Aminophylline induced-neuronal cell injury under hypoxic conditions and the survey of the protective agents against the injury.
| Project/Area Number |
20590540
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Applied pharmacology
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| Research Institution | Kumamoto University |
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Principal Investigator |
IRIE Tetsumi Kumamoto University, 大学院・生命科学研究部, 教授 (60150546)
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| Co-Investigator(Kenkyū-buntansha) |
ISHITSUKA Youichi 熊本大学, 大学院・生命科学研究部, 助教 (70423655)
TAKAHAMA Kazuo 熊本大学, 大学院・生命科学研究部, 教授 (80150548)
ANDO Yukio 熊本大学, 大学院・生命科学研究部, 教授 (20253742)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2009: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2008: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
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| Keywords | アミノフィリン / 中枢神経傷害 / 医薬品副作用 / 新生児医療 / 呼吸興奮薬 / 薬物有害事象 |
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| Research Abstract |
Aminophylline, a hydrophilic methylxanthine derivative, is often used to treat patients with apnea of prematurity to prevent further respiratory impairment in Japan. We showed that aminophylline, used at recommended doses, aggravated neuronal injury as indicated by increased serum CK-BB activity, a reduction in the number of cells in the hippocampal CA1 region, and increased lipid peroxide levels and a decreased GSH:GSSG ratio in brain tissue under hypoxic conditions induced by low-tidal volume ventilation in guinea pigs. We also showed that these effects were attenuated by treatment with the free radical scavenger, edaravone. The results suggest that aminophylline treatment aggravates the central nervous system of patients with hypoxemia.
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Report
(4 results)
Research Products
(7 results)
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[Presentation] 呼吸促進薬の中枢神経傷害性および神経突起成長に及ぼす影響2008
Author(s)
山口圭太郎, 染川智子, 伊藤禎子, 河内山佳英, 冨安麻友, 石塚洋一, 森内宏志, 入倉充, 副田二三夫, 白崎哲哉, 高濱和夫, 安東由喜雄, 香月博志, 入江徹美
Organizer
第25回日本薬学会九州支部大会
Place of Presentation
延岡市九州保健福祉大学
Related Report
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