Impaired glucose tolerance and the risk of neoplasm : results froma large-scale population-based cohort study in Funagata study

• Project/Area Number: 20590633
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Public health/Health science
• Research Institution: Yamagata University
• Principal Investigator: OIZUMI Toshihide Yamagata University, 大学院・医学系研究科, 助教 (00344797)
• Project Period (FY): 2008 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000); Fiscal Year 2010: ¥390,000 (Direct Cost: ¥300,000、Indirect Cost: ¥90,000); Fiscal Year 2009: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2008: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
• Keywords: 疫学 / 耐糖能障害 / 悪性新生物

Research Abstract

We prospectively examined the association between status of glucose tolerance and subsequent risk of cancer in the center-based retrospective study. A total of 3984 general Japanese persons (1779 men and 2205 women) aged over 35 years in Funagata town. A total of 414 cases of newly diagnosed cancer were identified. We observed a increased risk of total cancer with DM compared with normal glucose tolerance group(p=0.0489 Logrank). Patients with DM drawn from the general Japanese population may be at increased risk of total cancer.

Research Products

• [Journal Article] Association of the clusterin gene polymorphisms with type 2 diabetes mellitus. (2010)
  • Author(s): Daimon M., Oizumi T., 他
  • Journal Title: Metabolism (Epub ahead of print)
  • Peer Reviewed
• [Journal Article] Hemoglobin A1c in predicting progression to diabetes. (2010)
  • Author(s): Nakagami T. Tajima N, Oizumi T, 他
  • Journal Title: Diabetes Research and Clinical Practice 87 Pages: 126-13
  • Peer Reviewed
• [Journal Article] Association of the clusterin gene polymorphisms with type 2 diabetes mellitus. (2010)
  • Author(s): Daimon M
  • Journal Title: Metabolism Volume: (Epub ahead of print)
  • Peer Reviewed
• [Journal Article] 糖尿病大血管障害-舟形研究 (2010)
  • Author(s): 大門真
  • Journal Title: 日本臨床 Volume: 68 Pages: 843-6
• [Journal Article] Hemoglobin A1c in predicting progression to diabetes. (2010)
  • Author(s): Nakagami T, et al.
  • Journal Title: Diabetes Research and Clinical Practice 87 Pages: 126-131
  • Peer Reviewed
• [Journal Article] Association of the Ser326Cys polymorphism in the OGG1 gene with type 2 DM. (2009)
  • Author(s): Daimon M., Oizumi T., 他
  • Journal Title: Biochemical and Biophysical Research Communications 369 Pages: 26-29
  • Peer Reviewed
• [Journal Article] Association of the Ser326Cys polymorphism in the OGG1 gene with type 2 DM. (2009)
  • Author(s): Daimon M, et al.
  • Journal Title: Biochemical and Biophysical Research Communications 386 Pages: 26-29
  • Peer Reviewed
• [Journal Article] A functional polymorphism of the TNF-α gene that is associated with type 2 DM (2009)
  • Author(s): Susa Shinji, et al.
  • Journal Title: Biochemical and Biophysical Research Communications 369 Pages: 943-947
  • Peer Reviewed
• [Journal Article] Impaired glucose tolerance is a risk factor for stroke in a Japanese sample--the Funagata study. (2008)
  • Author(s): Oizumi T., 他
  • Journal Title: Metabolism : clinical and experimental 57 Pages: 333-338
  • Peer Reviewed
• [Journal Article] Impaired glucose tolerance is a risk factor for stroke in a Japanese sample--the Funagata study (2008)
  • Author(s): Oizumi T, et.al.
  • Journal Title: Metabolism : clinical and experimental 57 Pages: 333-338
  • Peer Reviewed
• [Presentation] 糖尿病検診者における耐糖能と脂肪酸分画測定値の関係と諸相 (2010)
  • Author(s): 大泉俊英, 他
  • Organizer: 第53回日本糖尿病学会年次学術集会
  • Place of Presentation: 岡山市
  • Year and Date: 2010-05-28
• [Presentation] 糖尿病検診者における耐糖:能と脂肪酸分画測定値の関係と諸相 (2010)
  • Author(s): 大泉俊英
  • Organizer: 第53回日本糖尿病学会年次学術集会
  • Place of Presentation: 岡山市
  • Year and Date: 2010-05-28
• [Presentation] 当院糖尿病外来における治療実態と血糖コントロールについて (2009)
  • Author(s): 尾上沙璃、大泉俊英, 他
  • Organizer: 第52回日本糖尿病学会年次学術集会
  • Place of Presentation: 日大阪市
  • Year and Date: 2009-05-21
• [Presentation] 当院糖尿病外来における治療実態と血糖コントロールについて (2009)
  • Author(s): 尾上沙璃, 他
  • Organizer: 第52回日本糖尿病学会年次学術集会
  • Place of Presentation: 大阪
  • Year and Date: 2009-05-21
• [Presentation] 山形県舟形町における糖尿病有病率および耐糖能とヘモグロビンA1cの診断能の関係と諸相 (2008)
  • Author(s): 大泉俊英, 他
  • Organizer: 第51回日本糖尿病学会年次学術集会
  • Place of Presentation: 日東京都
  • Year and Date: 2008-05-23
• [Presentation] 地域住民糖尿病検診における血清I型コラーゲン架橋Nテロペプチド測定値とその諸相(山形県舟形町糖尿病検診より) (2008)
  • Author(s): 大泉俊英, 他
  • Organizer: 第81回日本内分泌学会学術総会
  • Place of Presentation: 青森市
  • Year and Date: 2008-05-17
• [Presentation] 地域住民糖尿病検診における血清I型コラーゲン架橋Nテロペプチド測定値とその諸相(由形県舟形町糖尿病検診より) (2008)
  • Author(s): 大泉俊英, 他
  • Organizer: 第81回日本内分泌学会学術総会
  • Place of Presentation: 青森
• [Presentation] 山形県舟形町における糖尿病有病率および耐糖能とヘモグロビンAlcの診断能の関係と諸相 (2008)
  • Author(s): 大泉俊英, 他
  • Organizer: 第51回日本糖尿病学会年次学術集会
  • Place of Presentation: 東京
• [Remarks] ホームページ等