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The relationship between biological responses to nitroglycerin and genotypes of the activating enzyme in human, and the application to personalized medicine

Research Project

Project/Area Number 20590553
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Applied pharmacology
Research InstitutionDepartment of Clinical Research, National Hospital Organization Hakodate National Hospital

Principal Investigator

YONEZAWA Kazuya  Department of Clinical Research, National Hospital Organization Hakodate National Hospital, 臨床研究部, 部長 (20301955)

Co-Investigator(Kenkyū-buntansha) MIURA Takeshi  大阪大谷大学, 薬学部, 助教 (60434809)
Project Period (FY) 2008 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2009: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2008: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Keywordsアセトアルデヒド脱水素酵素2(ALDH2) / ニトログリセリン / ファーマコゲノミックス / アセトアルデヒド脱水素酵素
Research Abstract

(No Summary)

Report

(4 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report
  • 2008 Annual Research Report

Research Products

(27 results)

All 2011 2010 2009 2008 2007 2006

All Journal Article (13 results) (of which Peer Reviewed: 11 results) Presentation (10 results) Book (4 results)

  • [Journal Article] Tomoyuki Terada Regulation of Aldo-keto reductase AKR1B10 gene expression : involvement of transcription factor Nrf2.2011

    • Author(s)
      Toru Nishinaka, Takeshi Miura, Manami Okumura, Fumika Nakao, Haruka Nakamura
    • Journal Title

      Chemico-Biological Interactions 191(1-3)

      Pages: 185-191

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Site-directed mutagenesis of ratthioltransferase : effects of essential cysteine residues for the protection against oxidative stress.2010

    • Author(s)
      Tomoyuki Terada、K Okamoto, Junichi Nishikawa, Takeshi Miura, Toru Nishinaka, T Nishihara
    • Journal Title

      Jounal of Biochemistry and Molecular Toxicogy 24(1)

      Pages: 60-65

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Importance of the substrate-biding loop region of human monomeric carbonyl reductases in catalysis and coenzyme binding.2009

    • Author(s)
      Miura Takeshi, Nishinaka T, Terada T
    • Journal Title

      Life Sciences 85(7-8)

      Pages: 303-308

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Investigation of the role of the amino acid residue at position 230 for catalysis in monomeric carbonyl reductase 3.2009

    • Author(s)
      Takeshi Miura, Yuma Itch, Masahi to Takada, Hidenobu Tsutsui, TokihitoYukimura, Torn Nishinaka, Tomoyuki Terada
    • Journal Title

      Chemico-Biological Interactions 178(1-3)

      Pages: 211-214

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Chinese hamster monomeric carbonyl reductases of the short-chain dehydrogenase/reductase superfamily2009

    • Author(s)
      Takeshi Miura, Toru Nishinaka, Masashi Takama, Masahiro Murakami, Tomoyuki Terada
    • Journal Title

      Chemico-Biological Interactions 178(1-3)

      Pages: 110-116

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Relationship between aging and dosage of warfarin : the current status of warfarin anticoagulant therapy for Japanese outpatients in a department of cardiovascular medicine2009

    • Author(s)
      Takeshi Miura, Toru Nishinaka, Tomoyuki Terada, Kazuya Yonezawa
    • Journal Title

      Journal of Cardiology 53(3)

      Pages: 355-360

    • NAID

      10025183714

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Relationship between aging ad dosage of warfarin : the current status of warfarin anticoagulant therapy for Japanese outpatients in a department of cardiovascular medicine2009

    • Author(s)
      Takeshi Miura, Toru Nishinaka, Tomoyuki Terada, Kazuya Yonezawa
    • Journal Title

      Jounal of Cardiology 53

      Pages: 355-360

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Importance of the substrate-binding loop region of human monomeric carbonyl reductases in catalysis and coenzyme binding2009

    • Author(s)
      Takeshi Miura, Toru Nishinaka, Tomoyuki Terada
    • Journal Title

      Life Sciences 85(7-8)

      Pages: 303-308

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Chinese hamster monomeric carbonyl reductases of the short-chain dehydrogenase/reductase superfamily2009

