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Development of inorganic zinc-containing medicines with anti-obesity action

Research Project

Project/Area Number 20590551
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Applied pharmacology
Research InstitutionKyoto Pharmaceutical University

Principal Investigator

YASUI Hiroyuki  Kyoto Pharmaceutical University, 薬学部, 教授 (20278443)

Co-Investigator(Kenkyū-buntansha) YOSHIKAWA Yutaka  京都薬科大学, 薬学部, 講師 (20388028)
Co-Investigator(Renkei-kenkyūsha) HIROMURA Makoto  独立行政法人理化学研究所, 神戸研究所・分子イメージングセンター, 協力研究員 (30411036)
Project Period (FY) 2008 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2009: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2008: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords肥満抑制作用 / メタボリック症候群 / 2型糖尿病 / 亜鉛錯体 / 体内動態 / 膵リパーゼ阻害 / 膵アミラーゼ阻害 / α-グルコシダーゼ阻害
Research Abstract

Several anti-diabetic zinc(II) complexes have been developed on the basis of synthesis of ligands and complexes, evaluation of physico-chemical properties, in vitro assays such as inhibition of free fatty acid from freshly isolated rat adipocytes, enhancement of adiponectine secretion in 3T3-L1 cultured adipocytes, inhibition of alpha-glucosidase from rat small intestine and lipase from porcine pancreas, in vivo animal experiments using type 2 diabetic model KKAy mice. From these studies, zinc-thiotropone complex of which ligand is derived from natural compounds was found to exhibit more hypoglycemic action than usual by oral administration. Then, pharmacokinetic (PK) analysis and organ distribution of this complex were examined by determination of radio-labeled zinc tracer (^<65>Zn) in order to evaluation the target organs, and in addition anti-obesity action was investigated. Zinc-thiotropone complex was distributed to liver and muscle which enhanced the improvement of glucose metabolism; however, this complex was not distributed to adipose tissues and exhibited no action. This disposition property led no anti-obesity action but side-effect of hyperlipemia, which might be caused by insufficient transfer and accumulation of triglyceride produced in liver to adipose tissues. In the future study, we need to molecular-design and develop zinc complexes with distribution and action properties to liver, muscle and adipose on the basis of PK-pharmacodynamic analysis.

Report

(4 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report
  • 2008 Annual Research Report
  • Research Products

    (94 results)

All 2011 2010 2009 2008 Other

All Journal Article (21 results) (of which Peer Reviewed: 21 results) Presentation (57 results) Book (10 results) Remarks (4 results) Patent(Industrial Property Rights) (2 results)

  • [Journal Article] Challenge of studies on the development of new Zn complexes (Zn(opt)_2) to treat diabetes mellitus2011

    • Author(s)
      Yutaka Yoshikawa, Akito Murayama, Yusuke Adachi, Hiromu Sakurai, Hiroyuki Yasui
    • Journal Title

      Metallomics Vol.3(in press)

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Synthesis and in vitro insulin-mimetic activities of zinc(II) complexes of ethyl 2,5-dihydro-4-hydroxy-5-oxo-1H-pyrrole-3-carboxylates2011

    • Author(s)
      Hiraku Kawarada, Yutaka Yoshikawa, Hiroyuki Yasui, Shunsuke Kuwahara, Yoichi Habata, Makoto Tamaki, Ryota Saito
    • Journal Title

      Metallomics Vol.3(in press)

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Zinc complexes developed as metallo- pharmaceutics for treating diabetes mellitus based on the bio-medicinal inorganic chemistry2011

    • Author(s)
      吉川豊, 安井裕之
    • Journal Title

      Curr. Topics Med.Chem Vol.11(in press)

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Cellular mechanism of Zinc-hinokitiol complexes in diabetes mellitus2011

    • Author(s)
      Yuki Naito, Yutaka Yoshikawa, Hiroyuki Yasui
    • Journal Title

      Bull Chem.Soc.Jpn Vol.84

      Pages: 298-305

    • NAID

      10028046282

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Cellular mechanism of Zinc-hinokitiol complexes in diabetes mellitus.2011

    • Author(s)
      Yuki Naito, Yutaka Yoshikawa, Hiroyuki Yasui
    • Journal Title

      Bull Chem.Soc.Jpn.

      Volume: 84 Pages: 298-305

    • NAID

      10028046282

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Zinc complexes developed as metallopharmaceutics for treating diabetes mellitus based on the bio-medicinal inorganic chemistry.2011

    • Author(s)
      Yutaka Yoshikawa, Hiroyuki Yasui
    • Journal Title

      Curr.Topics Med.Chem.

