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The significance of oxidative stress-related markers in health education classes for lifestyle diseases

Research Project

Project/Area Number 20590645
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Public health/Health science
Research InstitutionJichi Medical University

Principal Investigator

KOTANI Kazuhiko  Jichi Medical University, 医学部, 講師 (60335510)

Project Period (FY) 2008 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2009: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2008: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Keywords健康科学 / 健康教育 / 肥満 / 酸化ストレス / 代謝 / 酸化ストレスマーカー / 酸化LDL
Research Abstract

A weight reduction education on individuals with metabolic syndrome or a smoking cessation intervention on smokers suggested that the diacron reactive oxygen metabolites, an oxidative status marker, could reflect the upstream pathophysiology of the development of metabolic syndrome-related complications or smoking-induced disorders. Several intervention studies indicated that the oxidized low-density lipoprotein-related markers could provide more sensitive and comprehensive information regarding the association between lifestyles and atherogenic conditions when compared to general lipids markers. These measurements may lead to an open field for further investigation to improve health education classes for lifestyle diseases.

Report

(4 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report
  • 2008 Annual Research Report
  • Research Products

    (41 results)

All 2011 2010 2009 2008 Other

All Journal Article (26 results) (of which Peer Reviewed: 26 results) Presentation (14 results) Remarks (1 results)

  • [Journal Article] The association between circulating secreted protein acidic and rich in cysteine (SPARC) and glycosylated haemoglobin during lifestyle-modified weight reduction intervention in obese male subjects.2011

    • Author(s)
      Kotani K, Yamada T, Taniguchi N.
    • Journal Title

      J Int Med Res. 39(2)

      Pages: 528-532

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] The relationship between urinary 8-hydroxydeoxyguanosine and metabolic risk factors in asymptomatic subjects.2011

    • Author(s)
      Miyamoto M, Kotani K, Ishibashi S, Taniguchi N.
    • Journal Title

      Med Princ Pract. 20(2)

      Pages: 187-190

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] The potential of serum amyloid A-LDL as a novel biomarker for cardiovascular disease risk.2010

    • Author(s)
      Kotani K, Satoh N, Yamada T, Gugliucci A.
    • Journal Title

      Clin Lipid. 5(4)

      Pages: 489-495

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] The association between adiponectin, HDL-cholesterol and α1-antitrypsin-LDL in female subjects without metabolic syndrome.2010

    • Author(s)
      Kotani K, Yamada T, Taniguchi N.
    • Journal Title

      Lipids Health Dis. 9(1)

      Pages: 147-147

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] The relationship between serum C-reactive protein and daily physical activity in Japanese hypertensive patients.2010

    • Author(s)
      Uurtuya S, Kotani K, Koibuchi H, Miyamoto M, Kario K, Yamada T, Taniguchi N.
    • Journal Title

      Clin Exp Hypertens. 32(8)

      Pages: 517-522

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] The influence of metabolic syndrome and chronic kidney disease on hemorheology assessed by the microchannel method.2010

    • Author(s)
      Kotani K, Satoh N, Yamada K, Taniguchi N, Shimatsu A.
    • Journal Title

      J Physiol Anthropol. 29(5)

      Pages: 157-160

    • NAID

      10026670240

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Relationship between reactive oxygen metabolites and carotid intima-media thickness in subjects with hypercholesterolemia.2010

    • Author(s)
      Kotani K, Koibuchi H, Miyamoto M, Yamada T, Taniguchi N.
    • Journal Title

      Med Princ Pract. 19(6)

      Pages: 496-498

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] The association between blood glucose and oxidized lipoprotein(a) in healthy young women.2010

    • Author(s)
      Kotani K, Yamada S, Uurtuya S, Yamada T, Taniguchi N, Sakurabayashi I.
    • Journal Title

      Lipids Health Dis. 9

      Pages: 103-103

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Serum aspirin esterase is strongly associated with glucose and lipids in healthy subjects : different association patterns in subjects with type 2 diabetes mellitus.2010

    • Author(s)
      Kotani K, Kimura S, Ebara T, Caccavello R, Gugliucci A.
    • Journal Title

      Diabetol Metab Syndr. 2

      Pages: 50-50

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Serum cholesterol concentration associated with aspirin esterase activity in older people : preliminary data.2010

    • Author(s)
      Kotani K, Caccavello R, Hermo R, Yamada T, Taniguchi N, Gugliucci A.
    • Journal Title

      Int J Med Sci. 7(2)

      Pages: 90-93

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] The association between resistin, high-density lipoprotein cholesterol and carotid atherosclerosis in elderly women with hypertension.2010

    • Author(s)
      Kotani K, Adachi S, Tsuzaki K, Sakane N, Gugliucci A.
    • Journal Title

      Int J Cardiol. 141(2)

      Pages: 193-194

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] The association between adiponectin, HDL-cholesterol and α 1-antitrypsin-LDL in female subjects without metabolic syndrome2010

    • Author(s)
      Kotani K, et al
    • Journal Title

      Lipids Health Dis

      Volume: 9(電子版) Pages: 147-147

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The influence of metabolic syndrome and chronic kidney disease on hemorheology assessed by the microchannel method2010