    • Author(s)
      Takeshi Miura, Toru Nishinaka, Masashi Takama, Masahiro Murakami, Tomoyuki Terada
    • Journal Title

      Chemico-Biological Interactions 178

      Pages: 110-116

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Investigation of the role of the amino acid residue at position 230 for catalysis in monomeric carbonyl reductase 32009

    • Author(s)
      Takeshi Miura, Yuma Itoh, Masahito Takada, Hidenobu Tsutsui, Tokihito Yukimura, Toru Nishinaka, Tomoyuki
    • Journal Title

      Chemico-Biological Interactions 178

      Pages: 211-214

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Different functions between human monomeric carbonyl reductase 3 and carbonyl reductase 1.2008

    • Author(s)
      Takeshi Miura, Toru Nishinaka, Masashi Takama, Masahiro Murakami, Tomoyuki Terada
    • Journal Title

      Molecular and Cellular Biochemistry 315(1-2)

      Pages: 113-121

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] 焦点心不全のディジーズマネジメント新しい疾病管理と患者支援[II]心不全のディジーズマネジメントの実践を探る2008

    • Author(s)
      米澤一也
    • Journal Title

      急性期急性増悪期の臨床薬理(看護技術10月臨時増刊号) 54(12)

      Pages: 56-61

    • Related Report
      2010 Final Research Report
  • [Journal Article] 急性心不全とその関連疾患に対する効果的かつ効率的な治療等の確立に関する臨床研究一院外心停止者の救命率向上に対する自動体外式除細動器を用いた心肺蘇生法の普及とエビデンス確立のためのウツタイン様式を用いた大規模研究2007

    • Author(s)
      米澤一也
    • Journal Title

      厚生労働科学研究費補助金による循環器疾患等生活習慣病対策総合研究事業:急性心不全とその関連疾患に対するより効果的かつ効率的な治療等の確立に関する臨床研究『院外心停止者の救命率向上に対する自動体外式除細動器を用いた心肺蘇生法の普及とエビデンス確立のためのウツタイン様式を用いた大規模研究』課題番号:H16-心筋-02平成18年度総括・分担研究報告書

      Pages: 25-26

    • Related Report
      2010 Final Research Report
  • [Presentation] ラット腎虚血再灌流障害に対する内因性モノアミンオキシダーゼ阻害物質イサチンの効果(The effect of an endogenous monoamine oxidase inhibitor, isatin, on ischemia/reperfusion-induced renal injury in rats)2010

    • Author(s)
      三浦健、筒居秀伸、小渕修平、田中亮輔、山形雅代、大喜多守、松村靖夫、雪村時人、寺田知行
    • Organizer
      第130回日本薬学会年会
    • Place of Presentation
      岡山市
    • Year and Date
      2010-03-28
    • Related Report
      2010 Final Research Report
  • [Presentation] ラット腎虚血再灌流障害に対する内因性モノアミンオキシダーゼ阻害物質イサチンの効果(The effect of an endogenous monoamine oxidase inhibitor, isatin, on ischemia/reperfusion-induced renal injury in rats)2010

    • Author(s)
      三浦健、筒居秀伸、小渕修平、田中亮輔、山形雅代、大喜多守、松村靖夫、雪村時人、寺田知行
    • Organizer
      第130回日本薬学会年会
    • Place of Presentation
      岡山市 岡山コンベンションセンター
    • Year and Date
      2010-03-28
    • Related Report
      2009 Annual Research Report
  • [Presentation] ラットチオールトランスフェラーゼの変異導入による機能変化2010

    • Author(s)
      寺田知行 三浦健 西中徹
    • Organizer
      第83回日本生化学会・第33回日本分子生物学会合同年会
    • Place of Presentation
      神戸市
    • Related Report
      2010 Final Research Report
  • [Presentation] 転写因子Nrf2によるアルドーケト還元酵素AKRIB10遺伝子の発現調節2010

