Evaluation of Aspirin Resistance in Aspirin-Free Patients with Severe Type-2 Diabetes Mellitus
| Project/Area Number |
20590562
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Laboratory medicine
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| Research Institution | University of Yamanashi |
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Principal Investigator |
TAKANO Katsuhiro University of Yamanashi, 医学部附属病院, 助教 (60382925)
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| Co-Investigator(Kenkyū-buntansha) |
OZAKI Yukio 山梨大学, 大学院・医学工学総合研究部, 教授 (30134539)
SATOH Kaneo 山梨大学, 医学部, 助手 (20242662)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2010: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2009: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2008: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Keywords | 臨床血液学 / 血小板 / アスピリン抵抗性 / 糖尿病 / 血小板機能評価 / 薬剤反応性 / 血栓症予防 / アスピリン |
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| Research Abstract |
Platelet aspirin sensitivity assessed by COX-1 activity in severe DM patients was the same as in healthy individuals, which denies the hypothesis that high blood glucose levels interfere with aspirin acetylation of the COX-1 active site. On the other hand, some individuals who showed strong platelet aggregation at high aspirin dose despite their almost complete inhibition of TxA2 production were observed only in the DM group. Such "high residual platelet responsiveness" was corrected by adding P2Y12 receptor blocker, suggesting that P2Y12 blocker in addition to aspirin might be beneficial for selected DM patients.
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Report
(4 results)
Research Products
(7 results)
