| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2010: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2009: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2008: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Research Abstract |
We show that memory Th2 cells are subdivided into at least four subpopulations by CD62L and CXCR3 expression. All four subpopulations produced IL-4 and IL-13 upon TCR-mediated re-stimulation, while only CD62L-low/CXCR3-low population produced IL-5. We performed a DNA microarray analysis and found that CD62L-low/CXCR3-low subpopulation expressed osteopontin, IL-6, and IL-10. We speculate that CD62L-low/CXCR3-low memory Th2 cells may therapeutic target for allergic disorders. We screened low molecular weight compounds and found that synthetic thioamide-related compound SH-2251 inhibited the generation of IL-5 producing memory Th2 cells as well as IL-5 production. Furthermore, SH-2251 also inhibited osteopontin, IL-6, and IL-10 expression. These results indicate that SH-2251 may modulateCD62L-low/CXCR3-low memory Th2 cell functions.
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