presentation (10 results) Remarks (4 results)

  • [Presentation] インフルエンザウイルスの情報処理能力2011

    • Author(s)
      堺立也
    • Organizer
      日本生物物理学会第3回中国四国支部大会
    • Place of Presentation
      東広島
    • Year and Date
      2011-05-14
    • Related Report
      2010 Final Research Report
  • [Presentation] Infectious behavior of novel influenza A virus.2010

    • Author(s)
      堺立也
    • Organizer
      日本生物物理学会第48回年会
    • Place of Presentation
      仙台
    • Year and Date
      2010-09-20
    • Related Report
      2010 Final Research Report
  • [Presentation] Infectious behavior of novel influenza A virus2010

    • Author(s)
      堺立也
    • Organizer
      日本生物物理学会
    • Place of Presentation
      仙台
    • Year and Date
      2010-09-20
    • Related Report
      2010 Annual Research Report
  • [Presentation] インフルエンザウイルスの感染行動2010

    • Author(s)
      堺立也
    • Organizer
      NLPMコロキウム
    • Place of Presentation
      東広島
    • Year and Date
      2010-06-24
    • Related Report
      2010 Final Research Report
  • [Presentation] インフルエンザウイルスの行動解析2010

    • Author(s)
      堺立也
    • Organizer
      日本生物物理学会第2回中国四国支部大会
    • Place of Presentation
      松山
    • Year and Date
      2010-05-08
    • Related Report
      2010 Final Research Report 2009 Annual Research Report
  • [Presentation] Development of quick imaging technique for analyzing influenza virus behavior.2009

    • Author(s)
      堺立也
    • Organizer
      日本生物物理学会第47回年会
    • Place of Presentation
      徳島
    • Year and Date
      2009-10-31
    • Related Report
      2010 Final Research Report
  • [Presentation] インフルエンザウイルスヘマグルチニン機能の迅速解析技術の開発2008

    • Author(s)
      堺立也
    • Organizer
      日本生物物理学会第46回年会
    • Place of Presentation
      福岡
    • Year and Date
      2008-12-04
    • Related Report
      2010 Final Research Report
  • [Presentation] Development of quick imaging techniques analyzing influenza virus hemagglutinin functions2008

    • Author(s)
      堺立也
    • Organizer
      日本生物物理学会第48回年会
    • Place of Presentation
      福岡
    • Year and Date
      2008-12-04
    • Related Report
      2008 Annual Research Report
  • [Presentation] インフルエンザウイルスの感染行動2008

    • Author(s)
      堺立也
    • Organizer
      日本生物物理学会第1回中国四国支部大会
    • Place of Presentation
      高知
    • Year and Date
      2008-05-10
    • Related Report
      2010 Final Research Report
  • [Presentation] インフルエンザウイルスの感染行動2008

    • Author(s)
      堺立也
    • Organizer
      日本生物物理学会中四国支部大会
    • Place of Presentation
      高知
    • Year and Date
      2008-05-10
    • Related Report
      2008 Annual Research Report
  • [Remarks] ホームページ

    • URL

      http://www.kawasaki-m.ac.jp/microbiology/DeptMB/Home.html

    • Related Report
      2010 Final Research Report
  • [Remarks]

    • URL

      http://www.kawasaki-m.ac.jp/microbiology/Sakai/Home.html

    • Related Report
      2010 Annual Research Report
  • [Remarks]

    • URL

      http://www.kawasaki-m.ac.jp/microbiology/Sakai/Home.html

    • Related Report
      2009 Annual Research Report
  • [Remarks]

    • URL

      http://www.kawasaki-m.ac.jp/microbiology/Sakai/Home.html

    • Related Report
      2008 Annual Research Report

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Published: 2008-04-01   Modified: 2016-04-21  

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