Pathogensis of H. heilmannii-related gastric mucosal legions
| Project/Area Number |
20590564
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Laboratory medicine
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| Research Institution | Shinshu University |
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Principal Investigator |
OTA Hiroyoshi Shinshu University, 医学部, 教授 (50273107)
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| Co-Investigator(Kenkyū-buntansha) |
KOBAYASHI Motohiro 信州大学, 医学系研究科, 講師 (00362137)
KAWAKAMI Yoshiyuki 信州大学, 医学部, 教授 (90283275)
SANO Kenji 信州大学, 医学部附属病院, 講師 (50205994)
藤田 清貴 信州大学, 医学部, 准教授 (90313866)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2010: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2009: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2008: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | ヘリコバクター・ハイルマニ / Helicobacter heilmannii / MALTリンパ腫 |
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| Research Abstract |
(1) Chronic gastritis and MALT lymphoma developed in the H. heilmannii-infected BALB/c mice. HEV-like vessels expressing GlcNAc6ST-1-mediated L-selectin ligand carbohydrate and MAdCAM-1 may play a crucial role in the pathogenesis of H. heilmannii-induced chronic gastritis and MALT lymphoma. (2) In culturing H. felis strains, the optimal condition for obtaining cells with the largest colony sizes or for obtaining the highest percentage of spiral forms were demonstrated. (3) Taxonomic analysis of clinically isolated H. heimannii strains disclosed that H. heilmannii SH6 represents a novel strain and should constitute a novel taxon in the phylogenetic trees.
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Report
(4 results)
Research Products
(34 results)
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[Journal Article] Helicobacter heilmannii" can induce gastric lymphoid follicles in mice via a Peyer' s Patch independent pathway2010
Author(s)
Nobutani K, Yoshida M, Nishiumi S, Nishitani Y, Takagawa T, Tanaka H, Yamamoto K, Mimura T, Bensleiman Y, Ota Takahashi S, Matsui H, Nakamura M, Azuma T
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Journal Title
FEMS Immunol Med Microbiol 60
Pages: 156-164
Related Report
Peer Reviewed
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[Journal Article] Japanese Society for Helicobacter Research.2010
Author(s)
Asaka M, Kato M, Takahashi S, Fukuda Y, Sugiyama T, Ota H, Uemura N, Murakami K, Satoh K, Sugano K
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Journal Title
Guidelines for the management of Helicobacter pylori infection in Japan : 2009 revised edition, Helicobacter 15
Pages: 1-20
Related Report
Peer Reviewed
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[Journal Article] Helicobacter heilmannii" can induce gastric lymphoid follicles in micevia a Peyer's Patch independent pathway.2010
Author(s)
Nobutani K, Yoshida M, Nishiumi S, Nishitani Y, Takagawa T, Tanaka H, Yamamoto K, Mimura T, Bensleiman Y, Ota H, Takahashi S, Matsui H, Nakamura M, Azuma T
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Journal Title
FEMS Immunol Med Microbiol
Volume: 60
Pages: 156-164
Related Report
Peer Reviewed
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[Journal Article] 日本ヘリコバクター学会ガイドライン作成委員会2009
Author(s)
浅香正博, 菅野健太郎, 高橋信一, 福田能啓, 杉山敏郎, 太田浩良, 上村直実, 村上和成, 佐藤貴一, 加藤元嗣
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Journal Title
日本ヘリコバクター学会"H.pylori感染の診断と治療のガイドライン"2009改訂版, 日本ヘリコバクター学会誌 10巻
Pages: 104-128
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[Journal Article] 胃MALTリンパ腫の内視鏡所見 早期胃癌や胃炎との鑑別診断2009
Author(s)
赤松泰次, 北原桂, 白川晴章, 市川真也, 長屋匡信, 須藤貴森, 武田龍太郎, 竹中一弘, 太田浩良, 宮林秀晴, 田中榮司
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