      Volume: 11(in press)

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Synthesis and in vitro insulin-mimetic activities of zinc(II) complexes of ethyl 2,5-dihydro-4-hydroxy-5-oxo-1H-pyrrole-3-carboxylates.2011

    • Author(s)
      Hiraku Kawarada, Yutaka Yoshikawa, Hiroyuki Yasui
    • Journal Title

      Metallomics

      Volume: 3(in press)

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Challenge of studies on the development of new Zn complexes (Zn(opt)2) to treat diabetes mellitus.2011

    • Author(s)
      Yutaka Yoshikawa, Hiroyuki Yasui
    • Journal Title

      Metallomics

      Volume: 3(in press)

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Inhibitory effect of CuSO4 on alpha-glucosidase activity in ddY mice2010

    • Author(s)
      Yutaka Yoshikawa, Ryoko Hirata, Hiroyuki Yasui, Masakazu Hattori, Hiromu Sakurai
    • Journal Title

      Metallomics Vol.2

      Pages: 67-73

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Inhibitory effect of CuSO4 on a-glucosidase activity in ddY mice.2010

    • Author(s)
      Yutaka Yoshikawa, Hiroyuki Yasui
    • Journal Title

      Metallomics

      Volume: 2 Pages: 67-73

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Synthesis of metal complexes with 1-substituted 3-hydroxy-2(1H)-pyridinethiones and their insulin-mimetic activities.2010

    • Author(s)
      Akira Katoh, Yutaka Yoshikawa, Hiroyuki Yasui
    • Journal Title

      Heterocycles

      Volume: 81 Pages: 585-600

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Inhibitory effect of CuSO_4 on α-glucosidase activity in ddY mice.2010

    • Author(s)
      Yutaka Yoshikawa, Ryoko Hirata, Hiroyuki Yasui, Masakazu Hattori, Hiromu Sakurai
    • Journal Title

      Metallomics 2

      Pages: 67-73

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Synthesis of metal complexes with 1-substituted 3-hydroxy-2(1H)-pyridinethiones and their insulin-mimetic activities.2010

    • Author(s)
      Akira Katoh, Hiroko Yokoyama, Yuriko Matsumura, Yutaka Yoshikawa, Hiroyuki Yasui, Hiromu Sakurai
    • Journal Title

      Heterocycles 81

      Pages: 585-600

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Alpha-glucosidase inhibitory effect of anti-diabetic metal ions and their complexes2009

    • Author(s)
      Yutaka Yoshikawa, Ryoko Hirata, Hiroyuki Yasui, Hiromu Sakurai
    • Journal Title

      Biochimie Vol.91

      Pages: 1339-1341

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Evaluation of insulin-mimetic activities of vanadyl and zinc(II)complexes from the viewpoint of heterocyclic bidentate ligands.2009

    • Author(s)
      Akira Katoh, Yuriko Matsumura, Yutaka Yoshikawa, Hiroyuki Yasui, Hiromu Sakurai
    • Journal Title

      J.Inorg.Biochem. 103

      Pages: 567-574

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Alpha-glucosidase inhibitory effect of anti-diabetic metal ions and their complexes.2009

    • Author(s)
      Yutaka Yoshikawa, Ryoko Hirata, Hiroyuki Yasui, Hiromu Sakurai
    • Journal Title

      Biochimie 91

      Pages: 1339-1341

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Current state for the development of metallopharmaceutics and anti-diabetic metal complexes2008

    • Author(s)
      桜井弘, 吉川豊, 安井裕之
    • Journal Title

      Chemical Society Review Vol.37

      Pages: 2383-2392

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] グルコン酸亜鉛及びグルコン酸胴を用いた保険機能食品の開発-テキーラの原料植物アガベから取った水溶性食物繊維(アガベ・イヌリン)の効果-2008

    • Author(s)
      小嶋良種、小倉哲也、吉川豊、市村彰男、安井裕之、桜井弘
    • Journal Title

      グルコン酸の研究 1巻

      Pages: 2-15

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Photocontrol of spatial orientation and DNA cleavage activity of copper(II)-bound dipeptides linked by an azobenzene derivative.2008

    • Author(s)
      Halan Prakash, Akemi Shodai, Hiroyuki Yasui, Hiromu Sakurai, Shun Hirota
    • Journal Title

      Inorganic Chemistry 47

      Pages: 5045-5047

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] グルコン酸亜鉛及びグルコン酸胴を用いた保険機能食品の開発-テキーラの原料植物アガベから取った水溶性食物繊維(アガペーイヌリン)の効果-2008

    • Author(s)
      小嶋良種, 小倉哲也, 吉川豊, 市村彰男, 安井裕之, 桜井弘
    • Journal Title

      グルコン酸の研究 1

      Pages: 2-15

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Current state for the development of metallopharmaceutics and anti-diabetic metal complexes2008

