A new diagnostic approach of Alzheimer's Disease based on the conformational changes of Aβ in serum
| Project/Area Number |
20590592
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Laboratory medicine
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| Research Institution | Tokushima Bunri University |
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Principal Investigator |
MATSUNAGA Yoichi Tokushima Bunri University, 薬学部, 教授 (80239053)
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| Co-Investigator(Kenkyū-buntansha) |
YAMADA Tatsuo 福岡大学, 医学部, 教授 (50142211)
SUENAGA Midori 徳島文理大学, 薬学部, 助教 (00389181)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2010: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2009: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2008: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | アルツハイマー病 / アミロイド蛋白 / 加温 / 蛋白立体構造変化 / 血清診断 / ベータアミロイド / ブレーカーペプタイド / 記憶障害 / 血清アミロイド蛋白濃度 / アミロイド蛋白凝集抑制 / アミロイドベータ蛋白 / 診断法 / 立体構造変化 / 患者血清 / 温熱変化 / ブレーカーペプチド / アミロイド蛋白凝集 / アミロイドベータ / 血清診断法 / 蛋白質加温凝集 |
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| Research Abstract |
We clarified the conformational changes of amyloid protein in serum between from normal and Alzheimer's patients to the temperature within physiological limits. The former exhibited the sensitivity to temperature and the latter did not exhibit the sensitivity to temperature. The present study suggest a new approach to the diagnostics of Alzheimer's disease with serum.
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Report
(4 results)
Research Products
(34 results)
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[Journal Article] Alcohol drinking and risk of Parkinson's disease : a case-control study in Japan.2010
Author(s)
W.Fukushima, Y.Miyake, K.Tanaka, S.Sasaki, C.Kiyohara, Y.Tsuboi, T.Yamada, T.Oeda, T.Miki, N.Kawamura, N.Sakae, H.Fukuyama, Y.Hirota, M.Nagai, the Fukuoka Kinki Parkinson's Disease Study Group
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Journal Title
BMC Neurology 10
Pages: 111-111
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[Journal Article] Active and passive smoking and risk of Parkinson's disease.2010
Author(s)
K.Tanaka, Y.Miyake, W.Fukushima, S.Sasaki, C.Kiyohara, Y.Tsuboi, T.Yamada, T.Oeda, T.Miki, N.Kawamura, N.Sakae, H.Fukuyama, Y.Hirota, M.Nagai, the Fukuoka Kinki Parkinson's Disease Study Group
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Journal Title
Acta.Neurol.Scand. 122
Pages: 377-382
Related Report
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[Journal Article] Dietary intake of folate, vitamin B6, vitamin B12 and riboflavin and risk of Parkinson's disease : a case-control study in Japan.2010
Author(s)
K.Murakami, Y.Miyake, S.Sasaki, K.Tanaka, W.Fukushima, C.Kiyohara, Y.Tsuboi, T.Yamada, T.Oeda, T.Miki, N.Kawamura, N.Sakae, H.Fukuyama, Y.Hirota, M.Nagai, Fukuoka Kinki Parkinson's disease Study Group
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Journal Title
Br.J.Nutr 104
Pages: 757-764
Related Report
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[Journal Article] Case-control study of risk of Parkinson's disease in relation to hypertension, hypercholesterolemia, and diabetes in Japan.2010
Author(s)
Y.Miyake, T.Tanaka, W.Fukushima, S. Sasaki, C.Kiyohara, Y.Tsuboi, T.Yamada, T.Oeda, T.Miki, N.Kawamura, N.Sakae, H. Fukuyama, Y.Hirota, M.Nagai, the Fukuoka Kinki Parkinson's Disease Study Group
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Journal Title
J Neurol Sci. 293
Pages: 82-86
Related Report
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