| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2010: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2009: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2008: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Research Abstract |
Among a variety of endogenous digitalis, bufadienolides originally found in toads and now determined in humans were demonstrated to have their toxin types with biological functions. They increase with sodium-loading. Immortalized cell lines originated from adrenal-cortex and -medulla, and hypothalamic neurons were used to determine the origin and secretory mechanism of those bufadienolides and ouabain, and the active production was found. Collectively with our previous studies, I conclude that sodium metabolism is crucially involved in the pathogenesis of all types of hypertension ; thereby, brain renin-angiotensin-aldosterone system and ouabain are essentially implicated as players.
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