Identification of effective supportive care for cancer patients undergoing chemotherapy on evidence-based QOL assessment

• Project/Area Number: 20590516
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Medical sociology
• Research Institution: Nagoya City University
• Principal Investigator: KOMATSU Hirokazu 名古屋市立大学, 大学院・医学研究科, 准教授 (60336675)
• Co-Investigator(Renkei-kenkyūsha): IIDA Shinsuke 名古屋市立大学, 大学院・医学研究科, 准教授 (50295614) ; KUSUMOTO Shigeru 名古屋市立大学, 大学院・医学研究科, 講師 (90423855)
• Project Period (FY): 2008 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000); Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2009: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2008: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
• Keywords: QOL / がん / 薬物療法 / 医療の質(QOL) / 癌(がん)

Research Abstract

Individual-based management including anticipatory nausea has been shown to be critical for anti-emetic therapy in ambulatory cancer patients undergoing chemotherapy. Early oral health care can be effective for the management of chemotherapy-induced stomatitis. Skin damage by chemotherapy and molecular-targeted therapy should be managed prophylactically by the multi-disciplinary medicine. Nurses in outpatient chemotherapy center may have difficulty in assessing their patients'symptoms and supportive care needs. The total supports for their family should be essential as well as patients. Psycho-oncology, patients' education and home health care will be next focused issues.

Research Products

• [Journal Article] Anticipatory nausea among ambulatory cancerpatients undergoing chemotherapy : Prevalence, associated factors, and impact on quality of life (2010)
  • Author(s): Tatsuo Akechi, Hirokazu Komatsu, et al
  • Journal Title: Cancer Sci Pages: 102596-2600
• [Journal Article] Anticipatory nausea among ambulatory cancer patients undergoing chemotherapy : prevalence, associated factors, and impact on quality of life. (2010)
  • Author(s): Akechi T, Komatsu H, et al
  • Journal Title: Cancer Sci. Volume: 101 Pages: 2596-2600
  • NAID: 10027834647
  • Peer Reviewed
• [Journal Article] A complement-dependent cytotoxicity-enhancing anti-CD20 antibody mediating potent antitumor activity in the humanized NOD/Shi-scid, IL-2Rγ(null) mouse lymphoma model. (2010)
  • Author(s): Sato F, Komatsu H, et al
  • Journal Title: Cancer Immunol Immunother. Volume: 59 Pages: 1791-1800
  • Peer Reviewed
• [Journal Article] Bortezomib-resistant myeloma cell lines : a role for mutated PSMB5 in preventing the accumulation of unfolded proteins and fatal ER stress. (2010)
  • Author(s): Ri M, Komatsu H, et al
  • Journal Title: Leukemia. Volume: 24 Pages: 1506-1512
  • Peer Reviewed
• [Journal Article] 日本内科学会雑誌腫瘍内科の現状と展開腫瘍内科の育成と役割がん医療における腫瘍内科の役割 (2009)
  • Author(s): 楠本茂、小松弘和, 他
  • Journal Title: 日本内科学会雑誌 Volume: 98 Pages: 1947-1951
• [Journal Article] Defucosylated anti-CCR4 monoclonal antibody exerts potent ADCC against primary ATLL cells mediated by autologous human immune cells in NOD/Shi-scid, IL-2R gamma(null)mice in vivo (2009)
  • Author(s): Ito A, Komatsu H, et al
  • Journal Title: J Immunol. 183 Pages: 4782-4791
  • Peer Reviewed
• [Journal Article] Expression of the ULBP ligands for NKG2D by B-NHL cells plays an important role in determining their susceptibility to rituximab-induced ADCC (2009)
  • Author(s): Inagaki A, Komatsu H, et al
  • Journal Title: Int J Cancer 125 Pages: 212-221
  • Peer Reviewed
• [Journal Article] Defucosylated anti-CCR4 monoclonal antibody exercises potent ADCC-mediated antitumor effect in the novel tumor-bearing humanized NOD/Shi-scid, IL-2Rgamma(null)mouse model (2009)
  • Author(s): Ito A, Komatsu H, et al
  • Journal Title: Cancer Immunol Immunother 58 Pages: 1195-1206
  • Peer Reviewed
• [Journal Article] Bortezomib-induced apoptosis in mature T-cell lymphoma cells partially depends on upregulation of Noxa and functional repres sion of Mcl-1. (2009)
  • Author(s): Ri M, Komatsu H, et al
  • Journal Title: Cancer Sci. 100 Pages: 341-348
  • Peer Reviewed
• [Journal Article] Overexpression of carboxylesterase-2 results in enhanced efficacy of topoisomerase l inhibitor, irinotecan (CPT-11), for mul tiple myeloma. (2008)
  • Author(s): Yano H, Komatsu H, et al
  • Journal Title: Cancer Sci. 99 Pages: 2309-2314
  • Peer Reviewed
• [Presentation] 大腸がんにおけるXELOX療法の手足症候群対策マニュアルの運用とその検証 (2010)
  • Author(s): 辻かおり、小松弘和, ほか
  • Organizer: 第48回日本癌治療学会学術集会
  • Place of Presentation: 京都(国立京都国際会館)
  • Year and Date: 2010-10-29
• [Presentation] 多職種連携による治療・ケアを目的とした「セツキシマブ皮膚症状対策マニュアル」 (2010)
  • Author(s): 近藤勝弘、小松弘和, 他
  • Organizer: 作成と薬剤師による患者指導に関する検討日本臨床腫瘍学会学術集会
  • Place of Presentation: 東京
• [Presentation] 抗がん剤による血管外漏出のリスク因子 (2010)
  • Author(s): 春田真弓、小松弘和, 他
  • Organizer: 日本臨床腫瘍学会学術集会
  • Place of Presentation: 東京
• [Presentation] 抗体医薬品開発の現状 (2009)
  • Author(s): 小松弘和
  • Organizer: 第13回日本分子標的治療学会学術集会
  • Place of Presentation: ホテルクレメント徳島(徳島市)
  • Year and Date: 2009-06-25
• [Presentation] B細胞性リンパ腫におけるCHASER療法の安全性と末梢血幹細胞採取の有効性について (2008)
  • Author(s): 小松弘和, 他
  • Organizer: 第70回日本血液学会総会
  • Place of Presentation: 京都
  • Year and Date: 2008-10-12
• [Book] 日本臨床 特集 固形癌の最新治療 抗体医薬 (2010)
  • Author(s): 小松弘和
  • Total Pages: 9
  • Publisher: 日本臨床社
• [Book] 日本内科学会雑誌 腫瘍内科の現状と展開腫瘍内科の育成と役割 がん医療における腫瘍内科の役割 (2009)
  • Author(s): 楠本茂, 小松弘和, 他
  • Total Pages: 4
  • Publisher: 日本内科学会
• [Remarks]
  • URL: http://www.med.nagoya-cu.ac.jp/inter2.dir/indexJ.htm