    • Author(s)
      Kotani K, et al
    • Journal Title

      J Physiol Anthropol

      Volume: 29 Pages: 157-160

    • NAID

      10026670240

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Relationship between reactive oxygen metabolites and carotid intima-media thickness in subjects with hypercholesterolemia2010

    • Author(s)
      Kotani K, et al
    • Journal Title

      Med Princ Pract

      Volume: 19 Pages: 496-498

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The association between blood glucose and oxidized lipoprotein(a) in healthy young women2010

    • Author(s)
      Kotani K, et al
    • Journal Title

      Lipids Health Dis

      Volume: 9(電子版) Pages: 103-103

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Serum aspirin esterase is strongly associated with glucose and lipids in healthy subjects : different association patterns in subjects with type 2 diabetes mellitus2010

    • Author(s)
      Kotani K, et al
    • Journal Title

      Diabetol Metab Syndr

      Volume: 2(電子版) Pages: 50-50

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Serum cholesterol concentration associated with aspirinesterase activity in older people : preliminary data2010

    • Author(s)
      Kotani K, et al
    • Journal Title

      Int J Med Res

      Volume: 7 Pages: 90-93

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Changes on the physiological lactonase activity of serum paraoxonase 1 by a diet intervention for weight loss in healthy overweight and obese women.2009

    • Author(s)
      Kotani K, Sakane N, Sano Y, Tsuzaki K, Matsuoka Y, Egawa K, Yoshimura M, Horikawa C, Kitagawa Y, Kiso Y, Kimura S, Schulze J, Taing J, Gugliucci A.
    • Journal Title

      J Clin Biochem Nutr. 45(3)

      Pages: 329-334

    • NAID

      130004879181

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Adiponectin gene single-nucleotide polymorphisms and treatment response to obesity.2009

    • Author(s)
      Tsuzaki K, Kotani K, Nagai N, Saiga K, Sano Y, Hamada T, Moritani T, Yoshimura M, Egawa K, Horikawa C, Kitagawa Y, Kiso Y, Sakane N.
    • Journal Title

      J Endocrinol Invest. 32(5)

      Pages: 395-400

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] The effects of lifestyle modification on a new oxidized low-density lipoprotein marker, serum amyloid A-LDL, in subjects with primary lipid disorder.2009

    • Author(s)
      Kotani K, Koibuchi H, Yamada T, Taniguchi N.
    • Journal Title

      Clin Chim Acta. 409(1-2)

      Pages: 67-69

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Serum amyloid A protein and carotid intima-media thickness in healthy young subjects.2009

    • Author(s)
      Uurtuya S, Kotani K, Koibuchi H, Taniguchi N, Yamada T.
    • Journal Title

      J Atheroscler Thromb. 16(3)

      Pages: 299-300

    • NAID

      10025765890

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Short-term low calorie diet intervention reduces serum advanced glycation end products in healthy overweight or obese adults.2009

    • Author(s)
      Gugliucci A, Kotani K, Taing J, Matsuoka Y, Sano Y, Yoshimura M, Egawa K, Horikawa C, Kitagawa Y, Kiso Y, Kimura S, Sakane N.
    • Journal Title

      Ann Nutr Metab. 54(3)

      Pages: 197-201

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Thermoregulatory sympathetic nervous system activity and diet-induced waist-circumference reduction in obese Japanese women.2009

    • Author(s)
      Fujibayashi M, Hamada T, Matsumoto T, Kiyohara N, Tanaka S, Kotani K, Egawa K, Kitagawa Y, Kiso Y, Sakane N, Moritani T.
    • Journal Title

      Am J Hum Biol. 21(6)

      Pages: 828-835

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] A novel oxidized low-density lipoprotein marker, serum amyloid A-LDL, is associated with obesity and the metabolic syndrome.2009

    • Author(s)
      Kotani K, Satoh N, Kato Y, Araki R, Koyama K, Okajima T, Tanabe M, Oishi M, Yamakage H, Yamada K, Hattori M, Shimatsu A.
    • Journal Title

      Atherosclerosis. 204(2)

      Pages: 526-531

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Changes on the physiological lactonase activity of serum paraoxonase 1 by a diet intervention for weight loss in healthy overweight and obese women2009

    • Author(s)
      Kotani K, et al
    • Journal Title

      J Clin Biochem Nutr 45

      Pages: 329-334

    • NAID

      130004879181

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The effects of lifestyle modification on a new oxidized low-density lipoprotein marker, serum amyloid A-LDL, in subjects with primary lipid disorder2009

    • Author(s)
      Kotani K, et al
    • Journal Title

      Clin Chim Acta 409

      Pages: 67-69

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Presentation] The effects of lifestyle modification treatment on the serumoxidized lipoprotein (a) levels in obese women : a comparison with native lipoprotein (a)2010

    • Author(s)
      Kotani K, et al
    • Organizer
      2010 Annual meeting of the American Association for Clinical Chemistry
    • Place of Presentation
      Anaheim
    • Year and Date
      2010-07-28
    • Related Report
      2010 Annual Research Report
  • [Presentation] The effects of lifestyle modification treatment on the serum oxidized lipoprotein(a) levels in obese women : a comparison with native lipoprotein(a).2010

