Investigation on function and safety of non-nutrients in food

• Project/Area Number: 20590610
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Hygiene
• Research Institution: Suzuka University of Medical Science (2009-2011); Kyoto Prefectural University of Medicine (2008)
• Principal Investigator: SATOMI Yoshiko 鈴鹿医療科学大学, 薬学部, 教授 (90270678)
• Project Period (FY): 2008 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000); Fiscal Year 2011: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2010: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2009: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2008: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
• Keywords: カロテノイド / G1アレスト / GADD45 / MAPK / P450 / 抗腫瘍作用 / アポトーシス / GADD45A

Research Abstract

Fucoxanthin inhibited the growth of prostate cancer cells. Growth-inhibitory effects were accompanied by the induction of gadd45a and G1 arrest, and SAPK/JNK activation. Fucoxanthin inhibited the activities of CYP1A1/2 and CYP3A4, suggests that fucoxanthin may protect against pro-carcinogen toxicity.

Research Products

• [Journal Article] Inhibitory effect of halocynthiaxanthin on the growth of HepG2 cells (2012)
  • Author(s): Satomi Y
  • Journal Title: Carotenoid Sci Volume: 16(in press)
  • Peer Reviewed
• [Journal Article] Fucoxanthin induces Gadd45A expression and G_1 arrest with SAPK/JNK activation in LNCap human prostate cancer cells (2012)
  • Author(s): Satomi Y
  • Journal Title: Anticancer Res Volume: 32 Pages: 807-814
  • Peer Reviewed
• [Journal Article] Fucoxanthin induces Gadd45A expression and G_1 arrest with SAPK/JNK activation in LNCap human prostate cancer cells (2012)
  • Author(s): Satomi Yoshiko
  • Journal Title: Anticancer Research Volume: 32 Pages: 807-814
  • Peer Reviewed
• [Journal Article] Inhibitory effect of halocynthiaxanthin on the growth of HepG2 cells (2012)
  • Author(s): Satomi Yoshiko
  • Journal Title: Carotenoid Science Volume: 16(in press)
  • Peer Reviewed
• [Journal Article] Inhibitory effect of fucoxanthin and halocynthiaxanthin on CYP1A1 activity (2011)
  • Author(s): Satomi Y
  • Journal Title: Carotenoid Sci Volume: 15 Pages: 47-48
  • Peer Reviewed
• [Journal Article] Health promotion by antioxidants (2011)
  • Author(s): Nishino Hoyoku
  • Journal Title: Functional Foods in Health and Disease Volume: 12 Pages: 574-581
  • Peer Reviewed
• [Journal Article] Inhibitory effect of fucoxanthin and halocynthiaxanthin on CYP1A1 activity. (2011)
  • Author(s): Satomi Y
  • Journal Title: Carotenoid Sci. 15(in press.)
  • Peer Reviewed
• [Journal Article] Inhibitory effect of fucoxanthin and halocynthiaxanthin on CYP1A1 activity (2011)
  • Author(s): Satomi Yoshiko
  • Journal Title: Carotenoido Science Volume: 15(in press)
  • Peer Reviewed
• [Journal Article] Implication of mitogen-activated protein kinase in the induction of G1 cell cycle arrest and gadd45 expression by the carotenoid fucoxanthin in human cancer cells (2009)
  • Author(s): Satomi Y. and Nishino H
  • Journal Title: Biochimica et Biophysica Acta Volume: 1790 Pages: 260-266
  • Peer Reviewed
• [Journal Article] Implication of MAPKs in the anti-tumor effect of fucoxanthin depends on cell type. (2009)
  • Author(s): Satomi Y, Nishino H
  • Journal Title: Carotenoid Sci. 14 Pages: 43-45
  • Peer Reviewed
• [Journal Article] Implication of mitogen-activated protein kinase in the induction of G1 cell cycle arrest and gadd45 expression by the carotenoid fucoxanthin in human cancer cells. (2009)
  • Author(s): Satomi Y, Nishino H
  • Journal Title: Biochimica et Biophysica Acta 1790 Pages: 260-266
  • Peer Reviewed
• [Journal Article] Implication of MAPKs in the anti-tumor effect of fucoxanthin depends on cell type (2009)
  • Author(s): Satomi Yoshiko
  • Journal Title: Carotenoid Science 14 Pages: 43-45
  • Peer Reviewed