    • Author(s)
      Hiromu Sakurai, Yutaka Yoshikawa, Hiroyuki Yasui
    • Journal Title

      Chemical Society Review 37

      Pages: 2383-2392

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Presentation] 抗糖尿病作用を有する新規亜鉛錯体の開発研究-HSAB則に基づいた構造活性相関-2011

    • Author(s)
      藤本重行、吉川豊、安井裕之
    • Organizer
      日本薬学会第131年会
    • Place of Presentation
      静岡
    • Year and Date
      2011-03-30
    • Related Report
      2010 Annual Research Report 2010 Final Research Report
  • [Presentation] 高脂肪食が糖代謝および微量元素の体内分布に及ぼす影響2011

    • Author(s)
      竹田万里子、吉川豊、安井裕之
    • Organizer
      日本薬学会第131年会
    • Place of Presentation
      静岡
    • Year and Date
      2011-03-30
    • Related Report
      2010 Annual Research Report 2010 Final Research Report
  • [Presentation] 亜鉛および銅含有二核錯体の抗糖尿病活性2011

    • Author(s)
      名波谷紀子、吉川豊、安井裕之
    • Organizer
      日本薬学会第131年会
    • Place of Presentation
      静岡
    • Year and Date
      2011-03-30
    • Related Report
      2010 Annual Research Report
  • [Presentation] Action mechanism of insulinomimetic Zn complexes in insulin signaling pathway f 3T3-L1 adiposytes2010

    • Author(s)
      Yuki Naito, Yutaka Yoshikawa, Hiroyuki Yasui
    • Organizer
      Pacifichem2010
    • Place of Presentation
      Honolulu, Hawaii
    • Year and Date
      2010-12-16
    • Related Report
      2010 Annual Research Report
  • [Presentation] Action mechanism of insulinomimetic Zn complexes in insulin signaling pathway of 3T3-L1 adipocytes2010

    • Author(s)
      Yuki Naito, Yutaka Yoshikawa, Hiroyuki Yasui
    • Organizer
      Pacifichem2010
    • Place of Presentation
      Honolulu, Hawaii
    • Year and Date
      2010-12-15
    • Related Report
      2010 Final Research Report
  • [Presentation] alpha-Glucosidase and ACE inhibitory effects of Zn and various first transition metals2010

    • Author(s)
      Yutaka Yoshikawa, Naoko Seta, Ryoko Hirata, Hiromu Sakurai, Hiroyuki Yasui
    • Organizer
      Pacifichem2010
    • Place of Presentation
      Honolulu, Hawaii
    • Year and Date
      2010-12-15
    • Related Report
      2010 Final Research Report
  • [Presentation] a-Glucosidase and ACE inhibitory effects of Zn and various first transition metals2010

    • Author(s)
      Yutaka Yoshikawa, Hiroyuki Yasui
    • Organizer
      Pacifichem2010
    • Place of Presentation
      Honolulu, Hawaii
    • Year and Date
      2010-12-15
    • Related Report
      2010 Annual Research Report
  • [Presentation] 2-メルカプトピリジン-N-オキシドを配位子にもつ金属錯体の抗糖尿病作用2010

    • Author(s)
      吉川豊、村山彰人、安達祐介、桜井弘、安井裕之
    • Organizer
      第2回メタロミクス研究フォーラム
    • Place of Presentation
      京都
    • Year and Date
      2010-11-03
    • Related Report
      2010 Annual Research Report 2010 Final Research Report
  • [Presentation] 血糖降下作用を有する亜鉛錯体の体内動態解析2010

    • Author(s)
      邑上裕紀、吉川豊、安井裕之
    • Organizer
      第2回メタロミクス研究フォーラム
    • Place of Presentation
      京都
    • Year and Date
      2010-11-03
    • Related Report
      2010 Annual Research Report 2010 Final Research Report
  • [Presentation] 糖尿病合併症治療薬候補化合物を配位子とした亜鉛錯体の合成とインスリン様活性評価2010

    • Author(s)
      齋藤良太、河原田光、吉川豊、安井裕之
    • Organizer
      第2回メタロミクス研究フォーラム
    • Place of Presentation
      京都
    • Year and Date
      2010-11-03
    • Related Report
      2010 Annual Research Report 2010 Final Research Report
  • [Presentation] 天然ポリウロン酸類を用いた亜鉛複合体の合成と薬理活性2010

