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Analysis of TEC progenitors and their niche in the adult thymi

Research Project

Project/Area Number 20590495
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Immunology
Research InstitutionMeiji College of Oriental Medicine

Principal Investigator

ITOI Manami  Meiji College of Oriental Medicine, 医学教育研究センター, 准教授 (00257833)

Co-Investigator(Kenkyū-buntansha) AMAGAI Takashi  明治国際医療大学, 医学教育研究センター, 教授 (80094407)
TSUKAMOTO Noriyuki  明治国際医療大学, 医学教育研究センター, 講師 (80319524)
Project Period (FY) 2008 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2009: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2008: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Keywords発生・分化 / 細胞・組織 / 再生医学 / Foxn1 / 免疫学 / 再生医療
Research Abstract

To identify the thymic epithelial progenitor cells and their niche in the adult thymi, we analyzed the phenotypes of proliferating epithelial cells and their distribution in the post-natal thymi. Our results suggest that Foxn1-positive cell population includes cortical and medullary epithelial progenitor cells, and they distribute in the medulla of the adult thymi though they exist in the specific regions of the cortex and the medulla in the newborn thymi.

Report

(4 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report
  • 2008 Annual Research Report
  • Research Products

    (41 results)

All 2011 2010 2009 2008 Other

All Journal Article (15 results) (of which Peer Reviewed: 15 results) Presentation (25 results) Remarks (1 results)

  • [Journal Article] Polycomb group gene Bmi1 plays a role in the growth of thymic epithelial cells.2011

    • Author(s)
      Guo Y, Miyazaki M, Itoi M, Satoh R, Iwama A, Amagai T, Kawamoto H, Kanno M
    • Journal Title

      Eur J Immunol. 41(4)

      Pages: 1098-1107

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Thymic cysts originate from Foxn1 positive thymic medullary epithelium.2010

    • Author(s)
      Vroegindeweij E, Crobach S, Itoi M, Satoh R, Zuklys S, Happe C, Germeraad WT, Cornelissen JJ, Cupedo T, Hollander GA, Kawamoto H, van Ewijk W
    • Journal Title

      Mol Immunol. 47(5)

      Pages: 1106-1113

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Foxn1 is essential for vascularization of the murine thymus anlage.2010

    • Author(s)
      Mori K, Itoi M, Tsukamoto N, Amagai T
    • Journal Title

      Cell Immunol. 260

      Pages: 66-69

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Moxibustion activates host defense against herpes simplex virus type 1 through augmentation of cytokine production.2010

    • Author(s)
      Takayama Yuko
    • Journal Title

      Microbiology and Immunology

      Volume: 54 Pages: 551-557

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Differentiation of pharyngeal endoderm and derivatives from mouse Embryonic stem cells.2010

    • Author(s)
      Hidaka Kyoko
    • Journal Title

      Stem Cells and Development

      Volume: 19(11) Pages: 1735-1743

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Differentiation of pharyngeal endoderm and derivatives from mouse embryonic stem cells2010

    • Author(s)
      Hidaka Kyoko
    • Journal Title

      Stem Cells and Development (In press)

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Declining expression of a single epithelial cell-autonomous gene accelerates age-related thymic involution2010

    • Author(s)
      Sun Liguang
    • Journal Title

      Aging Cell 9

      Pages: 347-357

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Postnatal tissue-specific disruption of transcription factor FoxN1 triggers acute thymic atrophy2010

    • Author(s)
      Cheng Lili
    • Journal Title

      The Journal of Biological Chemistry 285

      Pages: 5836-5847

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Foxn1 is essential for vascularization of the murine thymus anlage2010

    • Author(s)
      Mori Kazuya
    • Journal Title

      Cellular Immunology 260

      Pages: 66-69

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Thymic cysts originates from Foxn1 positive thymic medullary epithelium2010

    • Author(s)
      Vroegindeweij Eric
    • Journal Title

      Molecular Immunology 47(5)

      Pages: 1106-1113

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Notch activation in thymic epithelial cells induced development of thymic microenvironments.2009

    • Author(s)
      Masuda K, Germeraad WT, Satoh R, Itoi M, Ikawa T, Minato N, Katsura Y, van Ewijk W, Kawamoto H
    • Journal Title

      Mol Immunol. 46(8-9)

      Pages: 1756-1767

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Notch activation in thymic epithelial cells induced development of thymic microenvironments2009

    • Author(s)
      Kyoko Masuda
    • Journal Title

      Molecular Immunology 46

      Pages: 1756-1767

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Stabilized beta-catenin in thymic epithelial cells blocks thymus development and function2009

    • Author(s)
      Saulius Zuklys
    • Journal Title

      Journal of Immunology 182

      Pages: 2997-3007

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Gene expression profile of the third pharyngeal pouch reveals role of mesenchymal MafB in embryonic thymus development2009

