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Clinicopathological features of malignant lymphoma in Japan : Miyagi Study

Research Project

Project/Area Number 20590555
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Laboratory medicine
Research InstitutionTohoku University

Principal Investigator

ICHINOHASAMA Ryo  Tohoku University, 大学院・医学系研究科, 教授 (30184625)

Project Period (FY) 2008 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2009: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2008: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Keywords臨床血液学 / 悪性リンパ腫 / 疫学 / 宮城県 / CD20 / BACH2 / 悪性リパ腫
Research Abstract

A total of 1,552 cases of newly diagnosed malignant lymphoma in Miyagi prefecture between 2002 and 2008 were enrolled in this epiemiological study. The rate of follicular lymphoma (24%) was higher than that in previous reports from Asian countries, and similar to that in Western countries. The analysis of each subtype of B-cell lymphoma revealed the incidence for lack of CD20 expression by either flow cytometry or immunohistochemistry (4% or 4%) and the discrepancy of CD20 expression between the results of flow-cytometry and immunohistochemistry (6.3%).

Report

(4 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report
  • 2008 Annual Research Report
  • Research Products

    (55 results)

All 2011 2010 2009 2008

All Journal Article (45 results) (of which Peer Reviewed: 37 results) Presentation (8 results) Book (2 results)

  • [Journal Article] Clinicopathological Features of Malignant Lymphoma in Japan : The Miyagi Study.2011

    • Author(s)
      Miura Y, Fukuhara N, Yamamoto J, Ishizawa K, Ichinohasama R, Harigae H.
    • Journal Title

      Tohoku J Exp Med in press

    • NAID

      10028234244

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Successful treatment with bortezomib and thalidomide for POEMS syndrome.2011

    • Author(s)
      Ohguchi H, Ohba R, Ichinohasama R, et al.
    • Journal Title

      Ann Hematol.

      Volume: 未定(掲載確定)

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Successful treatment with bortezomib and thalidomide for POEMS syndrome.2010

    • Author(s)
      Ohguchi H, Fukuhara N, Yamamoto J, Ishizawa K, Ichinohasama R, Harigae H.
    • Journal Title

      Ann Hematol. [Epub ahead of print]

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Japanese case of follicular lymphoma of ocular adnexa diagnosed by clinicopathologic, immunohistochemical, and molecular genetic techniques.2010

    • Author(s)
      Otomo T, Ishizawa K, Ichinohasama R.
    • Journal Title

      Clin Ophthalmol. 4

      Pages: 1397-1402

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Differential diagnosis of angioimmunoblastic T-cell lymphoma with seropositivity for anti-HTLV antibody from adult T-cell leukemia/lymphoma.2010

    • Author(s)
      Chuang SS, Ichinohasama R, Ohshima K.
    • Journal Title

      Int J Hematol. 91

      Pages: 687-691

    • NAID

      10026402228

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Sensitive immunohistochemical detection of WT1 protein in tumors with anti-WT1 antibody against WT1 235 peptide.2010

    • Author(s)
      Ichinohasama R, Ishizawa K, Sugiyama H.
    • Journal Title

      Cancer Sci. 101

      Pages: 1089-1092

    • NAID

      10026591723

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Angioimmunoblastic T-cell lymphoma and membranous nephropathy : a still unreported association.2010

    • Author(s)
      Togashi M, Ichinohasama R, Sawada K.
    • Journal Title

      Clin Exp Nephrol. 14

      Pages: 288-293

    • NAID

      10027706470

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Multicentric primary intestinal EBV-positive diffuse large B cell lymphoma of the elderly presenting with perforation.2010

    • Author(s)
      Chuang SS, Ichinohasama R, Lin SH.
    • Journal Title

      Int J Hematol. 91

      Pages: 534-538

    • NAID

      10026401532

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Extreme eosinophilia caused by interleukin-5-producing disseminated colon cancer.2010

    • Author(s)
      Kato H, Yamamoto J, Ishizawa K, Ichinohasama R, Harigae H.
    • Journal Title

      Int J Hematol. 91

      Pages: 328-330

    • NAID

      10026111698

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] A case of intravascular large B-cell lymphoma of the cutaneous variant : the first case in Asia.2010

    • Author(s)
      Kameoka Y, Ichinohasama R, Sawada K.
    • Journal Title

      Int J Hematol. 91

      Pages: 146-148

    • NAID

      10026110947

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] 宮城県における悪性リンパ腫の調査研究2010

    • Author(s)
      張替秀郎、一迫玲
    • Journal Title

      MIYAGI Study血液・腫瘍科 60

      Pages: 83-88

    • Related Report
      2010 Final Research Report
  • [Journal Article] Multicentric primary intestinal EBV-positive diffuse large B cell lymphoma of the elderly presenting with perforation.2010

