| Project/Area Number |
20590552
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Applied pharmacology
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| Research Institution | Fukuoka University |
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Principal Investigator |
MISHIMA Kenichi Fukuoka University, 薬学部, 准教授 (00320309)
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| Co-Investigator(Kenkyū-buntansha) |
FUJIWARA Michihiro 福岡大学, 薬学部, 教授 (10091331)
IWASAKI Katsunori 福岡大学, 薬学部, 教授 (10183196)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2010: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2009: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2008: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
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| Keywords | 新生児 / 低酸素性虚血性脳症 / 緩徐進行性脳損傷 / 機能再生 / 性差 / 脳虚血 / 学習・記憶 / 再生 / 卵膜由来間葉系幹細胞 / 細胞治療 |
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| Research Abstract |
We recently reported that rehabilitative training tasks during adolescence improve spatial learning impairment following neonatal hypoxic-ischemic (HI) injury in rats without histological improvement. In the present study we focused on sex differences. Wister rat pups were exposed to a unilateral hypoxic-ischemic insult at 7 days of age. Six weeks after hypoxia-ischemia, rehabilitative training tasks were started. The tasks consisted of the plus maze, the eight-arm radial maze, and the choice reaction time task. Sixteen weeks after the HI insult, the water maze task was performed to evaluate spatial learning ability. Afterwards, we morphologically examined brain injury. Our rehabilitative training significantly improved swimming time and length in females but not in males. Likewise, the training ameliorated infarct areas in the injured cerebral hemisphere in females but not in males. These results suggest that it may be important to develop and evaluate cognitive rehabilitation programs for children with brain injury on the basis of gender.
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