    • Author(s)
      Dil Afroz Sultana
    • Journal Title

      Blood 113

      Pages: 2976-2987

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Neural crest origin of perivascular mesenchyme in the adult thymus2008

    • Author(s)
      Susanna M. Muller
    • Journal Title

      Journal of Immunology 180

      Pages: 5344-5351

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Presentation] Foxn1 is differentially required for cTEC and mTEC function.2011

    • Author(s)
      糸井マナミ
    • Organizer
      EUThyme-Rolduc Meeting.
    • Place of Presentation
      Leeuwenhorst, NL.
    • Year and Date
      2011-05-22
    • Related Report
      2010 Final Research Report
  • [Presentation] 胸腺皮質および髄質上皮細胞の分化における転写因子Foxn1の役割2011

    • Author(s)
      糸井マナミ
    • Organizer
      日本胸腺研究会
    • Place of Presentation
      長崎
    • Year and Date
      2011-02-05
    • Related Report
      2010 Final Research Report
  • [Presentation] 胸腺皮質および髄質上皮細胞の分化における転写因子Foxnlの役割2011

    • Author(s)
      糸井マナミ
    • Organizer
      日本胸腺研究会
    • Place of Presentation
      長崎、長崎大学医学部良順会館
    • Year and Date
      2011-02-05
    • Related Report
      2010 Annual Research Report
  • [Presentation] Foxn1 is differently required for the cortical and medullary epithelial cell development.2010

    • Author(s)
      糸井マナミ
    • Organizer
      The 2^<nd> Synthetic immunology Workshop.
    • Place of Presentation
      Kyoto
    • Year and Date
      2010-12-17
    • Related Report
      2010 Final Research Report
  • [Presentation] Foxnl is differently required for the cortical and medullary epithelial cell development2010

    • Author(s)
      Itoi Manami
    • Organizer
      The 2^<nd> Synthetic immunology Workshop
    • Place of Presentation
      京都、芝蘭会館
    • Year and Date
      2010-12-17
    • Related Report
      2010 Annual Research Report
  • [Presentation] A Niche for Natural Regulatory T Cells provides TGFβ Signal in the Thymus2010

    • Author(s)
      Amagai Takashi
    • Organizer
      14^<th> International Congress of Immunology
    • Place of Presentation
      神戸、神戸国際展示場
    • Year and Date
      2010-08-25
    • Related Report
      2010 Annual Research Report
  • [Presentation] Defect in T lineage cell emigration from the thymi of CTS mice2010

    • Author(s)
      Noriyuki Tsukamoto
    • Organizer
      14^<th> International Congress of Immunology
    • Place of Presentation
      神戸、神戸国際展示場
    • Year and Date
      2010-08-24
    • Related Report
      2010 Annual Research Report
  • [Presentation] The role of Foxn1 in the mature epithelial cells and epithelial progenitor cells in the postnatal thymi.2010

    • Author(s)
      糸井マナミ
    • Organizer
      14^<th> International Congress of Immunology.
    • Place of Presentation
      Kobe
    • Year and Date
      2010-08-23
    • Related Report
      2010 Final Research Report
  • [Presentation] The role of Foxnl in the mature epithelial cells and epithelial progenitor cells in the postnatal thymi2010

    • Author(s)
      Itoi Manami
    • Organizer
      14^<th> International Congress of Immunology.
    • Place of Presentation
      神戸、神戸ポートピアホテル
    • Year and Date
      2010-08-23
    • Related Report
      2010 Annual Research Report
  • [Presentation] Newly generated host derived endothelial cells create thymus specific vascular network in the grafted thymus2010

    • Author(s)
      Wada Kumiko
    • Organizer
      14^<th> International Congress of Immunology.
    • Place of Presentation
      神戸、神戸国際展示場
    • Year and Date
      2010-08-23
    • Related Report
      2010 Annual Research Report
  • [Presentation] The function of Biml in the thymic epithelial cells2010

    • Author(s)
      Guo Yun
    • Organizer
      14^<th> International Congress of Immunology
    • Place of Presentation
      神戸、神戸国際展示場
    • Year and Date
      2010-08-23
    • Related Report
      2010 Annual Research Report
  • [Presentation] 胸腺皮質上皮細胞分化と機能発現におけるFoxn1の役割2010

    • Author(s)
      糸井マナミ
    • Organizer
      第21回京都T細胞カンファレンス
    • Place of Presentation
      京都
    • Year and Date
      2010-06-10
    • Related Report
      2010 Final Research Report
  • [Presentation] 移植胸腺に形成されるレシピエント由来血管は胸腺特異的血管として機能する2010