    • Author(s)
      舘祥光、前岡嘉晃、吉川豊、安井裕之、森本善樹
    • Organizer
      第2回メタロミクス研究フォーラム
    • Place of Presentation
      京都
    • Year and Date
      2010-11-03
    • Related Report
      2010 Annual Research Report 2010 Final Research Report
  • [Presentation] アミノ酸亜鉛錯体の糖尿病病態改善効果に関する研究2010

    • Author(s)
      藤井嵩子, 吉川豊, 安井裕之
    • Organizer
      第2回メタロミクス研究フォーラム
    • Place of Presentation
      京都
    • Year and Date
      2010-11-03
    • Related Report
      2010 Annual Research Report
  • [Presentation] 新規亜鉛高含有食品としてのパパイア粉末/亜鉛(II)錯体の抗糖尿病効果2010

    • Author(s)
      世良享子, 吉川豊, 安井裕之
    • Organizer
      第2回メタロミクス研究フォーラム
    • Place of Presentation
      京都
    • Year and Date
      2010-11-03
    • Related Report
      2010 Annual Research Report
  • [Presentation] ビタミン類の亜鉛錯体の抗メタボリックシンドローム作用に関する研究2010

    • Author(s)
      松本衣代, 吉川豊, 安井裕之
    • Organizer
      第2回メタロミクス研究フォーラム
    • Place of Presentation
      京都
    • Year and Date
      2010-11-03
    • Related Report
      2010 Annual Research Report
  • [Presentation] 抗糖尿病作用を有する亜鉛錯体のラット赤血球移行性2010

    • Author(s)
      本田哲郎、傅寶和佳子、安井裕之、吉川豊
    • Organizer
      第21回日本微量元素学会
    • Place of Presentation
      京都
    • Year and Date
      2010-07-06
    • Related Report
      2010 Annual Research Report 2010 Final Research Report
  • [Presentation] ラット脂肪細胞を用いた各種アミノ酸の亜鉛錯体のインスリン様作用2010

    • Author(s)
      藤井嵩子, 吉川豊, 安井裕之
    • Organizer
      第64回日本栄養・食糧学会大会
    • Place of Presentation
      徳島
    • Year and Date
      2010-05-12
    • Related Report
      2010 Annual Research Report
  • [Presentation] 3T3-L1脂肪細胞のインスリンシグナル経路におけるインスリン様亜鉛錯体の作用機序2010

    • Author(s)
      内藤行喜、吉川豊、安井裕之
    • Organizer
      日本薬学会第130年会
    • Place of Presentation
      岡山
    • Year and Date
      2010-03-30
    • Related Report
      2010 Final Research Report 2009 Annual Research Report
  • [Presentation] 高い抗糖尿病作用を有する亜鉛錯体の作用メカニズム解明へのアプローチ2010

    • Author(s)
      邑上裕紀、吉川豊、夏目優太郎、安井裕之
    • Organizer
      日本薬学会第130年会
    • Place of Presentation
      岡山
    • Year and Date
      2010-03-30
    • Related Report
      2010 Final Research Report 2009 Annual Research Report
  • [Presentation] 糖尿病克服を目指した新規亜鉛錯体の開発研究に挑む2010

    • Author(s)
      吉川豊、桜井弘、安井裕之
    • Organizer
      日本薬学会第130年会一般シンポジウム
    • Place of Presentation
      岡山
    • Year and Date
      2010-03-30
    • Related Report
      2010 Final Research Report 2009 Annual Research Report
  • [Presentation] 第一遷移系列金属の生命錯体化学を基盤としたファーマコメタロミクス研究2010

    • Author(s)
      安井裕之
    • Organizer
      日本薬学会第130年会一般シンポジウム
    • Place of Presentation
      岡山(招待講演)
    • Year and Date
      2010-03-30
    • Related Report
      2010 Final Research Report
  • [Presentation] 第一遷移系列金属の生命錯体化学を基盤としたファーマコメタロミクス研究2010

    • Author(s)
      安井裕之(招待講演)
    • Organizer
      日本薬学会第130年会一般シンポジウム
    • Place of Presentation
      岡山
    • Year and Date
      2010-03-30
    • Related Report
      2009 Annual Research Report
  • [Presentation] ウロン酸及びその類縁体を配位しとする亜鉛錯体の合成2010

    • Author(s)
      前岡嘉晃、吉川豊、安井裕之、森本善樹、舘祥光
    • Organizer
      日本化学会第90春季年会
    • Place of Presentation
      大阪
    • Year and Date
      2010-03-26
    • Related Report
      2010 Final Research Report 2009 Annual Research Report
  • [Presentation] 1-置換 2-アリール-3-ヒドロキシ-4(1H)-キノリンチオン類-亜鉛錯体の合成とインスリン様活性2010