    • Author(s)
      Chuang SS, Ichinohasama R, et al.
    • Journal Title

      Int J Hematol

      Volume: 91 Pages: 534-538

    • NAID

      10026401532

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Angioimmunoblastic T-cell lymphoma and membranous nephropathy : a still unreported association.2010

    • Author(s)
      Togashi M, Wakui H, Ichinohasama R, et al.
    • Journal Title

      Clin Exp Nephrol

      Volume: 14 Pages: 288-293

    • NAID

      10027706470

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Sensitive immunohistochemical detection of WT1 protein in tumors with anti-WT1 antibody against WT1 235 peptide.2010

    • Author(s)
      Ichinohasama R, et al.
    • Journal Title

      Cancer Science

      Volume: 101 Pages: 1089-1098

    • NAID

      10026591723

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Differential diagnosis of angioimmunoblastic T-cell lymphoma with seropositivity for anti-HTLV antibody from adult T-cell leukemia/lymphoma.2010

    • Author(s)
      Chuang SS, Ichinohasama R, et al.
    • Journal Title

      Int J Hematol

      Volume: 91 Pages: 687-691

    • NAID

      10026402228

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Japanese case of follicular lymphoma of ocular adnexa diagnosed by clinicopathologic, immunohistochemical, and molecular genetic techniques.2010

    • Author(s)
      Otomo T, Fuse N, Ichinohasama R, et al.
    • Journal Title

      Clin Ophthalmol.

      Volume: 4 Pages: 1397-1402

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A case of intravascular large B-cell lymphoma of the cutaneous variant : the first case in Asia2010

    • Author(s)
      Kameoka Y, Takahashi N, Ichinohasama R, et al.
    • Journal Title

      Int J Hematol 91

      Pages: 146-148

    • NAID

      10026110947

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Extreme eosinophilia caused by interleukin-5-producing disseminated colon cancer2010

    • Author(s)
      Kato H, Kohata K, Ichinohasama R, et al.
    • Journal Title

      Int J Hematol 91

      Pages: 328-330

    • NAID

      10026111698

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 宮城県における悪性リンパ腫の調査研究:MIYAGI Study2010

    • Author(s)
      張替秀郎, 一迫玲
    • Journal Title

      血液・腫瘍科 60

      Pages: 83-88

    • NAID

      40019064727

    • Related Report
      2009 Annual Research Report
  • [Journal Article]2010

    • Author(s)
      中村栄男、飯田真介、大島孝一、木下朝博、吉野正、一迫玲, ほか
    • Journal Title

      WHO血液腫瘍分類(医薬ジャーナル社)

    • Related Report
      2009 Annual Research Report
  • [Journal Article] EBV-associated diffuse large B-cell lymphoma in a psoriatic treated with methotrexate.2009

    • Author(s)
      Hsiao SC, Ichinohasama R, Chuang SS.
    • Journal Title

      Pathol Res Pract. 205

      Pages: 43-49

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Kidney-limited intravascular large B cell lymphoma : a distinct variant of IVLBCL?2009

    • Author(s)
      Kameoka Y, Ichinohasama R, Sawada K.
    • Journal Title

      Int J Hematol. 89

      Pages: 533-537

    • NAID

      10025161506

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Adult T-cell leukemia/lymphoma comprising non-floral leukemic cells in Taiwan, a country non-endemic for human T-cell leukemia virus type I.2009

    • Author(s)
      Hsieh YC, Ichinohasama R, Chuang SS.
    • Journal Title

      Leuk Lymphoma. 50

      Pages: 1540-1542

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Aberrant overexpression of microRNAs activate AKT signaling via down-regulation of tumor suppressors in natural killer-cell lymphoma/leukemia.2009

    • Author(s)
      Yamanaka Y, Ichinohasama R, Sawada K.
    • Journal Title

      Blood. 114

      Pages: 3265-3275

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Plasma cell leukemia producing monoclonal immunoglobulin E.2009

    • Author(s)
      Takemura Y, Ichinohasama R.
    • Journal Title

      Int J Hematol. 90

      Pages: 402-406

    • NAID

      10026109150

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Peripheral T cell lymphoma with a high titer of proteinase-3-antineutrophil cytoplasmic antibodies that resembled Wegener's granulomatosis.2009

