The evaluation of mineral oil immunological effects included in diesel fuel and of mechanism of the immunological effect
| Project/Area Number |
20590607
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Hygiene
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| Research Institution | University of Miyazaki |
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Principal Investigator |
KURODA Yoshiki University of Miyazaki, 医学部, 教授 (50234620)
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| Co-Investigator(Renkei-kenkyūsha) |
KUNUGIDA Naoki 産業医科大学, 産業保健学部, 准教授 (90178020)
HIRANO Seisiro 独立行政法人国立環境研究所, 環境リスク研究センター, 室長 (20150162)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2009: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2008: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Keywords | 産業中毒 / 自己抗体 / 鉱物油 / TCR / CD3ζ / SLE / T細胞レセプター / アルジニン / 炎症 |
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| Research Abstract |
In our study, The serum arginine was decreased in mouse with peritoneal injection of pristane. The cause of this reduction is inflammation in peritoneal cavity. At the same time, CD3ζ of T-cell was decreased. We evaluated the metabolic system of CD3ζ to analyze the mechanism of CD3ζ reduction. We concluded that the mechanism of CD3ζ reduction is due to decline of mRNA of CD3ζ. But I have not known about the influence of arginine to CD3ζ reduction. We need more study to clear the relationship between CD3ζ reduction and decreased arginine.
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Report
(4 results)
Research Products
(5 results)