    • Author(s)
      加藤明良, 原島博史, 松村有里子, 吉川豊, 安井裕之, 桜井弘
    • Organizer
      日本化学会第90春季年会
    • Place of Presentation
      大阪
    • Year and Date
      2010-03-26
    • Related Report
      2009 Annual Research Report
  • [Presentation] 3-ヒドロキシフラボン誘導体-金属錯体の合成とそれらのインスリン様活性評価2010

    • Author(s)
      加藤明良, 今川翔太, 松村有里子, 吉川豊, 安井裕之, 桜井弘
    • Organizer
      日本化学会第90春季年会
    • Place of Presentation
      大阪
    • Year and Date
      2010-03-26
    • Related Report
      2009 Annual Research Report
  • [Presentation] トロポロン誘導体-亜鉛錯体の合成とそれらのメタボリックシンドローム改善薬への応用2010

    • Author(s)
      加藤明良, 加藤博孝, 松村有里子, 吉川豊, 安井裕之, 桜井弘, 青木伸
    • Organizer
      日本化学会第90春季年会
    • Place of Presentation
      大阪
    • Year and Date
      2010-03-26
    • Related Report
      2009 Annual Research Report
  • [Presentation] 糖尿病及びメタボリックシンドローム治療のための5-ヒドロキシ-4(1H)-ピリジンチオン類-バナジル及び亜鉛錯体の合成2010

    • Author(s)
      加藤明良, 光石亮太, 松村有里子, 吉川豊, 安井裕之, 桜井弘
    • Organizer
      日本化学会第90春季年会
    • Place of Presentation
      大阪
    • Year and Date
      2010-03-26
    • Related Report
      2009 Annual Research Report
  • [Presentation] 亜鉛トロポノイド錯体の抗糖尿病作用-硫黄原子導入による構造活性相関-2009

    • Author(s)
      邑上裕紀、松尾岳志、吉川豊、安井裕之
    • Organizer
      第28回メディシナルケミストリーシンポジウム
    • Place of Presentation
      東京
    • Year and Date
      2009-11-25
    • Related Report
      2010 Final Research Report 2009 Annual Research Report
  • [Presentation] 複数の物理化学的特性にもとづいた亜鉛錯体のラット赤血球移行性2009

    • Author(s)
      傅寶和佳子、吉川豊、安井裕之
    • Organizer
      第59回日本薬学会近畿支部総会・大会
    • Place of Presentation
      大阪
    • Year and Date
      2009-10-25
    • Related Report
      2010 Final Research Report 2009 Annual Research Report
  • [Presentation] 微量金属と糖尿病-特にメタボリックシンドローム-2009

    • Author(s)
      安井裕之(招待講演)
    • Organizer
      第11回神戸「食と健康」研究会
    • Place of Presentation
      神戸(神戸女子大学)
    • Year and Date
      2009-10-17
    • Related Report
      2010 Final Research Report 2009 Annual Research Report
  • [Presentation] 天然多糖類の構成成分ウロン酸を配位子に用いた亜鉛錯体の構造と機能2009

    • Author(s)
      前岡嘉晃、吉川豊、安井裕之、森本善樹、舘祥光
    • Organizer
      第59回錯体化学討論会
    • Place of Presentation
      長崎
    • Year and Date
      2009-09-25
    • Related Report
      2010 Final Research Report 2009 Annual Research Report
  • [Presentation] 私たちの健康と生体微量元素2009

    • Author(s)
      安井裕之
    • Organizer
      立命館大学土曜講座
    • Place of Presentation
      京都(立命館大学)(招待講演)
    • Year and Date
      2009-09-12
    • Related Report
      2010 Final Research Report
  • [Presentation] 私たちの健康と生体微量元素2009

    • Author(s)
      安井裕之(招待講演)
    • Organizer
      立命館大学土曜講座
    • Place of Presentation
      京都(立命館大学)
    • Year and Date
      2009-09-12
    • Related Report
      2009 Annual Research Report
  • [Presentation] Synthesis and Insulin-Mimetic activities of zinc(II) complexes with ethyl 2,5-dihydro-4-hydroxy-5-oxo-1H-pyrrole-3-carboxylates2009

    • Author(s)
      Ryota Saito, Hikaru Kawarada, Yutaka Yoshikawa, Hiroyuki Yasui
    • Organizer
      14th International Conference on Biological Inorganic Chemistry
    • Place of Presentation
      名古屋
    • Year and Date
      2009-07-25
    • Related Report
      2010 Final Research Report
  • [Presentation] Synthesis and Insulin-Mimetic activities of zinc(II)complexes with ethyl 2,5-dihydro-4-hydroxy-5-oxo-1H-pyrrole-3-carboxylates2009

