| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2010: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2009: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2008: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Research Abstract |
Thrombopietin is the most important cytokine for thrombopoiesis. The importance of thrombopoietin signaling is immediately apparent; morbidity and mortality from bleeding due to moderate to severe thrombocytopenia is a major problem of a wide range of patients. The aim of this study is to find the molecules that interact with Akt, serine-threonine kinase which plays a crucial role for megakaryocytopoiesis, in human hematopoietic cells. To this end, we established the affinity purification and proteomic analysis to elucidate the role of Akt signaling in megakaryocytopoiesis. However, we could not detect Akt-binding protein under thrombopoietin-dependent manner.
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