Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2010: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2009: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2008: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
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Research Abstract |
Pathophysiological mechanism of Familial Juvenile Hyperuricemic Nephropathy (FJHN) was investigated by production of the FJHN model mice, mutated human uromodulin gene transgenic mice. In the kidneys of the mice, it was observed that androgen action enhanced by increasing of Srd5a2 gene transcription should induce the transcription of Cyp4a12a gene, which causes renal cyst formation and renal damage ("nephropathy"), and that of Slc22a12 gene, which causes hyperuricemia.
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