    • Author(s)
      Ryota Saito, Hikaru Kawarada, Yutaka Yoshikawa, Hiroyuki Yasui
    • Organizer
      14th International Conference on Biological Inorganic Chemistry
    • Place of Presentation
      名古屋
    • Year and Date
      2009-07-25
    • Related Report
      2009 Annual Research Report
  • [Presentation] 臓器観測用インビボESR法と統合理論によるMechanism-based PK-PD解析2009

    • Author(s)
      安井裕之
    • Organizer
      岡山シンポジウム「最先端計測技術のトレンド2009」
    • Place of Presentation
      岡山(岡山大学・薬学部)(招待講演)
    • Year and Date
      2009-06-29
    • Related Report
      2010 Final Research Report
  • [Presentation] 臓器観測用インビボESR法と統合理論によるMechanism-based PK-PD解析2009

    • Author(s)
      安井裕之(招待講演)
    • Organizer
      岡山シンポジウム「最先端計測技術のトレンド2009」
    • Place of Presentation
      岡山(岡山大学・薬学部)
    • Year and Date
      2009-06-29
    • Related Report
      2009 Annual Research Report
  • [Presentation] Synthesis of zinc(II)complexes with benzo-fused hydroxyazines and their insulin-mimetic activities2009

    • Author(s)
      Akira Katoh, Naoko Yagisawa, Maki Asaga, Yuriko Matsumura, Yutaka Yoshikawa, Hiroyuki Yasui, Hiromu Sakurai
    • Organizer
      Second International Symposium on Metallomics
    • Place of Presentation
      Cincinnati
    • Year and Date
      2009-06-12
    • Related Report
      2009 Annual Research Report
  • [Presentation] トロポロン誘導体-亜鉛錯体の合成とそれらのメタボリックシンドローム改善薬への応用2009

    • Author(s)
      加藤明良, 加藤博孝, 松村有里子, 吉川豊, 安井裕之, 桜井弘
    • Organizer
      第57回有機合成化学協会関東支部シンポジウム
    • Place of Presentation
      東京
    • Year and Date
      2009-05-25
    • Related Report
      2009 Annual Research Report
  • [Presentation] 2型糖尿病モデルマウス(KK-Ay)における亜鉛錯体の病態改善効果2009

    • Author(s)
      世良享子, 松本衣代, 本保奈緒, 藤井嵩子, 吉川豊, 安井裕之, 谷口洋, 小嶋良種, 梶原苗美
    • Organizer
      第63回日本栄養・食糧学会大会
    • Place of Presentation
      長崎
    • Year and Date
      2009-05-15
    • Related Report
      2009 Annual Research Report
  • [Presentation] 抗糖尿病・抗酸化作用を有する高活性第一遷移系列金属錯体の探索2009

    • Author(s)
      吉川豊、村山彰人、安達祐介、桜井弘、安井裕之
    • Organizer
      第129回日本薬学会年会
    • Place of Presentation
      京都
    • Year and Date
      2009-03-28
    • Related Report
      2010 Final Research Report
  • [Presentation] 抗糖尿病・抗酸化作用を有する高活性第一遷移系列金属錯体の探索.2009

    • Author(s)
      吉川豊, 村山彰人, 安達祐介, 桜井弘, 安井裕之
    • Organizer
      第129回日本薬学会年会
    • Place of Presentation
      京都
    • Year and Date
      2009-03-28
    • Related Report
      2008 Annual Research Report
  • [Presentation] 必須微量金属亜鉛の体内動態と吸収.2009

    • Author(s)
      山本貴紀, 長野こずえ, 吉川豊, 安井裕之, 勝見英正, 坂根稔康, 山本昌
    • Organizer
      第129回日本薬学会年会
    • Place of Presentation
      京都
    • Year and Date
      2009-03-27
    • Related Report
      2008 Annual Research Report
  • [Presentation] ウロン酸を配位子に用いた亜鉛錯体の合成2009

    • Author(s)
      前岡嘉晃、吉川豊、安井裕之、舘祥光
    • Organizer
      日本化学会第89春季年会
    • Place of Presentation
      東京
    • Year and Date
      2009-03-25
    • Related Report
      2010 Final Research Report
  • [Presentation] ウロン酸を配位子に用いた亜鉛錯体の合成.2009

    • Author(s)
      前岡嘉晃, 吉川豊, 安井裕之, 舘祥光
    • Organizer
      日本化学会第89春季年会
    • Place of Presentation
      東京
    • Year and Date
      2009-03-25
    • Related Report
      2008 Annual Research Report
  • [Presentation] 第一遷移系列金属イオン及び金属錯体を用いた膵リパーゼの阻害効果2008