    • Author(s)
      Shirai T, Yamamoto J, Ishizawa K, Ichinohasama R, Harigae H.
    • Journal Title

      Intern Med. 48

      Pages: 2041-2045

    • NAID

      130000122235

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] フローサイトメトリーによる悪性リンパ腫の診断2009

    • Author(s)
      一迫玲
    • Journal Title

      血液・腫瘍科 59

      Pages: 642-651

    • Related Report
      2010 Final Research Report 2009 Annual Research Report
  • [Journal Article] Aberrant overexpression of microRNAs activate AKT signaling via down-regulation of tumor suppressors in natural killer-cell lymphoma/leukemia2009

    • Author(s)
      Yamanaka Y, Tagawa H, Ichinohasama R, et al.
    • Journal Title

      Blood 114

      Pages: 3265-3275

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Kidney-limited intravascular large B cell lymphoma : a distinct variant of IVLBCL?2009

    • Author(s)
      Kameoka Y, Takahashi N, Ichinohasama R, et al.
    • Journal Title

      Int J Hematol 89

      Pages: 533-537

    • NAID

      10025161506

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Adult T-cell leukemia/lymphoma comprising non-floral leukemic cells in Taiwan, a country non-endemic for human T-cell leukemia virus type I2009

    • Author(s)
      Hsieh YC, Chang ST, Ichinohasama R, et al.
    • Journal Title

      Leuk Lymphoma 50

      Pages: 1540-1542

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Plasma cell leukemia producing monoclonal immunoglobulin E2009

    • Author(s)
      Takemura Y, Ikeda M, Ichinohasama R, et al.
    • Journal Title

      Int J Hematol 92

      Pages: 402-406

    • NAID

      10026109150

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Peripheral T cell lymphoma with a high titer of proteinase-3-antineutrophil cytoplasmic antibodies that resembled Wegener's granulomatosis2009

    • Author(s)
      Shirai T, Takahashi R, Ichinohasama R, et al.
    • Journal Title

      Intern Med 48

      Pages: 2041-2045

    • NAID

      130000122235

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article]2009

    • Author(s)
      飛内賢正、堀田知光、木下朝博、一迫玲, ほか
    • Journal Title

      悪性リンパ腫治療マニュアル(南江堂)

    • Related Report
      2009 Annual Research Report
  • [Journal Article] EBV-associated diffuse large B-cell lymphoma in a psoriatic treated with methotrexate2009

    • Author(s)
      Hsiao SC, Ichinohasama R, et.al.
    • Journal Title

      Pathol Res Pract 205

      Pages: 43-49

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Rapidly growing cobblestone-like nodules as a manifestation of myeloid sarcoma.2008

    • Author(s)
      Nakagawa S, Ichinohasama R, Aiba S.
    • Journal Title

      Acta Derm Venereol. 88

      Pages: 633-634

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] HHV-8/KSHV-negative and CD20-positive primary effusion lymphoma successfully treated by pleural drainage followed by chemotherapy containing rituximab.2008

    • Author(s)
      Terasaki Y, Ichinohasama R, Ishida Y.
    • Journal Title

      Intern Med. 47

      Pages: 2175-2178

    • NAID

      130000079781

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Predominant tubulointerstitial nephritis in a patient with systemic lupus erythematosus : phenotype of infiltrating cells.2008

    • Author(s)
      Omokawa A, Ichinohasama R, Sawada K.
    • Journal Title

      Clin Nephrol. 69

      Pages: 436-444

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] De novo CD5+ diffuse large B-cell lymphoma : results of a detailed clinicopathological review in 120 patients.2008

    • Author(s)
      Yamaguchi M, Ichinohasama R, Nakamura S.
    • Journal Title

      Haematologica. 93

      Pages: 1195-1202

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Cytogenetic abnormality 46, XX, add(21)(q11.2) in a patient with follicular dendritic cell sarcoma.2008

    • Author(s)
      Suzuki N, Ishizawa K, Ichinohasama R.
    • Journal Title

      Cancer Genet Cytogenet. 186

      Pages: 54-57

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] 頚部リンパ節の腫脹をきたす疾患の鑑別(口腔病理から)2008

    • Author(s)
      一迫玲
    • Journal Title

      日本口腔外科学会雑誌 54

      Pages: 480-483

    • Related Report
      2010 Final Research Report 2008 Annual Research Report
  • [Journal Article] 免疫学的表現型解析-免疫組織化学とフローサイトメトリー2008

