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Risk assessment based on the clinical characteristics of leukemia and the related disorders in atomic bomb survivors

Research Project

Project/Area Number 20590649
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Public health/Health science
Research InstitutionNagasaki University

Principal Investigator

IWANAGA Masako  Nagasaki University, 健康生活学部, 教授 (00372772)

Co-Investigator(Kenkyū-buntansha) 宮崎 泰司  長崎大学, 大学院・医歯薬学総合研究科, 教授 (40304943)
朝長 万左男  長崎大学, 大学院・医歯薬学総合研究科, 教授 (40100854)
Co-Investigator(Renkei-kenkyūsha) MIYAZAKI Yasushi  長崎大学, 院医歯薬学総合研究科, 教授 (40304943)
TOMONAGA Masao  長崎大学, 院医歯薬学総合研究科, 教授 (40100854)
Research Collaborator 早田 みどり  長崎県腫瘍登録室, 室長
HSU Wan-Ling  放射線影響研究所統計部, 博士
三根 真理子  長崎大学, 医学部・原研情報室, 准教授、他
松尾 辰樹  長崎市原爆被爆者健康管理センター, センター長、他
高崎 由美  日赤長崎原爆病院, 血液内科, 医師、他
山村 政臣  長崎市民病院, 血液内科, 医師、他
木場 隆司  長崎市成人病センター, 血液内科, 医師、他
吉田 善春  聖フランシスコ病院, 血液内科, 医師、他
波多 智子  長崎大学病院, 血液内科, 医師、他
山田 恭暉  長崎大学病院, 臨床検査学講座, 准教授
PRESTON Dale L.  米国 Hirosoft International, 社博士
Project Period (FY) 2008 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2009: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2008: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywordsがん疫学 / 白血病 / 骨髄異形成症候群 / 原爆被爆者集団 / 放射線誘発白血病 / がん疫学研究 / 腫瘍登録 / 放射線被爆 / 造血器腫瘍分類 / リスク評価
Research Abstract

We conducted a retrospective cohort study by using two databases of Nagasaki atomic bomb survivors, Nagasaki University Atomic-Bomb Disease Institute and RERF. Patients with MDS diagnosed from 1985-2004 were identified by record linkage between the cohorts and the Nagasaki Prefecture Cancer Registry. MDS rate increased inversely with exposure distance, and showed a significant linear response to exposure dose level with an ERR 4.3/Gy. The MDS risk was significantly greater in those exposed when young. A significant linear radiation dose-response for MDS exists in atomic bomb survivors 40-60 years after radiation exposure.

Report

(4 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report
  • 2008 Annual Research Report
  • Research Products

    (34 results)

All 2011 2010 2009 2008

All Journal Article (19 results) (of which Peer Reviewed: 7 results) Presentation (10 results) Book (5 results)

  • [Journal Article] Risk of Myelodysplastic Syndromes in People Exposed to Ionizing Radiation : a Retrospective Cohort Study of Nagasaki Atomic Bomb Survivors.2011

    • Author(s)
      Iwanaga M, Hsu WL, Soda M, 他, Miyazaki Y, 他, Tomonaga M
    • Journal Title

      J Clin Oncol. 29(4)

      Pages: 428-34

    • Related Report
      2010 Final Research Report
  • [Journal Article] Risk of Myelodysplastic Syndromes in People Exposed to lonizing Radiation : a Retrospective Cohort Study of Nagasaki Atomic Bomb Survivors.2011

    • Author(s)
      Iwanaga M, et al
    • Journal Title

      Journal of Clinical Oncology

      Volume: 29(4) Pages: 428-434

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 長崎原爆被爆者における多発性骨髄腫検診(第7報)MGUSの予後調査2010

    • Author(s)
      土屋健史, 岩永正子, ほか
    • Journal Title

      長崎医学会雑誌

      Volume: 85(特集号) Pages: 124-129

    • Related Report
      2010 Annual Research Report
  • [Journal Article] Differences in the distribution of subtypes according to the WHO classification 2008 between Japanese and German patients with Refractory Anemia according to the FAB classification in Myelodysplastic Syndromes.2010

    • Author(s)
      Matsuda A, et al
    • Journal Title

      Leukemia Research (印刷中)

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Trends in HTLV-1 prevalence and the incidence of adult Tcell leukemia/lymphoma (ATLL) in Nagasaki, Japan.2010

    • Author(s)
      Koga Y, Iwanaga M, et al
    • Journal Title

      Journal of Medical Virology 82(4)

