MAP3K regulation of immune cell development and function

• Project/Area Number: 20590496
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Immunology
• Research Institution: The Institute of Physical and Chemical Research
• Principal Investigator: SHINOHARA Hisaaki The Institute of Physical and Chemical Research, 分化制御研究グループ, 研究員 (10391971)
• Project Period (FY): 2008 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000); Fiscal Year 2010: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2009: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2008: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
• Keywords: NF-kappaB / MAP3K / シグナル伝達 / NF-κB / 獲得免疫 / 抗原受容体

Research Abstract

MAP3K, TAK1 is shared in adaptive and innate immune signaling. We generated and analyzed B cell conditional deletion of TAK1 using mb1-cre. In periphery, TAK1-deficient B cells showed impaired activation of NF-kB, proliferation, survival, and diffrentiation induced by anti-IgM. TAK-deficient bone marrow B cell also showed significant decreased differentiation in some subsets. Thus these analysis suggest TAK1 is essential for B cell differentiation.

Research Products

• [Journal Article] Dephosphorylation of Carma1 by PP2A negatively regulates T cell activation (2011)
  • Author(s): Eitelhuber A C., Warth S., Schimmack G., Duwel M., Hadian K., Demski K., Beisker W., Shinohara H., Kurosaki T., Heissmeyer V., Krappmann D.
  • Journal Title: EMBO J 30(3) Pages: 594-605
  • Peer Reviewed
• [Journal Article] B cell signaling and fate decision. (2010)
  • Author(s): Kurosaki T., Shinohara H., Baba Y.
  • Journal Title: Ann Rev Immunol. 28 Pages: 21-55
• [Journal Article] MAGUK-controlled ubiquitination of CARMA1 modulates lymphocyte NF-κB activity. (2010)
  • Author(s): Moreno-Garcia M.E., Sommer K., Shinohara H., Bandaranayake A.D, Kurosaki T., Rawlings D.J.
  • Journal Title: Mol Cell Biol. 30(4) Pages: 922-934
  • Peer Reviewed
• [Journal Article] Comprehending the Complex Connection between PKCβ, TAK1, and IKK in BCR-signaling. (2009)
  • Author(s): Shinohara H., Kurosaki T.
  • Journal Title: Immunol Rev. 232 Pages: 300-318
• [Journal Article] Regulation of NF-κB-dependent T cell activation and development by MEKK3. (2009)
  • Author(s): Shinohara H., Yamasaki S., Maeda S., Saito T., Kurosaki T.
  • Journal Title: Int.Immunol. 21(4) Pages: 393-401
  • NAID: 10025385463
  • Peer Reviewed
• [Journal Article] Comprehending the Complex Connection between PKCβ, TAK1, and IKK in BCR-signaling (2009)
  • Author(s): Shinohara, H., Kurosaki T.
  • Journal Title: Immunological Review 232 Pages: 300-318
• [Journal Article] PLCγ2 and Vav cooperate within 'microsignalosomes' to propagate B cell spreading in response to membrane-bound antigen. (2008)
  • Author(s): Weber M., Treanor B, Depoil D., Shinohara H., Harwood N.E., Hikida M., Kurosaki T, Batista F.D.
  • Journal Title: J Exp Med. 205 Pages: 853-68
  • Peer Reviewed
• [Journal Article] PLCγ2 and Vav cooperate within 'microsignalosomes' to propagate B cell spreading in response to membrane-bound antigen (2008)
  • Author(s): Weber M., et al.
  • Journal Title: J Exp Med. 205 Pages: 853-868
  • Peer Reviewed
• [Journal Article] Dephosphorylation of Carma1 by PP2A negatively regulates T-cell activation.
  • Author(s): Eitelhuber AC
  • Journal Title: EMBO J. Volume: (印刷中)
  • Peer Reviewed
• [Journal Article] B cell signaling and fate decision
  • Author(s): Kurosaki T., Shinohara H., Baba Y.
  • Journal Title: Annual Review of Immunology (in press)
• [Journal Article] MAGUK-controlled ubiquitination of CARMA1 modulates lymphocyte NF-κB activity
  • Author(s): Moreno-Garcia M.E., Sommer K., Shinohara H., et al.
  • Journal Title: Molecular and Cellular Biology (in press)
  • Peer Reviewed
• [Journal Article] Regulation of NF-κB-dependent T cell activation and development by MEKK3
  • Author(s): Shinohara, H., et al.
  • Journal Title: International Immunology
  • NAID: 10025385463
  • Peer Reviewed