| Project/Area Number |
20590558
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Laboratory medicine
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| Research Institution | Juntendo University |
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Principal Investigator |
MIIDA Takashi Juntendo University, 医学部, 教授 (80260545)
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| Co-Investigator(Kenkyū-buntansha) |
OKADA Masahiko 新潟大学, 医歯学系, 教授 (30018915)
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| Research Collaborator |
HIRAYAMA Satoshi 順天堂大学, 医学部, 准教授
CHIBA Hitoshi 北海道大学, 大学院・保健科学研究院, 教授 (70197622)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2009: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2008: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | 慢性透析患者 / リン脂質 / 酸化ストレス / HDL / 動脈硬化 |
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| Research Abstract |
Oxidized LDL accumulates in macrophages, while HDL prevents the development of atherosclerosis. This study aimed at examining the relationship between oxidized phospholipids (PL) and impaired HDL function. We collected blood samples from hemodialysis (HD) patients, who have increased oxidative stress and high susceptibility to atherosclerosis. In the HD patients, serum PL concentration was low, but oxidized PL concentration and PL transfer activity increased significantly. In these patients, LCAT-dependent maturation of prebeta1-HDL, small HDL particles, was impaired. In summary, it is suggested that oxidized PL might be transferred from LDL to HDL, and cause impairment of HDL maturation.
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