| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2009: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2008: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Research Abstract |
In the present study, we investigated the role intestinal macrophages in the pathogenesis of gastrointestinal diseases.
1. The activation of α7 nicotinic acetylcholine receptor (α7nAChR) suppresses the severity of intestinal lesions induced by non-steroidal anti-inflammatory drugs (NSAID).
2. Dopamine D2 receptor antagonists significantly prevent NSAID-induced intestinal lesions through activation ofα7nAChR.
3. The aggravation of NSAID-induced gastric damage during arthritis is attributable to the upregulation of iNOS and eNOS.
4. Lansoprazole, a proton pump inhibitor, protects NSAID-induced intestinal lesions through induction of heme oxygenase (HO)-1.
5. Macrophages play a beneficial role in the healing of chronic gastric ulcers mediated by increase in neovascularization through upregulation of cyclooxygenase (COX)-2 and vascular endothelial growth factor (VEGF).
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