    • Author(s)
      和田久美子
    • Organizer
      京都T細胞カンファレンス
    • Place of Presentation
      京都、芝蘭会館
    • Year and Date
      2010-06-04
    • Related Report
      2010 Annual Research Report
  • [Presentation] The role of Foxn1 in mature epithelial cells and epithelial progenitor cells in the postnatal thymi.2010

    • Author(s)
      糸井マナミ
    • Organizer
      ThymOzVI : An International Workshop on T Lymphocytes.
    • Place of Presentation
      Heron Island. Australia
    • Year and Date
      2010-03-19
    • Related Report
      2010 Final Research Report
  • [Presentation] The role of FoxN1 in the mature epithelial cells and epithelial progenitor cells in the postnatal thymi2010

    • Author(s)
      Manami Itoi
    • Organizer
      ThymOzVI An International Workshop on T Lymphocytes
    • Place of Presentation
      Heron Island, Australia
    • Year and Date
      2010-03-19
    • Related Report
      2009 Annual Research Report
  • [Presentation] Newly generated host-derived endothelial cells create thymus specific vascular networks in grafted thymus2010

    • Author(s)
      Takashi Amagai
    • Organizer
      ThymOzVI An International Workshop on T Lymphocytes
    • Place of Presentation
      Heron Island, Australia
    • Year and Date
      2010-03-18
    • Related Report
      2009 Annual Research Report
  • [Presentation] Production and activation of transforming growth factor-ss in the thymus for development of natural regulatory T cells2009

    • Author(s)
      Daisuke Morishita
    • Organizer
      第39日本免疫学会
    • Place of Presentation
      大阪、大阪国際会護場
    • Year and Date
      2009-12-03
    • Related Report
      2009 Annual Research Report
  • [Presentation] Foxn1 expression in proliferating epithelial cells in the postnatal mouse thymus.2009

    • Author(s)
      糸井マナミ
    • Organizer
      Proceedings of the Japanese Society for Immunology.
    • Place of Presentation
      Osaka
    • Year and Date
      2009-12-02
    • Related Report
      2010 Final Research Report
  • [Presentation] Foxn1 expression in proliferating epithelial cells in the postnatal mouse thymus2009

    • Author(s)
      Manami Itoi
    • Organizer
      第39日本免疫学会
    • Place of Presentation
      大阪、大阪国際会議場
    • Year and Date
      2009-12-02
    • Related Report
      2009 Annual Research Report
  • [Presentation] Characterization of Foxn1-positive cells in the postnatal mouse thymus.2009

    • Author(s)
      糸井マナミ
    • Organizer
      The 5^<th> International Workshop of Kyoto T Cell Conference.
    • Place of Presentation
      Kyoto
    • Year and Date
      2009-06-02
    • Related Report
      2010 Final Research Report
  • [Presentation] Characterization of Foxn1-positive cells in the postnatal mouse thymus2009

    • Author(s)
      Manami Itoi
    • Organizer
      The 5^<th> International Workshop of Kyoto T Cell Conference
    • Place of Presentation
      京都、芝蘭会館
    • Year and Date
      2009-06-02
    • Related Report
      2009 Annual Research Report
  • [Presentation] Defects in mature thymocyte emigration in the thymus of CTS mice2008

    • Author(s)
      Noiyuki Tsukamoto
    • Organizer
      第38回日本免疫学会
    • Place of Presentation
      京都、国立京都国際会館
    • Year and Date
      2008-12-02
    • Related Report
      2008 Annual Research Report
  • [Presentation] Lymphocyte-dependent and independent differentiation of cortical epithelial cells2008

    • Author(s)
      Manami Itoi
    • Organizer
      ThymUS 2008
    • Place of Presentation
      San Juan, Puerto Rico
    • Year and Date
      2008-11-10
    • Related Report
      2008 Annual Research Report
  • [Presentation] Initiation of T progenitor cell migration into the Thymus via blood vessels2008

    • Author(s)
      Takashi Amagai
    • Organizer
      ThymUS 2008
    • Place of Presentation
      San Juan, Puerto Rico
    • Year and Date
      2008-11-10
    • Related Report
      2008 Annual Research Report
  • [Presentation] 胸腺の血管を介するT前駆細胞の胸腺内移動2008

    • Author(s)
      Manami Itoi
    • Organizer
      The 18^<th> Kyoto T Cell Conference
    • Place of Presentation
      京都、芝蘭会館
    • Year and Date
      2008-06-14
    • Related Report
      2008 Annual Research Report
  • [Remarks] ホームページ等

    • URL

      http://www.meiji-u.ac.jp/faculty/dep_immu/index.html

    • Related Report
      2010 Final Research Report

URL: 

Published: 2008-04-01   Modified: 2016-04-21  

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