    • Author(s)
      西中徹 奥村麻奈美 中尾文香 中村遥香 三浦健 寺田知行
    • Organizer
      第83回日本生化学会・第33回日本分子生物学会合同年会
    • Place of Presentation
      神戸市
    • Related Report
      2010 Final Research Report
  • [Presentation] Regulation of Aldo-keto reductase 1B10 (AKR1B10) gene expression2010

    • Author(s)
      Toru Nishinaka, Takeshi Miura, Tomoyuki Terada
    • Organizer
      15th International workshop on Enzymology and Molecular Biology of Carbonyl Metabolism
    • Place of Presentation
      アメリカ
    • Related Report
      2010 Final Research Report
  • [Presentation] Regulation of Aldo-keto reductase 1B10 (AKR1B10) gene expression2010

    • Author(s)
      Toru Nishinaka, Takeshi Miura, Tomoyuki Terada
    • Organizer
      15th International workshop on Enzymology and Molecular Biology of Carbonyl Metabolism
    • Place of Presentation
      Lexington, Kentucky, USA
    • Related Report
      2010 Annual Research Report
  • [Presentation] 転写因子Nrf2によるアルドーケト還元酵素AKR1B10遺伝子の発現調節2010

    • Author(s)
      西中徹, 奥村麻奈美, 中尾文香, 中村遥香, 三浦健, 寺田知行
    • Organizer
      第83回日本生化学会・第33回日本分子生物学会合同年会
    • Place of Presentation
      神戸
    • Related Report
      2010 Annual Research Report
  • [Presentation] ラットチオールトランスフェラーゼの変異導入による機能変化2010

    • Author(s)
      寺田知行, 三浦健, 西中徹
    • Organizer
      第83回日本生化学会・第33回日本分子生物学会合同年会
    • Place of Presentation
      神戸
    • Related Report
      2010 Annual Research Report
  • [Presentation] Potential targeting region for the specific inhibition of human monomeric carbonyl reductases of the short-chain dehydrogenase/reductase superfamily.2009

    • Author(s)
      Takeshi Miura, Toru Nishinaka, Tomoyuki Terada
    • Organizer
      3rd Asian Pacific Regional Meeting (ISSX)
    • Place of Presentation
      バンコク、タイ
    • Year and Date
      2009-05-10
    • Related Report
      2010 Final Research Report
  • [Presentation] Potential targeting region for the specific inhibition of human monomeric carbonyl reductases of the short-chain dehydrogenase/reductase superfamily2009

    • Author(s)
      Takeshi Miura, Toru Nishinaka, Tomoyuki Terada
    • Organizer
      3rd Asian Pacific Regional Meeting(ISSX)
    • Place of Presentation
      Bangkok, Thailand
    • Year and Date
      2009-05-10
    • Related Report
      2009 Annual Research Report
  • [Book] 指導士資格認定試験準拠心臓リハビリテーション必携(2.代謝機能・骨格筋機能) (全346ページ)2010

    • Author(s)
      米澤一也
    • Publisher
      特定非営利活動法人日本心臓リハビリテーション学会編発行
    • Related Report
      2010 Final Research Report
  • [Book] 3章心臓リハビリテーションの理解に役立っTips.1病態生理・疫学Q39心臓が悪くなると骨格筋も悪くなる?-心不全時の骨格筋変化、(心臓リハビリテーション知っておくべきTips) (全275ページ)2008

    • Author(s)
      米澤一也
    • Publisher
      中山書店発行
    • Related Report
      2010 Final Research Report
  • [Book] ECC(EmergencyCardiovascularCare)超急性期をのりこえる(第1章急性心筋梗塞症の疫学発症における性差-女性での知見と中心として) (全308ページ)2007

    • Author(s)
      米澤一也
    • Publisher
      中山書店発行
    • Related Report
      2010 Final Research Report
  • [Book] 説明上手なナースになる!心臓病患者さんの生活・退院指導、(第1章心臓病の予防、検査、2.理学的所見) (全262ページ)2006

    • Author(s)
      米澤一也、北畠顕
    • Publisher
      メディカ出版発行
    • Related Report
      2010 Final Research Report

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Published: 2008-03-31   Modified: 2016-04-21  

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