Clarify the molecular mechanisms of the induction of apoptosis by the highly active nucleosides
Project/Area Number |
20590533
|
Research Category |
Grant-in-Aid for Scientific Research (C)
|
Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Applied pharmacology
|
Research Institution | Tohoku University |
Principal Investigator |
SATO Takeya Tohoku University, 大学院・医学系研究科, 助教 (10312696)
|
Co-Investigator(Kenkyū-buntansha) |
YANAGISAWA Teruyuki 東北大学, 大学院・医学系研究科, 教授 (90133941)
SUKEGAWA Jun 東北大学, 大学院・医学系研究科, 准教授 (30187687)
|
Project Period (FY) |
2008 – 2010
|
Project Status |
Completed (Fiscal Year 2010)
|
Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2010: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2009: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2008: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
|
Keywords | 遺伝子 / 癌 / 生体機能利用 / トランスレーショナルリサーチ / 薬剤反応性 |
Research Abstract |
Bystander effect was observed in the non-gene modified cells adjacent to the gene modified cells expressing tmpk-variants treated with nontoxic dose of AZT against the normal cells. GJIC formed between these cells are crucial to exhibit the effect. These results suggest that our tmpk/AZT approach is feasible to use for the anti-cancer gene therapy.
|
Report
(4 results)
Research Products
(29 results)
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[Journal Article] Vezatin, a potential target for ADP-ribosylation factor 6, regulates the dendritic formation of hippocampal neurons.2010
Author(s)
Sanda M, Ohara N, Kamata A, Hara Y, Tamaki H, Sukegawa J, Yanagisawa T, Fukunaga K, Kondo H, Sakagami H.
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Journal Title
Neurosci Res.
Volume: 67
Pages: 126-136
Related Report
Peer Reviewed
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[Journal Article] Direct injection of kit ligand-2 lentivirus improves cardiac repair and rescues mice post-myocardial infarction.2009
Author(s)
Higuchi K, Ayach B, Sato T, Chen M, Devine SP, Rasaiah VI, Dawood F, Yanagisawa T, Tei C, Takenaka T, Liu PP, Medin JA.
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Journal Title
Mol Ther. 17(2)
Pages: 262-268
Related Report
Peer Reviewed
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[Journal Article] Direct Injection of Kit Ligand-2 Lentivirus Improves Cardiac Repair and Rescues Mice Post-myocardial Infarction2009
Author(s)
Higuchi K, Ayach B, Sato T, Chen M, Devine SP, Rasaiah VI, Dawood F, Yanagisawa T, Tei C, Takenaka T, Liu PP, Medin JA
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Journal Title
Molecular Theapy 17(2)
Pages: 262-268
Related Report
Peer Reviewed
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[Journal Article] CLIC4 interacts with histamine H3 receptor and enhances the receptor cell surface expression.2008
Author(s)
Maeda K, Haraguchi M, Kuramasu A, Sato T, Ariake K, Sakagami H, Kondo H, Yanai K, Fukunaga K, Yanagisawa T, Sukegawa J.
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Journal Title
Biochem Biophys Res Commun. 369(2)
Pages: 603-608
Related Report
Peer Reviewed
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[Journal Article] CLIC4 interacts with histamine H3 receptor and enhances the receptor cell surface expression2008
Author(s)
Maeda K, Haraguchi M, Kuramasu A, Sato T, Ariake K, Sakagami H, Kondo H, Yanai K, Fukunaga K, Yanagisawa T, Sukegawa J
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Journal Title
Biochem Biophys Res Commun 369(2)
Pages: 603-608
Related Report
Peer Reviewed
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