| Project/Area Number |
20590564
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Laboratory medicine
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| Research Institution | Shinshu University |
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Principal Investigator |
OTA Hiroyoshi Shinshu University, 医学部, 教授 (50273107)
|
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| Co-Investigator(Kenkyū-buntansha) |
KOBAYASHI Motohiro 信州大学, 医学系研究科, 講師 (00362137)
KAWAKAMI Yoshiyuki 信州大学, 医学部, 教授 (90283275)
SANO Kenji 信州大学, 医学部附属病院, 講師 (50205994)
藤田 清貴 信州大学, 医学部, 准教授 (90313866)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2010: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2009: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2008: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | ヘリコバクター・ハイルマニ / Helicobacter heilmannii / MALTリンパ腫 |
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| Research Abstract |
(1) Chronic gastritis and MALT lymphoma developed in the H. heilmannii-infected BALB/c mice. HEV-like vessels expressing GlcNAc6ST-1-mediated L-selectin ligand carbohydrate and MAdCAM-1 may play a crucial role in the pathogenesis of H. heilmannii-induced chronic gastritis and MALT lymphoma. (2) In culturing H. felis strains, the optimal condition for obtaining cells with the largest colony sizes or for obtaining the highest percentage of spiral forms were demonstrated. (3) Taxonomic analysis of clinically isolated H. heimannii strains disclosed that H. heilmannii SH6 represents a novel strain and should constitute a novel taxon in the phylogenetic trees.
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