Functional analysis of memory B cells in lungs
Project/Area Number |
20590501
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Immunology
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Research Institution | National Institute of Infectious Diseases |
Principal Investigator |
TAKAHASHI Yoshimasa National Institute of Infectious Diseases, 免疫部, 室長 (60311403)
|
Project Period (FY) |
2008 – 2010
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Project Status |
Completed (Fiscal Year 2010)
|
Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2010: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2009: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2008: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
|
Keywords | 免疫記憶 / インフルエンザ / B細胞 |
Research Abstract |
Lung memory B cells exhibited the increased maturity and conferred protection against re-infected viruses by producing robust numbers of IgA-secreting plasma cells. Lung memory B cells showed the similar gene expression profile with those in secondary lymphoid organs, but several genes were selectively upregulated in lung memory B cells. Gene-deficient mice were generated to define in vivo function of one of those genes.
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Report
(4 results)
Research Products
(49 results)
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[Journal Article] CD22 expression mediates the regulatory functions of peritoneal B-la cells during the remission phase of contact hypersensitivity reactions.2010
Author(s)
Nakashima H., Hamaguchi Y., Watanabe R., Ishiura N., Kuwano Y., Okochi H., Takahashi Y., Tamaki K., Sato S., Tedder T. F., Fujimoto M.
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Journal Title
J.Immuno. 184
Pages: 637-4645
Related Report
Peer Reviewed
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