Studies on the role of endogenous digitalis in electrolytes and blood pressure regulation
| Project/Area Number |
20590589
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Laboratory medicine
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| Research Institution | Kansai Medical University |
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Principal Investigator |
TAKAHASHI Hakuo Kansai Medical University, 医学部, 教授 (80094431)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2010: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2009: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2008: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | 脳・神経 / 高血圧 / バイオマーカー / 電解質代謝 / ジギタリス / 内因性ジギタリス / アルドステロン / 副腎 / 視床下部 / ナトリウム塩 / アンジオテンシンII / 培養細胞 |
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| Research Abstract |
Among a variety of endogenous digitalis, bufadienolides originally found in toads and now determined in humans were demonstrated to have their toxin types with biological functions. They increase with sodium-loading. Immortalized cell lines originated from adrenal-cortex and -medulla, and hypothalamic neurons were used to determine the origin and secretory mechanism of those bufadienolides and ouabain, and the active production was found. Collectively with our previous studies, I conclude that sodium metabolism is crucially involved in the pathogenesis of all types of hypertension ; thereby, brain renin-angiotensin-aldosterone system and ouabain are essentially implicated as players.
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Report
(4 results)
Research Products
(24 results)
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[Journal Article] Ca^<2+> Entry Mode of Na^+/Ca^<2+> Exchanger as A New Therapeutic Target for Heart Failure with Preserved Ejection Fraction.2011
Author(s)
Kamimura D, Ohtani T, Sakata Y, Mano T, Takeda Y, Tamaki S, Omori Y, Tsukamoto Y, Furutani K, Komiyama Y, Yoshika M, Takahashi H, Matsuda T, Baba A, Umemura S, Miwa T, Komuro I, Yamamoto K
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Journal Title
Eur Heart J. (Epub ahead of print)
Related Report
Peer Reviewed
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