      Pages: 668-674

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Relationship Between Monoclonal Gammopathy of Undetermined Significance and Radiation Exposure in Nagasaki Atomic Bomb Survivors.2009

    • Author(s)
      Iwanaga M, 他, Miyazaki Y, 他, Tomonaga M
    • Journal Title

      Blood 113(8)

      Pages: 1639-1650

    • NAID

      120006982803

    • Related Report
      2010 Final Research Report
  • [Journal Article] 話題:長崎原爆とMGUS2009

    • Author(s)
      岩永正子
    • Journal Title

      血液・腫瘍科(科学評論社) 59(1)

      Pages: 64-72

    • Related Report
      2010 Final Research Report
  • [Journal Article] 【話題】長崎における被爆とMGUS2009

    • Author(s)
      岩永正子
    • Journal Title

      血液・腫瘍科(医学評論社) 59(1)

      Pages: 64-72

    • Related Report
      2009 Annual Research Report
  • [Journal Article] 【特集:MDS診療の最近の進歩】第IV版WHO分類によるMDSの分類と診断2009

    • Author(s)
      宮崎泰司
    • Journal Title

      血液・腫瘍科(医学評論社) 59(1)

      Pages: 13-19

    • Related Report
      2009 Annual Research Report
  • [Journal Article] Relationship Between Monoclonal Gammopathy of Undetermined Significance and Radiation Exposure in Nagasaki Atomic Bomb Survivors.2009

    • Author(s)
      Iwanaga M, et.al
    • Journal Title

      Blood 113(8)

      Pages: 1639-1650

    • NAID

      120006982803

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article]2009

    • Author(s)
      岩永正子, 他
    • Journal Title

      がん対策基本法施行後の現状と課題/JACR MONOGRAPH NO.14,:全国地域がん登録を用いた原発性マクログロブリン血症の羅患率(地域がん登録全国協会,東京)

      Pages: 72-73

    • Related Report
      2009 Annual Research Report
  • [Journal Article]2009

    • Author(s)
      宮崎泰司
    • Journal Title

      2010-2011 EBM血液疾患の治療。【I.赤血球の疾患】9.WHO分類第4版による骨髄異形成症候群(MDS)の診断(金倉譲,木崎昌弘,鈴木律朗,神田善伸(編))(中外医学社,東京)

      Pages: 45-49

    • Related Report
      2009 Annual Research Report
  • [Journal Article]2009

    • Author(s)
      宮崎泰司
    • Journal Title

      WHO分類第4版による白血病・リンパ系腫瘍の病態学。【6.急性骨髄性白血病および関連前駆細胞性腫瘍】2)骨髄異形成に関連した変化を有するAML(押味和夫(監修), 木崎昌弘, 田丸淳一(編))(中外医学社,東京)

      Pages: 125-128

    • Related Report
      2009 Annual Research Report
  • [Journal Article] Relationship Between Monoclonal Gammopathy of Undetermined Significance and Radiation Exposure in Nagasaki Atomic Bomb Survivors.2009

    • Author(s)
      Iwanaga M, et. al
    • Journal Title

      Blood 113 (8)

      Pages: 1639-1650

    • NAID

      120006982803

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Waldenstrom's Macroglobulinemia emerged in a patient with a 10-year stable lgG Monoclonal Gammopathy of Undetermined Significance2009

    • Author(s)
      Iwanaga M, et. al.
    • Journal Title

      Leukemia Research 33(1)

      Pages: 193-195

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 急性前骨髄球性白血病の治療-最近の動向2008

    • Author(s)
      宮崎泰司, 岩永正子
    • Journal Title

      血液・腫瘍科(科学評論社) 57(2)

      Pages: 199-206

    • NAID

      40019063869

    • Related Report
      2008 Annual Research Report
  • [Journal Article] 原爆白血病研究の過去・現在・未来2008

    • Author(s)
      朝長万左男
    • Journal Title

      長崎医学会誌 83(特集)

      Pages: 161-176

    • Related Report
      2008 Annual Research Report
  • [Journal Article] 近距離被爆後60年を経て発症し、寛解期の骨髄細胞と末梢血T細胞に多彩な染色体異常を認めた急性骨髄性白血病2008

    • Author(s)
      森脇祐司, 宮崎泰司, 他
    • Journal Title

      広島医学 61(4)

      Pages: 363-366

    • Related Report
      2008 Annual Research Report
  • [Journal Article] Expression of myeloperoxidase enhances the chemosensitivity of leukemia cells through the generation of reactive oxygen species and the nitration of protein.2008