    • Author(s)
      吉川豊、栗山芳樹、金岡千明、安井裕之
    • Organizer
      第一回メタロミクス研究フォーラム
    • Place of Presentation
      東京
    • Year and Date
      2008-11-28
    • Related Report
      2010 Final Research Report
  • [Presentation] 第一遷移系列金属イオン及び金属錯体を用いた膵りパーゼの阻害効果.2008

    • Author(s)
      吉川豊, 栗山芳樹, 金岡千明, 安井裕之
    • Organizer
      第一回メタロミクス研究フォーラム
    • Place of Presentation
      東京
    • Year and Date
      2008-11-28
    • Related Report
      2008 Annual Research Report
  • [Presentation] 第一遷移系列金属イオン及び金属錯体による脂質過酸化反応の抑制効果.2008

    • Author(s)
      安井裕之, 寺嶋典子, 中尾好絵, 吉川豊
    • Organizer
      第一回メタロミクス研究フォーラム
    • Place of Presentation
      東京
    • Year and Date
      2008-11-28
    • Related Report
      2008 Annual Research Report
  • [Presentation] α-グルコシダーゼ阻害作用を有する各種金属および金属錯体2008

    • Author(s)
      吉川豊、平田良子、安井裕之、桜井弘
    • Organizer
      第27回メディシナルケミストリーシンポジウム
    • Place of Presentation
      大阪
    • Year and Date
      2008-11-27
    • Related Report
      2010 Final Research Report
  • [Presentation] α-グルコシダーゼ阻害作用を有する各種金属および金属錯体.2008

    • Author(s)
      吉川豊, 平田良子, 安井裕之, 桜井弘
    • Organizer
      第27回メディシナルケミストリーシンポジウム
    • Place of Presentation
      大阪
    • Year and Date
      2008-11-27
    • Related Report
      2008 Annual Research Report
  • [Presentation] Absorption and disposition of zinc in healthy rat after oral administration.2008

    • Author(s)
      Kozue Nagano, Takanori Yamamoto, Yutaka Yoshikawa, Hiroyuki Yasui, Hidemasa Katsumi, Toshiyasu Sakane, Akira Yamamoto
    • Organizer
      日本薬物動態学会 第23回年会
    • Place of Presentation
      熊本
    • Year and Date
      2008-10-31
    • Related Report
      2008 Annual Research Report
  • [Presentation] 経口投与可能なバナジウム-および亜鉛-ステアリン酸錯体の抗糖尿病作用2008

    • Author(s)
      吉川豊、安達祐介、安井裕之、桜井弘
    • Organizer
      第58回日本薬学会近畿支部総会・大会
    • Place of Presentation
      神戸
    • Year and Date
      2008-10-25
    • Related Report
      2010 Final Research Report
  • [Presentation] 経口投与可能なバナジウム-および亜鉛-ステアリン酸錯体の抗糖尿病作用.2008

    • Author(s)
      吉川豊, 安達祐介, 安井裕之, 桜井弘
    • Organizer
      第58回日本薬学会近畿支部総会・大会
    • Place of Presentation
      神戸
    • Year and Date
      2008-10-25
    • Related Report
      2008 Annual Research Report
  • [Presentation] 1-アリール置換3-ヒドロキシー4(1H)-ピリジンチオン類の金属錯体の合成とそれらのインスリン様活性評価.2008

    • Author(s)
      加藤明良, 松村有里子, 八木沢尚子, 吉川豊, 安井裕之, 桜井弘
    • Organizer
      第58回錯体化学討論会
    • Place of Presentation
      金沢
    • Year and Date
      2008-09-25
    • Related Report
      2008 Annual Research Report
  • [Presentation] α-Glucosidase inhibitory effect of first transition metals2008

    • Author(s)
      Yutaka Yoshikawa, Ryoko Hirata, Hiroyuki Yasui, Hiromu Sakurai
    • Organizer
      The fourth international conference on metals and genetics
    • Place of Presentation
      Paris
    • Year and Date
      2008-07-23
    • Related Report
      2010 Final Research Report
  • [Presentation] α-Glucosi dase inhibitory effect of first transition metals.2008

    • Author(s)
      Yutaka Yoshikawa, Ryoko Hirata, Hiroyuki Yasui, Hiromu Sakurai
    • Organizer
      The fourth international conference on metals and genetics
    • Place of Presentation
      Paris
    • Year and Date
      2008-07-23
    • Related Report
      2008 Annual Research Report
  • [Presentation] Orally active anti-diabetic Zn (II) complexes with 2-mercaptopyridine N-oxide2008