• [Journal Article] Implication of mitogen-activated protein kinase in the induction of G1 cell cycle arrest and gadd45 expression by the carotenoid fucoxanthin in human cancer cells. (2009)
  • Author(s): Satomi Yoshiko
  • Journal Title: Biochimica et Biophysica Acta (in press)
  • Peer Reviewed
• [Presentation] 海産カロテノイドであるフコキサンチンのCYP1A酵素活性抑制作用 (2012)
  • Author(s): 里見佳子
  • Organizer: 日本薬学会第132年会
  • Place of Presentation: 北海道大学
  • Year and Date: 2012-03-31
• [Presentation] 海産カロテノイドであるフコキサンチンのCYP1A1酵素活性抑制作用 (2011)
  • Author(s): 里見佳子
  • Organizer: 第84回日本生化学会大会
  • Place of Presentation: 京都
  • Year and Date: 2011-09-22
• [Presentation] 海産カロテノイドであるフコキサンチンのCYP1A酵素活性抑制作用 (2011)
  • Author(s): 里見佳子
  • Organizer: 第84回日本生化学会大会
  • Place of Presentation: 京都国際会館
  • Year and Date: 2011-09-22
• [Presentation] 海産カロテノイであるハロシンチアキサンチンのがん細胞増殖抑制作用 (2011)
  • Author(s): 里見佳子
  • Organizer: 日本薬学会第131年会
  • Place of Presentation: 静岡市(誌上発表)
  • Year and Date: 2011-03-30
• [Presentation] 海産カロテノイドであるハロシンチアキサンチンのがん細胞増殖抑制作用 (2011)
  • Author(s): 里見佳子
  • Organizer: 日本薬学会第131年会
  • Place of Presentation: ツインメッセ静岡(静岡市)(誌上発表)
  • Year and Date: 2011-03-30
• [Presentation] ハロシンチアキサンチンのがん細胞増殖抑制作用 (2010)
  • Author(s): 里見佳子
  • Organizer: 第24回カロテノイド研究談話会
  • Place of Presentation: 徳島
  • Year and Date: 2010-09-14
• [Presentation] ハロシンチアキサンチンのがん細胞増殖抑制作用 (2010)
  • Author(s): 里見佳子
  • Organizer: 第24回カロテノイド研究談話会
  • Place of Presentation: 徳島大学日亜メデイカルホール(徳島市)
  • Year and Date: 2010-09-14
• [Presentation] フコキサンチンにより発現が変動する遺伝子の網羅的解析 (2010)
  • Author(s): 里見佳子
  • Organizer: 日本薬学会第130年会
  • Place of Presentation: 岡山
  • Year and Date: 2010-03-30
• [Presentation] フコキサンチンにより発現が変動する遺伝子の網羅的解析 (2010)
  • Author(s): 里見佳子
  • Organizer: 日本薬学会第130年会
  • Place of Presentation: 岡山市
  • Year and Date: 2010-03-30
• [Presentation] フコキサンチンにより発現が変動する遺伝子の綱羅的解析 (2010)
  • Author(s): 里見佳子
  • Organizer: 日本薬学会第130年回
  • Place of Presentation: 岡山桃太郎アリーナ(岡山市)
  • Year and Date: 2010-03-30
• [Presentation] フコキサンチンはCYP1A1の発現を誘導するが、その酵素活性は抑制する (2009)
  • Author(s): 里見佳子
  • Organizer: 第68回日本癌学会学術総会
  • Place of Presentation: 横浜
  • Year and Date: 2009-10-03
• [Presentation] フコキサンチンはCYP1A1の発現を誘導するが、その酵素活性は抑制する (2009)
  • Author(s): 里見佳子
  • Organizer: 第68回日本癌学会学術総会
  • Place of Presentation: パシフィコ横浜(横浜市)
  • Year and Date: 2009-10-03
• [Presentation] フコキサンチンはCYP1A1の発現を誘導するが、その酵素活性は抑制する (2009)
  • Author(s): 里見佳子
  • Organizer: 第23回カロテノイド研究談話会
  • Place of Presentation: 仙台市
  • Year and Date: 2009-09-16
• [Presentation] フコキサンチンはCYP1A1の発現を誘導するが、その酵素活性は抑制する (2009)
  • Author(s): 里見佳子
  • Organizer: 第23回カロテノイド研究談話会
  • Place of Presentation: 東北大学百周年記念会館川内萩ホール(仙台市)
  • Year and Date: 2009-09-16
• [Presentation] フコキサンチンによるGADD45A誘導機序;細胞種による違いについて (2008)
  • Author(s): 里見佳子
  • Organizer: 第67回日本癌学会学術総会
  • Place of Presentation: 名古屋
  • Year and Date: 2008-10-28
• [Presentation] フコキサンチンによるGADD45A誘導機序;細胞種による違いについて (2008)
  • Author(s): 里見佳子
  • Organizer: 第67回日本癌学会学術総会
  • Place of Presentation: 名古屋市
  • Year and Date: 2008-10-28
• [Presentation] p38 MAPK pathway is implicated in the induction of GADD45A and G1 arrest by fucoxanthin in HepG2 cells but not in DU145 cells. (2008)
  • Author(s): Satomi Y.
  • Organizer: The 15^<th> International Symposium on Carotenoids
  • Place of Presentation: 沖縄県恩納村
  • Year and Date: 2008-06-22
• [Presentation] P38 MAPK pathway is implicated in the induction of GADD45A and G1 arrest by fucoxanthin in HepG2 cells butnot in DU145 cells. (2008)
  • Author(s): Satomi Yoshiko
  • Organizer: The 15^<th> International Symposium on Carotenoids
  • Place of Presentation: 沖縄県恩納村
• [Presentation] フコキサンチンの抗腫瘍作用におけるP38MAPKの関与 ; 細胞種による違いについて (2008)
  • Author(s): 里見 佳子
  • Organizer: 第22回ヵロテノイド研究談話会
  • Place of Presentation: 沖縄県恩納村
• [Presentation] フコキサンチンによるGADD45A誘導機序 ; 細胞種による違いについて (2008)
  • Author(s): 里見 佳子
  • Organizer: 第67回日本癌学会学術総会
  • Place of Presentation: 名古屋市
• [Book] 腫瘍薬学 (2010)
  • Author(s): 川西正祐、中瀬一則、大井一弥編, 有馬公伸、里見佳子, 他53名
  • Publisher: 南山堂