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The evaluation of mineral oil immunological effects included in diesel fuel and of mechanism of the immunological effect

Research Project

Project/Area Number 20590607
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Hygiene
Research InstitutionUniversity of Miyazaki

Principal Investigator

KURODA Yoshiki  University of Miyazaki, 医学部, 教授 (50234620)

Co-Investigator(Renkei-kenkyūsha) KUNUGIDA Naoki  産業医科大学, 産業保健学部, 准教授 (90178020)
HIRANO Seisiro  独立行政法人国立環境研究所, 環境リスク研究センター, 室長 (20150162)
Project Period (FY) 2008 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2009: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2008: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Keywords産業中毒 / 自己抗体 / 鉱物油 / TCR / CD3ζ / SLE / T細胞レセプター / アルジニン / 炎症
Research Abstract

In our study, The serum arginine was decreased in mouse with peritoneal injection of pristane. The cause of this reduction is inflammation in peritoneal cavity. At the same time, CD3ζ of T-cell was decreased. We evaluated the metabolic system of CD3ζ to analyze the mechanism of CD3ζ reduction. We concluded that the mechanism of CD3ζ reduction is due to decline of mRNA of CD3ζ. But I have not known about the influence of arginine to CD3ζ reduction. We need more study to clear the relationship between CD3ζ reduction and decreased arginine.

Report

(4 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report
  • 2008 Annual Research Report
  • Research Products

    (5 results)

All 2011 2009 2008

All Journal Article (3 results) Presentation (2 results)

  • [Journal Article] 鉱物油の生態影響2011

    • Author(s)
      黒田嘉紀、山内武紀、竹内昌平
    • Journal Title

      産業医学レビュー 24(1)

      Pages: 1-11

    • NAID

      40018842501

    • Related Report
      2010 Final Research Report
  • [Journal Article] 鉱物油の生態影響2011

    • Author(s)
      黒田嘉紀, 他
    • Journal Title

      産業医学レビュー

      Volume: 24

    • NAID

      40018842501

    • Related Report
      2010 Annual Research Report
  • [Journal Article] 鉱物油の免疫学的影響2009

    • Author(s)
      黒田嘉紀、竹内昌平
    • Journal Title

      宮崎県医師会医学会誌 33(1)

      Pages: 1-6

    • Related Report
      2010 Final Research Report
  • [Presentation] ホルムアルデヒドの免疫学的影響2009

    • Author(s)
      黒田嘉紀, 他
    • Organizer
      日本産業衛生学会
    • Place of Presentation
      福岡
    • Year and Date
      2009-05-20
    • Related Report
      2010 Final Research Report
  • [Presentation] 鉱物油の危険性について(免疫学的観点から)2008

    • Author(s)
      黒田嘉紀, 他
    • Organizer
      産業衛生学会バイオマーカ研究会
    • Place of Presentation
      札幌
    • Year and Date
      2008-06-25
    • Related Report
      2010 Final Research Report

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Published: 2008-04-01   Modified: 2016-04-21  

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