    • Author(s)
      吉川豊, 村山彰人, 安達祐介, 安井裕之, 桜井弘
    • Organizer
      第18回金属の関与する生体関連反応シンポジウム
    • Place of Presentation
      名古屋
    • Year and Date
      2008-06-05
    • Related Report
      2010 Final Research Report
  • [Presentation] Orally active anti-diabetic Zn (II) complexes with 2-mercaptopyridine N-oxide.2008

    • Author(s)
      Yutaka Yoshikawa, Akito Murayama, Yusuke Adachi, Hiroyuki Yasui, Hiromu Sakurai
    • Organizer
      第18回金属の関与する生体関連反応シンポジウム
    • Place of Presentation
      名古屋
    • Year and Date
      2008-06-05
    • Related Report
      2008 Annual Research Report
  • [Book] 分析化学プラクティス第2版2011

    • Author(s)
      安井裕之、吉川豊
    • Total Pages
      197
    • Publisher
      京都廣川書店
    • Related Report
      2010 Final Research Report
  • [Book] 分析化学プラクティス 第2版2011

    • Author(s)
      安井裕之、吉川豊
    • Total Pages
      197
    • Publisher
      京都廣川書店
    • Related Report
      2010 Annual Research Report
  • [Book] 生命錯体無機化学のサブノート2010

    • Author(s)
      廣田俊、安井裕之
    • Total Pages
      178
    • Publisher
      京都廣川書店
    • Related Report
      2010 Annual Research Report 2010 Final Research Report
  • [Book] 臨床分析学のサブノート2010

    • Author(s)
      安井裕之、吉川豊
    • Total Pages
      152
    • Publisher
      京都廣川書店
    • Related Report
      2010 Annual Research Report 2010 Final Research Report
  • [Book] 薬学分析科学の最前線(分担執筆 p.16-17)2009

    • Author(s)
      安井裕之、吉川豊
    • Total Pages
      185
    • Publisher
      じほう
    • Related Report
      2010 Final Research Report
  • [Book] 分析化学プラクティス-解説と演習により深まる理解-2009

    • Author(s)
      安井裕之、吉川豊
    • Total Pages
      191
    • Publisher
      京都廣川書店
    • Related Report
      2010 Final Research Report
  • [Book] 分析化学プラクティス-解説と演習により深まる理解-2009

    • Author(s)
      安井裕之, 吉川豊
    • Total Pages
      191
    • Publisher
      京都廣川書店
    • Related Report
      2009 Annual Research Report
  • [Book] 薬学分析科学の最前線(分担執筆p.16-17)2009

    • Author(s)
      安井裕之, 吉川豊
    • Total Pages
      185
    • Publisher
      じほう
    • Related Report
      2009 Annual Research Report
  • [Book] 生命錯体化学のサブノート-生命元素の化学・生物学を医薬品開発に活かす-2008

    • Author(s)
      廣田俊、安井裕之
    • Total Pages
      136
    • Publisher
      京都廣川書店
    • Related Report
      2010 Final Research Report
  • [Book] 生命錯体化学のサブノート-生命元素の化学・生物学を医薬品開発に活かす-2008

    • Author(s)
      廣田俊, 安井裕之
    • Total Pages
      136
    • Publisher
      京都廣川書店
    • Related Report
      2008 Annual Research Report
  • [Remarks] ホームページ等

    • URL

      http://www.kyoto-phu.ac.jp/labo/taisya/index.thml

    • Related Report
      2010 Final Research Report
  • [Remarks]

    • URL

      http://www.kyoto-phu.ac.jp/labo/taisya/index.html

    • Related Report
      2010 Annual Research Report
  • [Remarks]

    • URL

      http://www.kyoto-phu.ac.jp/labo/taisya/index.html

    • Related Report
      2009 Annual Research Report
  • [Remarks]

    • URL

      http://www.kyoto-phu.ac.jp/labo/taisya/index.html

    • Related Report
      2008 Annual Research Report
  • [Patent(Industrial Property Rights)] ミネラル吸収促進食品、ミネラル吸収食品及びミネラル吸収促進方法2009

    • Inventor(s)
      小嶋良種、小倉哲也、吉川豊、安井裕之
    • Industrial Property Rights Holder
      株式会社アガベ
    • Filing Date
      2009-03-24
    • Related Report
      2010 Final Research Report
  • [Patent(Industrial Property Rights)] ミネラル吸収促進食品、ミネラル吸収食品及びミネラル吸収促進方法2009

    • Inventor(s)
      小嶋良種、小倉哲也、吉川豊、安井裕之
    • Industrial Property Rights Holder
      株式会社アガベ
    • Patent Publication Number
      2009-254359
    • Filing Date
      2009-03-24
    • Related Report
      2009 Annual Research Report

URL: 

Published: 2008-04-01   Modified: 2016-04-21  

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