| Project/Area Number |
20590540
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Applied pharmacology
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| Research Institution | Kumamoto University |
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Principal Investigator |
IRIE Tetsumi Kumamoto University, 大学院・生命科学研究部, 教授 (60150546)
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| Co-Investigator(Kenkyū-buntansha) |
ISHITSUKA Youichi 熊本大学, 大学院・生命科学研究部, 助教 (70423655)
TAKAHAMA Kazuo 熊本大学, 大学院・生命科学研究部, 教授 (80150548)
ANDO Yukio 熊本大学, 大学院・生命科学研究部, 教授 (20253742)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2009: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2008: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
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| Keywords | アミノフィリン / 中枢神経傷害 / 医薬品副作用 / 新生児医療 / 呼吸興奮薬 / 薬物有害事象 |
|---|
| Research Abstract |
Aminophylline, a hydrophilic methylxanthine derivative, is often used to treat patients with apnea of prematurity to prevent further respiratory impairment in Japan. We showed that aminophylline, used at recommended doses, aggravated neuronal injury as indicated by increased serum CK-BB activity, a reduction in the number of cells in the hippocampal CA1 region, and increased lipid peroxide levels and a decreased GSH:GSSG ratio in brain tissue under hypoxic conditions induced by low-tidal volume ventilation in guinea pigs. We also showed that these effects were attenuated by treatment with the free radical scavenger, edaravone. The results suggest that aminophylline treatment aggravates the central nervous system of patients with hypoxemia.
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