Application of ischemia modified albumin as an indicator of hypoxia

• Project/Area Number: 20590585
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Laboratory medicine
• Research Institution: Showa University
• Principal Investigator: KIMURA Satoshi 昭和大学, 医学部, 准教授 (30255765)
• Project Period (FY): 2008 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000); Fiscal Year 2012: ¥390,000 (Direct Cost: ¥300,000、Indirect Cost: ¥90,000); Fiscal Year 2011: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000); Fiscal Year 2010: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000); Fiscal Year 2009: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000); Fiscal Year 2008: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
• Keywords: IMA / アルブミン / 虚血 / 慢性呼吸不全 / paraoxonase1 / sRAGE / parapxonase-1 / 虚血変性アルブミン / 脳血管障害 / 慢性腎不全 / Paraoxonase-1 / 動脈硬化 / 慢性閉塞性肺疾患 / 呼吸不全 / 睡眠時無呼吸症候群 / 気管支喘息 / 低酸素血症

Research Abstract

Ischemia-modified albumin (IMA) is produced inside human body especially peripheral tissue during ischemic damage. We hypothesized IMA could be an indicator of hypoxia to increase during progress of respiratory disease. Assaying serum IMA obtained from 12 respiratory patients, we could not detect significant difference. However, other markers such as paraoxonase1 and soluble receptor for advanced glycation end-product seemed to be candidates of tissue ischemia and atherosclerosis.

