| Project/Area Number |
20590599
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Hygiene
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| Research Institution | The Institute of Statistical Mathematics |
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Principal Investigator |
MATSUI Shigeyuki The Institute of Statistical Mathematics, データ科学研究系, 教授 (80305854)
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| Co-Investigator(Kenkyū-buntansha) |
MORITA Satoshi 横浜市立大学, 医学研究科, 教授 (60362480)
山中 竹春 国立病院機構九州がんセンター, 臨床研究部, 研究員 (00325466)
大門 貴志 兵庫医科大学, 医学部, 講師 (40372156)
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| Co-Investigator(Renkei-kenkyūsha) |
YAMANAKA Takeharu 九州がんセンター, 臨床研究部, 室長 (00325466)
DAIMON Takashi 兵庫医科大学, 医学部, 講師 (40372156)
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| Project Period (FY) |
2008 – 2010
|
| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2009: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2008: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | 医学統計 / ゲノム薬理学 / 個別化医療 / ゲノムワイド研究 / 分子診断法の開発 / マイクロアレー / 臨床研究の計画と解析 / 階層混合モデル / 遺伝子スクリーニング / 体外診断法の開発 / ベイズ流階層混合モデル |
|---|
| Research Abstract |
Development of molecular diagnostics is essential for establishing personalized medicine based on genetic characteristics of individual patients. In this research, we studied design and analysis of clinical studies for developing molecular diagnostics. In particular, we developed statistical methods for identifying molecular markers associated with clinical variables such as disease type, response to treatment, and survival outcomes, from a large pool of candidate molecular markers, making prediction systems using the identified molecular markers, and testing their clinical utility.
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