    • Author(s)
      一迫玲
    • Journal Title

      内科 102

      Pages: 239-246

    • Related Report
      2010 Final Research Report 2008 Annual Research Report
  • [Journal Article] 細胞表面マーカー2008

    • Author(s)
      一迫玲
    • Journal Title

      日本内科学会雑誌 97

      Pages: 41-48

    • NAID

      10021930517

    • Related Report
      2010 Final Research Report 2008 Annual Research Report
  • [Journal Article] HHV-8/KSHV-negative and CD20-positive primary effusion lymphoma successfully treated by pleural drainage followed by chemotherapy containing rituximab2008

    • Author(s)
      Terasaki Y, Okumura H, Saito K, Ichinohasama R, et.al.
    • Journal Title

      Intern Med 47

      Pages: 2175-2178

    • NAID

      130000079781

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Cytogenetic abnormality 46, XX, add(21)(q11.2) in a patient with follicular dendritic cell sarcoma2008

    • Author(s)
      Suzuki N, Ichinohasama R., et.al.
    • Journal Title

      Cancer Genet Cytogenet 186

      Pages: 54-57

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] De novo CD5+ diffuse large B-cell lymphoma : results of a detailed clinicopathological review in 120 patients2008

    • Author(s)
      Yamaguchi M, Nakamura N., Ichinohasama R., et.al.
    • Journal Title

      Haematologica 93

      Pages: 1195-1202

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Presentation] Enteropathy-associated T-cell lymphoma : a clinicopathological analysis from MIYAGI study group2010

    • Author(s)
      福原規子, 一迫玲, 他
    • Organizer
      日本血液学会総会
    • Place of Presentation
      横浜
    • Year and Date
      2010-09-25
    • Related Report
      2010 Final Research Report
  • [Presentation] Primary systemic plasmacytoma of lymph nodes succesfully treated by autologous PBSCT2010

    • Author(s)
      遠宮靖雄、一迫玲, ほか
    • Organizer
      日本血液学会総会
    • Place of Presentation
      横浜市
    • Year and Date
      2010-09-25
    • Related Report
      2010 Annual Research Report
  • [Presentation] Enteropathy-associated T-cell lymphoma : a clinicopathological analysis from MIY AGI study group2010

    • Author(s)
      福原規子、一迫玲, ほか
    • Organizer
      日本血液学会総会
    • Place of Presentation
      横浜市
    • Year and Date
      2010-09-25
    • Related Report
      2010 Annual Research Report
  • [Presentation] Comparison of phenotypes between t (14;18)-positive and negative follicular lymphoma2010

    • Author(s)
      三浦由希子, 一迫玲, 他
    • Organizer
      日本臨床腫瘍学会総会
    • Place of Presentation
      東京
    • Year and Date
      2010-03-19
    • Related Report
      2010 Final Research Report
  • [Presentation] FISH法によるIgH転座解析を用いた濾胞性リンパ腫骨髄浸潤の検出2009

    • Author(s)
      木幡桂, 一迫玲, 他
    • Organizer
      日本血液学会総会
    • Place of Presentation
      京都
    • Year and Date
      2009-10-25
    • Related Report
      2010 Final Research Report
  • [Presentation] 宮城県における悪性リンパ腫の臨床及び病理学的特徴2009

    • Author(s)
      三浦由希子, 一迫玲, 他
    • Organizer
      日本血液学会総会
    • Place of Presentation
      京都
    • Year and Date
      2009-10-25
    • Related Report
      2010 Final Research Report
  • [Presentation] 宮城県における悪性リンパ腫の臨床及び病理学的特徴2009

    • Author(s)
      三浦由希子、一迫玲, ほか
    • Organizer
      日本血液学会総会
    • Place of Presentation
      京都市
    • Year and Date
      2009-10-25
    • Related Report
      2009 Annual Research Report
  • [Presentation] FISH法によるIgH転座解析を用いた濾胞性リンパ腫骨髄浸潤の検出2009

    • Author(s)
      木幡桂、一迫玲, ほか
    • Organizer
      日本血液学会総会
    • Place of Presentation
      京都市
    • Year and Date
      2009-10-25
    • Related Report
      2009 Annual Research Report
  • [Book] WHO血液腫瘍分類2010

    • Author(s)
      一迫玲, 他
    • Publisher
      医薬ジャーナル社
    • Related Report
      2010 Final Research Report
  • [Book] 悪性リンパ腫治療マニュアル2009

    • Author(s)
      一迫玲, 他
    • Publisher
      南江堂
    • Related Report
      2010 Final Research Report

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Published: 2008-04-01   Modified: 2016-04-21  

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