Elucidation of the development mechanism of the alcohol and aceta l dehyde-induced squamous-cell-carcinoma by using A/dh2 deficient mice.
Project/Area Number |
20590620
|
Research Category |
Grant-in-Aid for Scientific Research (C)
|
Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Hygiene
|
Research Institution | University of Occupational and Environmental Health, Japan |
Principal Investigator |
OZAKI Shinichi 産業医科大学, 医学部, 非常勤助教 (70412632)
|
Co-Investigator(Kenkyū-buntansha) |
OYAMA Tsunehiro 兵庫医科大学, 医学部, 非常勤講師 (00309965)
KAWAMOTO Toshihiro 産業医科大学, 医学部, 教授 (60177748)
GOTOH Akinobu 兵庫医科大学, 医学部, 教授 (70283885)
ISSE Toyohi 産業医科大学, 医学部, 准教授 (80341494)
|
Project Period (FY) |
2008 – 2012
|
Project Status |
Completed (Fiscal Year 2012)
|
Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2012: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2011: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2010: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2009: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2008: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
|
Keywords | 環境中毒 / Aldh2欠損マウス / 癌 / アルコール / 皮膚癌 / 扁平上皮癌 |
Research Abstract |
The outer skin can be observed simply. Therefore we administered acetaldehyde to the Aldh2-deficient mice subcutaneously. Squamous cell carcinomas occurred on the back skins of the Aldh2--deficient mice and we examined them molecular biologically and pathologically. It is well known that the Aldh2-deficient individuals should have greater risks of the incidence of the oropharyngeal or the esophageal cancer by drinking. We apply this result to the medical treatment and the prevention of cancers.
|
Report
(7 results)
Research Products
(38 results)
-
[Journal Article] Cytochrome P450 in non-small cell lung cancer related to exogenous chemical metabolism2012
Author(s)
Oyama T, Uramoto H, Kagawa N, Yoshimatsu T, Osaki T, Nakanishi R, Nagaya H, Kaneko K, Muto M, KawamotoT, Tanaka F, Gotoh A
-
Journal Title
Front Biosci
Volume: S4
Pages: 1539-1546
Related Report
Peer Reviewed
-
-
-
-
-
-
-
[Journal Article] Effects of acetaldehyde inhalation in mitochondrial aldehyde dehydrogenase deficient mice (Aldh2^<-/->)2010
Author(s)
Oyama T, Nagayoshi H, Matsuda T, Oka M, Isse T, Yu HS, Pham TTP, Tanaka M, Kagawa N, Kaneko K, Kawamoto T
-
Journal Title
Front Biosci (Elite Ed)
Volume: 2
Pages: 1344-1354
Related Report
Peer Reviewed
-
[Journal Article] Effects of acetaldehyde inhalation in mitochondrial aldehyde dehydrogenase deficient mice (Aldh2^<-/->).2010
Author(s)
Oyama T, Nagayoshi H, Matsuda T, Oka M, Isse T, Yu HS, Pham TTP, Tanaka M, Kagawa N, Kaneko K, Kawamoto T
-
Journal Title
Front Biosci (Elite Ed) 2
Pages: 1344-1354
Related Report
Peer Reviewed
-
[Journal Article] EGFR gene alterations as a prognostic biomarker in advanced esophageal squamous cell carcinoma.2010
Author(s)
Kaneko K, Kumekawa Y, Makino R, Nozawa H, Hirayama Y, Kogo M, Konishi K, Katagiri A, Kubota Y, Muramoto T, Kushima M, Ohmori T, Oyama T, Kagawa N, Ohtsu A, Imawari M
-
Journal Title
Front Biosci 15
Pages: 65-72
Related Report
Peer Reviewed
-
-
-
-
-
-
-
-
-
-
-
-
[Journal Article] Expression of Cytochrome P450 in non-small cell lung cancer2008
Author(s)
Oyama T, Sugio K, Isse T, Matsumoto A, Nose N, Uramoto H, Nozoe T, Morita M, Kagawa N, Osaki T, Muto M, Yasumoto K, Kawamoto T
-
Journal Title
Front Biosci
Volume: 13
Pages: 5787-5793
Related Report
Peer Reviewed
-
[Journal Article] Expression of Cytochrome P450 in non-small cell lung cancer.2008
Author(s)
Oyama T, Sugio K, Isse T, Matsumoto A, Nose N, Uramoto H, Nozoe T, Morita M, Kagawa N, Osaki T, Muto M, Yasumoto K, Kawamoto T
-
Journal Title
Front Biosci 13
Pages: 5787-5793
Related Report
Peer Reviewed
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-