Epidemiological study on the association between the autonomic function and glucose intolerance

• Project/Area Number: 20590647
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Public health/Health science
• Research Institution: Ehime University
• Principal Investigator: SAITO Isao Ehime University, 大学院・医学系研究科, 准教授 (90253781)
• Co-Investigator(Kenkyū-buntansha): NAITO Yoshihiko 武庫川女子大学, 生活環境部, 教授 (90388801) ; MORIWAKI Chinatsu 中村学園大学, 短期大学部, 准教授 (90280289) ; TANIGAWA Takeshi 愛媛大学, 大学院・医学系研究科, 教授 (80227214) ; SAKURAI Susumu 愛媛大学, 大学院・医学系研究科, 講師 (50375515) ; 原田 亜紀子 千葉県衛生研究所, 健康疫学室, 研究員 (00451774)
• Project Period (FY): 2008 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000); Fiscal Year 2010: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2009: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2008: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
• Keywords: 地域保健 / 自律神経系機能 / 耐糖能異常 / 疫学研究 / 循環器疾患 / 心拍変動 / 予防医学 / 疫学

Research Abstract

Aim of study was to examine the association between the autonomic function and glucose tolerance in Japanese. 1032 individuals who were free of treated diabetes were studied. Indices representing the autonomic function were examined based on the R-R intervals during 5 min, and 75g oral glucose tolerance test was done for them. High levels of the standard deviation of all normal R-R intervals (SDDN) and heart rate variability (HRV) index were significantly associated with decreased odds ratios for IGT or diabetes. The significant associations were remained after adjustment of BMI, diastolic blood pressure, a use of antihypertensive agents, physical activity, smoking, and alcohol drinking. Our data suggest that autonomic nervous system may influence the glucose intolerance and diabetes among the general Japanese population.

Research Products

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