    • Author(s)
      Kotani K, Yamada S, Yamada T, Taniguchi N, Sakurabayashi I
    • Organizer
      2010 Annual meeting of the American Association for Clinical Chemistry.
    • Place of Presentation
      Anaheim, USA
    • Related Report
      2010 Final Research Report
  • [Presentation] Effect of lifestyle modifications on a new oxidized low-density lipoprotein marker, serum amyloid A-LDL, in asymptomatic subjects with primary dyslipidemia2009

    • Author(s)
      小谷和彦, ほか
    • Organizer
      2009 Annual meeting of the American Association for Clinical Chemistry
    • Place of Presentation
      Chicago
    • Year and Date
      2009-07-21
    • Related Report
      2009 Annual Research Report
  • [Presentation] 糖尿病合併脂質異常症患者におけるsdLDLの血糖管理の影響2009

    • Author(s)
      津崎こころ, 小谷和彦, ほか
    • Organizer
      第52回日本糖尿病学会年次学術集会
    • Place of Presentation
      大阪
    • Year and Date
      2009-05-23
    • Related Report
      2009 Annual Research Report
  • [Presentation] 脂質異常症に対する栄養指導の酸化ストレス低減に及ぼす影響:PON1遺伝子多型との関連2009

    • Author(s)
      松岡幸代, 小谷和彦, ほか
    • Organizer
      第52回日本糖尿病学会年次学術集会
    • Place of Presentation
      大阪
    • Year and Date
      2009-05-21
    • Related Report
      2009 Annual Research Report
  • [Presentation] Gene-diet interaction between nutritional counseling and oxidative stress in hyperlipidemic subjects2009

    • Author(s)
      松岡幸代, 小谷和彦, ほか
    • Organizer
      17^<th> European Congress on Obesity
    • Place of Presentation
      Amsterdam
    • Year and Date
      2009-05-07
    • Related Report
      2009 Annual Research Report
  • [Presentation] Effect of lifestyle modifications on a new oxidized low-density lipoprotein marker, serum amyloid A-LDL, in asymptomatic subjects with primary dyslipidemia.2009

    • Author(s)
      Kotani K, Yamada T, Taniguchi N, Kawano M, Sakurabayashi I
    • Organizer
      2009 Annual meeting of the American Association for Clinical Chemistry (AACC).
    • Place of Presentation
      Chicago, USA
    • Related Report
      2010 Final Research Report
  • [Presentation] 一般住民に対する運動および食事介入前後の体重,腹囲,BMI,体脂肪率の変化2009

    • Author(s)
      上原里程, 山縣千開, 福原円, 定金敦子, 青山泰子, 小谷和彦, 高村寿子, 中村好一
    • Organizer
      第68回日本公衆衛生学会総会
    • Place of Presentation
      奈良
    • Related Report
      2010 Final Research Report
  • [Presentation] 地域の健康教室における脂質に特化した検査の有用性と今後の課題2009

    • Author(s)
      津崎こころ, 小谷和彦, 山田俊幸
    • Organizer
      第60回日本電気泳動学会総会
    • Place of Presentation
      長野
    • Related Report
      2010 Final Research Report 2009 Annual Research Report
  • [Presentation] 肥満に対する健康教室の経験2009

    • Author(s)
      懸樋英一, 小谷和彦
    • Organizer
      第32回日本プライマリ・ケア学会学術会議
    • Place of Presentation
      京都
    • Related Report
      2010 Final Research Report 2009 Annual Research Report
  • [Presentation] LDL粒子サイズからみた動脈硬化性疾患予防ガイドラインの検討.2008

    • Author(s)
      津崎こころ, 小谷和彦, ほか.
    • Organizer
      第52回日本電気泳動学会総会
    • Place of Presentation
      東京
    • Year and Date
      2008-11-15
    • Related Report
      2008 Annual Research Report
  • [Presentation] 肥満症におけるEPAによる新規酸化LDL・SAA-LDLの改善を介した抗動脈硬化作用.2008

    • Author(s)
      山陰一, 小谷和彦, ほか.
    • Organizer
      第29回日本肥満学会総会
    • Place of Presentation
      大分
    • Year and Date
      2008-10-17
    • Related Report
      2008 Annual Research Report
  • [Presentation] 運動による脂質プロファイルへの効果.2008

    • Author(s)
      津崎こころ, 小谷和彦, ほか.
    • Organizer
      第48回臨床化学年次学術集会
    • Place of Presentation
      浜松
    • Year and Date
      2008-08-29
    • Related Report
      2008 Annual Research Report
  • [Presentation] 生活習慣病における酸化分子の測定とその意義.2008

    • Author(s)
      小谷和彦, ほか.
    • Organizer
      第39回日本比較臨床医学会学術集会
    • Place of Presentation
      東京
    • Year and Date
      2008-07-06
    • Related Report
      2008 Annual Research Report
  • [Remarks] ホームページ等なし

    • Related Report
      2010 Final Research Report

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Published: 2008-04-01   Modified: 2016-04-21  

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