Analyze the mechanism of onset of Graves' disease, using high sensitivity method for TSH receptor antibody
| Project/Area Number |
20590569
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Laboratory medicine
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| Research Institution | Osaka University |
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Principal Investigator |
HIDAKA Yoh Osaka University, 医学系研究科, 准教授 (30243231)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2009: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2008: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | TSHレセプター抗体 / バセドウ病 / スギ花粉症 / アレルギー性鼻炎 |
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| Research Abstract |
The peripheral blood mononuclear cells (PBMC) from the Graves' patients complicated with cedar pollen allergy were stimulated with cedar pollen. TSH receptor antibody (TRAb) could be detected in the supernatant using high sensitivity method. However, TRAb also could be detected in the supernatant incubated without the stimulation of cedar pollen. Moreover, TRAb could be detected in the supernatant incubated PBMC from the Graves' patients without cedar pollen allergy. Therefore, we could not demonstrate that the cedar pollen stimulates the production of TRAb.
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Report
(4 results)
Research Products
(37 results)
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[Journal Article] Increased expression levels of tensin3 mRNA in thyroid functional adenomas as compared to non-functioning adenomas.2009
Author(s)
Maeda I, Yamada H, Takano T, Nishihara E, Ito Y, Matsuzuka F, Miya A, Kobayashi K, Yoshida H, Miyauchi A, Hidaka Y.
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Journal Title
Exp Clin Endocr Diab 117
Pages: 191-193
Related Report
Peer Reviewed
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