Analysis of TEC progenitors and their niche in the adult thymi
| Project/Area Number |
20590495
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Immunology
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| Research Institution | Meiji College of Oriental Medicine |
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Principal Investigator |
ITOI Manami Meiji College of Oriental Medicine, 医学教育研究センター, 准教授 (00257833)
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| Co-Investigator(Kenkyū-buntansha) |
AMAGAI Takashi 明治国際医療大学, 医学教育研究センター, 教授 (80094407)
TSUKAMOTO Noriyuki 明治国際医療大学, 医学教育研究センター, 講師 (80319524)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2009: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2008: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | 発生・分化 / 細胞・組織 / 再生医学 / Foxn1 / 免疫学 / 再生医療 |
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| Research Abstract |
To identify the thymic epithelial progenitor cells and their niche in the adult thymi, we analyzed the phenotypes of proliferating epithelial cells and their distribution in the post-natal thymi. Our results suggest that Foxn1-positive cell population includes cortical and medullary epithelial progenitor cells, and they distribute in the medulla of the adult thymi though they exist in the specific regions of the cortex and the medulla in the newborn thymi.
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Report
(4 results)
Research Products
(41 results)
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[Journal Article] Thymic cysts originate from Foxn1 positive thymic medullary epithelium.2010
Author(s)
Vroegindeweij E, Crobach S, Itoi M, Satoh R, Zuklys S, Happe C, Germeraad WT, Cornelissen JJ, Cupedo T, Hollander GA, Kawamoto H, van Ewijk W
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Journal Title
Mol Immunol. 47(5)
Pages: 1106-1113
Related Report
Peer Reviewed
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