| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2010: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2009: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2008: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Research Abstract |
I am investigating the role of Zn of mast cells in allergy. I am analyzing in role of zinc transporters in mast cell-mediated allergic reactions. We found that a Zn transporter, Znt5/Slc30a5 is required for Fc epsilon RI-mediated cytokine production, but not degranulation. As a result, Znt5-/- mice had defects in mast cell-mediated delayed-type allergic reactions but not in the immediate-type reaction. Znt5 was required for Fc epsilon RI-induced translocation of PKC to the plasma membrane and the nuclear translocation of NF-kappa B. Thus, Zinc transporter Znt5 is selectively required for mast cell-mediated delayed-type allergic responses, and is a novel player in PKC signaling.
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