| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2010: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2009: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2008: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Research Abstract |
The CDAA diet induced NASH in Fisher rats, characerized by steatois, ilammation, fibrosis, and cirrosis in the liver. Serum level of endotoxin in the portal vein and lipoperoxidation in the liver were observe at 2 month of CDAA diet. On the contrary, treatment of rats with Clostridium butyricum in CDAA diet markedly improved liver fibrosis and lowered the level of endotoxin and GST-P. Alteration of the intestinal flora and butyrate produced by Clostridium butyricum may involve in these protective response to the NASH progression.
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