Physiological role of 11-dehydrothromboxane B2 : parameter of platelet activity and aspirin resistance
| Project/Area Number |
20590573
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Laboratory medicine
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| Research Institution | Okayama University |
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Principal Investigator |
MATSUURA Eiji (2009-2010) Okayama University, 大学院・医歯薬学総合研究科, 教授 (20181688)
小林 和子 (2008) Okayama University, 大学院・医歯薬学総合研究科, 非常勤研究員 (20304298)
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| Co-Investigator(Kenkyū-buntansha) |
NISHII Nobuhiro 岡山大学, 病院, 助教 (50537214)
松浦 栄次 岡山大学, 医歯薬学総合研究科, 准教授 (20181688)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2010: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2009: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2008: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | トロンボキサンB2 / 血小板機能 / 疾患モデルマウス / アスピリン抵抗性 / 動脈硬化 / 酸化LDL / アスピリン不応答性 / 抗リン脂質抗体症候群 |
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| Research Abstract |
Aspirin prevents platelet aggregation by irreversible acetylation of cyclooxygenase. We evaluated the usefulness of an enzyme-linked immunosorbent assay (ELISA) to determine levels of 11-dehydrothromboxane B2 in urine, which aids in the detection of aspirin effect post ingestion. In low-density lipoprotein receptor-deficient mice fed with a high fat diet and received aspirin, urinary 11-dehydrothromboxane B2 (11-dhTXB2) tended to decrease and atherosclerotic plaque area significantly decreased.
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Report
(4 results)
Research Products
(20 results)
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[Journal Article] Persimmon (Diospyros Kaki Thunb 'Saijo') peel improved dyslipidemia and its related production of atherogenic autoantigen complexes in low-density lipoprotein receptor-deficient mice.2011
Author(s)
Quan N, Kobayashi K, Matsunami Y, Ide M, Makarova M, Shen L, Ohno S, Zheng Y, Kobayashi H, Lopez LR, Matsuura E.
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Journal Title
The Open Nutrition Journal
Volume: (in press)
Related Report
Peer Reviewed
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