| Project/Area Number |
20590542
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Applied pharmacology
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| Research Institution | University of the Ryukyus |
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Principal Investigator |
YAMAKAWA Ken University of the Ryukyus, 大学院・医学研究科, 講師 (00363664)
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| Co-Investigator(Kenkyū-buntansha) |
YASU Takanori 琉球大学, 大学院・医学研究科, 准教授 (40265278)
SHIMABUKURO Michio 徳島大学, 大学院・ヘルスバイオサイエンス研究部, 特任教授 (60271144)
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| Co-Investigator(Renkei-kenkyūsha) |
UEDA Shinichiro 琉球大学, 大学院・医学研究科, 教授 (80285105)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2009: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2008: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Keywords | 臨床薬理学 / 血管内皮機能 / 動脈硬化 / 薬効評価 / インスリン抵抗性 / 代替エンドポイント |
|---|
| Research Abstract |
Vascular endothelial function is not only a predictor of future cardio vascular events, but an useful therapeutic marker. We investigated pharmacometric analysis on vascular endothelial function for several cardiovascular drugs and their therapeutic mechanisms.
We adopted free fatty acids (FFA) loading model of human to investigate vascular and metabolic pathophysiology of visceral fat obesity. Elevated FFA caused endothelial dysfunction, increased sticking strength of leukocytes and insulin resistance partly via leukocyte renin-angiotensin system. Leukocyte renin-angiotensin system activity could be a marker of vascular endothelial dysfunction which accompanies visceral fat obesity.
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