Research Products

• [Journal Article] Circulating soluble RAGE increase after a cerebrovascular event (2013)
  • Author(s): Menini T, Kimura S
  • Journal Title: Clin Chem Lab Med Mar Volume: 13 Pages: 1-8
• [Journal Article] Circulating soluble RAGE increase after a cerebrovascular event. (2013)
  • Author(s): Menini T, et al
  • Journal Title: Clin Chem Lab Med. Volume: Mar13 Pages: 1-8
  • Peer Reviewed
• [Journal Article] Serum paraoxonase 1 (PON1) lactonase activity is lower in end-stage renal disease patients than in healthy control subjects and increases after hemodialysis (2011)
  • Author(s): Gugliucci A, Kimura S
  • Journal Title: Clin Chem Lab Med Volume: 49 Pages: 61-7
• [Journal Article] Changes on the physiological lactonase activity of serum paraoxonase 1 by a diet intervention for weight loss in healthy overweight and obese (2009)
  • Author(s): Kotani K.Kimura S., et al
  • Journal Title: J Clin Biochem Nutr 45 Pages: 329-34
  • Peer Reviewed
• [Journal Article] Short-term low calorie diet intervention reduces serum advanced glycation end products in healthy overweight or obese adults (2009)
  • Author(s): Kotani K.Kimura S., et al
  • Journal Title: Ann Nutr Metab 54 Pages: 197-201
  • Peer Reviewed
• [Journal Article] Reduced paraoxonase 1/arylesterase activity and its post-therapeutic increase in obstructive sleep apnea syndrome: a preliminary study. (2008)
  • Author(s): Kotani K, Kimura S, et al
  • Journal Title: Clin Chim Acta Volume: 395 Pages: 184-5
• [Journal Article] Reduced paraoxonase 1/arylesterase activity and its post-therapeutic increase in obstructive sleep apnea syndrome : A preliminary study. (2008)
  • Author(s): Kotani K, Gucliucci A, Kimura S
  • Journal Title: Clinica Chimica Acta 395 Pages: 184-185
  • Peer Reviewed
• [Journal Article] Reduced paraoxonase 1/arylesterase activity and its post-herapeutic increase in obstructive sleep apnea syndrome : a preliminary study (2008)
  • Author(s): Kotani K, Kimura S, et al
  • Journal Title: Clin Chim Acta 395 Pages: 184-5
  • Peer Reviewed
• [Presentation] Circulating soluble receptor for advanced glycation end products increases after a cerebrovascular accident and may be a marker for encephalic inflammation: a follow-up pilot study. (2012)
  • Author(s): Kimura S, Ikeda H, MeniniT, Caccavello R, Gugliucci A
  • Organizer: The 8th World Stroke Congress
  • Place of Presentation: Brasilia, Brazil
• [Presentation] Changes of Serum Paraoxonase-1 and Ischemia Modified Albumin Levels in Acute Cerebrovascular Damage (2012)
  • Author(s): Kimura S, Ikeda H, Menini T, Gugliucci A
  • Organizer: The 8th World Stroke Congress
  • Place of Presentation: Brasilia, Brazil
• [Presentation] Can we detect ischemic lesion in acute stage of cerebral infarction using Serum Paraoxonase-1 and Ischemia Modified Albumin Levels? (2012)
  • Author(s): Ikeda H, Matsumoto H, Kimura S, MeniniT, Gugliucci A
  • Organizer: The 8th World Stroke Congress
  • Place of Presentation: Brasilia, Brazil
• [Presentation] Circulating soluble receptor for advanced glycation end products increases after a cerebrovascular accident and may be a marker for encephalic inflammation: a follow-up pilot study (2012)
  • Author(s): Kimura S
  • Organizer: The 8th World Stroke Congress
  • Place of Presentation: Brasilia, Brasil
• [Presentation] Changes of Serum Paraoxonase-1 and Ischemia Modified Albumin Levels in Acute Cerebrovascular Damage. (2012)
  • Author(s): Kimura S
  • Organizer: The 8th World Stroke Congress
  • Place of Presentation: Brasilia, Brasil
• [Presentation] Electronic Medical Records : How Laboratory Can Contribute to Reduce Errors Errors and Infection Outbreak (2011)
  • Author(s): Kimura S
  • Organizer: 2011 American Society for Clinical Annual Meeting/World Association of Pathology and Laboratory Medicine 26th World Congress
  • Place of Presentation: Las Vegas, NV, USA
  • Year and Date: 2011-10-21
• [Presentation] How your clinical samples are prepared (2010)
  • Author(s): Kimura S
  • Organizer: Tuoro University Research Seminor
  • Place of Presentation: Tuoro University California, Mare Island, CA, USA
  • Year and Date: 2010-03-31
• [Presentation] Changes of Serum Paraoxonase-1 and Ischemia Modified Albumin Levels in Acute Cerebrovascular Damage, a Pilot Study (2010)
  • Author(s): Kimura S, Ikeda H, Menini T, Gugliucci A
  • Organizer: The 7thWorld Stroke Congress
  • Place of Presentation: COEX Center, Seoul, Korea
• [Presentation] Changes of Serum Paraoxonase-1 and Ischemia Modified Albumin Levels in Acute Cerebrovascular Damage, a Pilot Study. (2010)
  • Author(s): Kimura S, Ikeda H, Menini T, Gugliucci A
  • Organizer: The 7^<th> World Stroke Congress
  • Place of Presentation: Seoul, Korea
• [Presentation] Changes of Serum Paraoxonase-land Ischemia Modified Albumin Levels in Acute Cerebrovascular Damage, a Pilot Study. (2010)
  • Author(s): Kimura S, Ikeda H, Menini T, Gugliucci A
  • Organizer: The 7th World Stroke Congress
  • Place of Presentation: COEX Center, Seoul, Korea
• [Presentation] Changes on the physiological lactonase activity of serum paraoxonase-1 in healthy overweight and obese women after weight loss (2009)
  • Author(s): Gugliucci A, Kotani, Kimura S
  • Organizer: The 7thWorld Congress on Insulin Resistance
  • Place of Presentation: San Francisco, California, USA
• [Presentation] Ischemia modified albumin levels in obstructive sleep apneapatientsbeforeandaftertreatment:apilotstudy (2009)
  • Author(s): Gugliucci A, Kotani K, Kimura S
  • Organizer: The 7thWorld Congress on Insulin Resistance
  • Place of Presentation: San Francisco, California, USA
• [Presentation] The antioxidant enzyme serum paraoxinase-1 is not a serum acetylsalicylic esterase (2009)
  • Author(s): Teresita M, Gugliucci A, Kimura S, et a
  • Organizer: The 7th World Congress on Insulin Resistance
  • Place of Presentation: San Francisco, California, USA
• [Presentation] Changes on the physiological lactonase activity of serum paraoxonase-1 in healthy overweight and obese women after weight loss (2009)
  • Author(s): Gugliucci A, Kimura S, et al
  • Organizer: The 7th World Congress on Insulin Resistance
  • Place of Presentation: San Francisco, California. USA
• [Presentation] Ischemia modified albumin levels in obstructive sleep apnea patients before and after treatment : a pilot study (2009)
  • Author(s): Gugliucci A, Kimura S, et al
  • Organizer: The 7th World Congress on Insulin Resistance
  • Place of Presentation: San Francisco, California, USA
• [Presentation] Circulating advanced glycation peptides are higher in neonates than in adults : Role of kidney metabolism (2009)
  • Author(s): Gugliucci A, Kimura S, et al
  • Organizer: International Symposium on the Maillard Reaction
  • Place of Presentation: Palm Cove, Cairns, Queensland, Australia
• [Presentation] Serum ischemia-modifiedalbumin levels in obstructive sleep apnea syndrome; a pilot study (2008)
  • Author(s): Kimura S
  • Organizer: The 10th International Congress of the Asian Society of Clinical Pathology and Laboratory Medicine
  • Place of Presentation: Kempinski Hotel Khan Palace, Ulaanbaatar, Mongolia
• [Presentation] 睡眠時無呼吸症候群患者の血中ischemia-modified albumin濃度 (2008)
  • Author(s): 木村 聡、小谷和彦、津崎こころ、駒田一朗、坂根直樹、北舘克憲、鷹取明美、Alejandro C. Gugliucci
  • Organizer: 第55回日本臨床検査医学会学術集会
  • Place of Presentation: 名古屋国際会議場 臨床病理 56(補)152, 2008
• [Presentation] Serum ischemia-modifiedalbumin levels in obstructive sleep apnea syndrome; a pilot study. (2008)
  • Author(s): Kimura S, Kotani K, Gugliucci A
  • Organizer: The 10th International Congress of the Asian Society of Clinical Pathology and Laboratory Medicine
  • Place of Presentation: Ulaanbaatar, Mongolia
• [Presentation] 睡眠時無呼吸症候群患者の血中ischemia-modified albumin濃度 (2008)
  • Author(s): 木村聡、小谷和彦、Gugliucci A
  • Organizer: 第55回日本臨床検査医学会学術集会(臨床病理)
  • Place of Presentation: 名古屋国際会議場
• [Presentation] Serum ischemia-modifiedalbumin levels in obstructive sleep apnea syndrome : a pilot study (2008)
  • Author(s): Kimura S, Gugliucci A., et al
  • Organizer: The 10th International Congress of the Asian Society of Clinical Pathology and Laboratory Medicine
  • Place of Presentation: Ulan Bator, Mongolia
• [Presentation] 睡眠時無呼吸症候群患者の血中 ischemia-modified albumin 濃度 (2008)
  • Author(s): 木村聡、Gugliucci C, ほか
  • Organizer: 第55回日本臨床検査医学会学術集会
  • Place of Presentation: 名古屋国際会議場
• [Remarks] 患者さんにわかりやすく説明できる明確な成果がまとまり次第、病院のホームページ等で紹介してゆく予定である。
• [Remarks]
  • URL: http://tws.tu.edu/webdocs/biochemistry/aleiandro/Collaborations.html