| Project/Area Number |
20590548
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Applied pharmacology
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| Research Institution | Meiji Pharmaceutical University |
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Principal Investigator |
TAKAHASHI Harumi Meiji Pharmaceutical University, 薬学部, 教授 (20211344)
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| Co-Investigator(Kenkyū-buntansha) |
ECHIZEN Hirotoshi 明治薬科大学, 薬学部, 教授 (00191924)
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| Co-Investigator(Renkei-kenkyūsha) |
GOTO Shinya 東海大学, 医学部, 教授 (50225653)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2010: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2009: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2008: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | ワルファリン / 個体差 / 応答性 / CYP2C9 / VKORC1 / 遺伝子多型 / INR / 抗凝固効果 / 投与前凝固活性 / VKORC1*2 / CYP4F2*3 |
|---|
| Research Abstract |
Influences of CYP2C9^*3 and VKORC1^*2 polymorphisms on the inter-individual differences in anticoagulation responses and maintenance dosages of warfarin were investigated in Asian (Japanese & Chinese) patients by performing the retrospective and prospective clinical studies. As a results, a CYP2C9^*3 mutation and a body weight, and VKORC1^*2 mutation and an age were extracted as pharmacokinetic and pharmacodynamic covariates, respectively.
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