| Project/Area Number |
20590482
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Virology
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| Research Institution | Tokyo Metropolitan Organization for Medical Research |
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Principal Investigator |
KOIKE Satoshi Tokyo Metropolitan Organization for Medical Research, 東京都臨床医学総合研究所, 副参事研究員 (30195630)
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| Co-Investigator(Kenkyū-buntansha) |
YAMAYOSHI Seiya 財団法人東京都医学研究機構, 東京都臨床医学総合研究所, 研究員 (50529534)
ABE Yuko 財団法人東京都医学研究機構, 東京都臨床医学総合研究所, 非常勤研究員 (80398156)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2009: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2008: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | エンテロウイルス71 / ウイルス受容体 / 手足口病 / 脳炎 / 新興・再興感染症 / 種特異性 / 発現クローニング / ウイルス結合部位 / 糖鎖付加 / マイクロアレイ |
|---|
| Research Abstract |
Enterovirus 71 (EV71) is a major causative agent of hand-foot-mouth disease (HFMD) together with Coxsackievirus A16. HFMD caused by EV71 is sometimes involved with severe neurological diseases. We have identified Scavenger receptor B2 (SCARB2) as a cellular receptor for enterovirus 71. SCARB2 serves as receptor for all clinical isolates of EV71 tested. In addition, clinical isolates of CVA16 and CVA14, both of which cause HFMD, are also able to infect in a SCARB2-dependent pathway. We also identified that the 64 amino acid region in the human SCARB2 is essential for binding to EV71 and establishment of infection.
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