    • Author(s)
      Sawayama Y, Miyazaki Y, et. al
    • Journal Title

      Leukemia 22(5)

      Pages: 956-964

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Presentation] 原爆被爆者における白血病・MDSなど血液疾患の疫学と病態2010

    • Author(s)
      岩永正子
    • Organizer
      第53回日本放射線影響学会シンポジウム
    • Place of Presentation
      京都テルサ
    • Year and Date
      2010-10-20
    • Related Report
      2010 Final Research Report
  • [Presentation] 原爆被爆者における白血病・MDSなど血液疾患の疫学と病態2010

    • Author(s)
      岩永正子
    • Organizer
      第53回日本放射線影響学会 シンポジウムS3.放射線誘発白血病:原爆疫学・分子メカニズムから予防法の開発まで
    • Place of Presentation
      京都テルサ
    • Year and Date
      2010-10-20
    • Related Report
      2010 Annual Research Report
  • [Presentation] Trends in human T-cell leukemia virus type-1 prevalence and the incidence of adult T-cell leukemia/lymphoma in Nagasaki, Japan.2009

    • Author(s)
      Iwanaga M, et al
    • Organizer
      American Society of Hematology (ASH), 51^<th> Annual Meeting and Exposition.
    • Place of Presentation
      Ernest N.Morial Convention Center, New Orleans, USA
    • Year and Date
      2009-12-05
    • Related Report
      2009 Annual Research Report
  • [Presentation] 原爆被爆者ガン診療データバンクの構築状況2009

    • Author(s)
      片岡未央, 他
    • Organizer
      第50回原子爆弾後障害研究会
    • Place of Presentation
      広島国際会議場
    • Year and Date
      2009-06-07
    • Related Report
      2009 Annual Research Report
  • [Presentation] 原爆後障害の現状と将来~造血器腫瘍からみた生涯持続性2009

    • Author(s)
      朝長万左男
    • Organizer
      原子爆弾被爆者指定医療機関等医師研究会
    • Place of Presentation
      長崎県農協会館7階701号会議室
    • Year and Date
      2009-02-06
    • Related Report
      2009 Annual Research Report
  • [Presentation] Prevalence of MGUS in atomic bomb survivors and incidence of WMin Japan2008

    • Author(s)
      Iwanaga M.
    • Organizer
      The 5 th International Workshop on Waldenstrom's Macroglobulinemia
    • Place of Presentation
      Stockholm, Sweden
    • Year and Date
      2008-10-16
    • Related Report
      2008 Annual Research Report
  • [Presentation] 血液疾患のコーディング:造血器腫瘍の臨床とWHO分類2008

    • Author(s)
      宮崎泰司
    • Organizer
      第17回地域がん登録全国協議会総会研究会
    • Place of Presentation
      長崎大学医学部良順会館
    • Year and Date
      2008-09-11
    • Related Report
      2010 Final Research Report
  • [Presentation] 血液疾患のコーディング(1)造血器腫瘍の臨床とWHO分類2008

    • Author(s)
      宮崎泰司
    • Organizer
      地域がん登録全国協議会 第17回総会研究会・がん登担当者集会 第2部 1. 実務担当者部会
    • Place of Presentation
      長崎大学医学部良順会館
    • Year and Date
      2008-09-11
    • Related Report
      2008 Annual Research Report
  • [Presentation] 原爆白血病研究の過去・現在・未来2008

    • Author(s)
      朝長万左男
    • Organizer
      第49回原子爆弾後障害研究会
    • Place of Presentation
      長崎原爆資料館
    • Year and Date
      2008-06-08
    • Related Report
      2010 Final Research Report
  • [Presentation] 招請講演1 : 白血病をめぐる先端医療の現状2008

    • Author(s)
      朝長万左男
    • Organizer
      第105回日本内科学会講演会
    • Place of Presentation
      東京国際フォーラム
    • Year and Date
      2008-04-11
    • Related Report
      2008 Annual Research Report
  • [Book] 新原爆放射線の人体影響([担当部分]後障害III.後障害の種類-放射線疫学の知5見1.原爆被爆(生存)者, 2)部位別がんリスク,m.白血病・骨髄異形成症候群(MDS))2011

    • Author(s)
      朝長万左男、岩永正子、宮崎泰司
    • Publisher
      文光堂(印刷中)
    • Related Report
      2010 Final Research Report
  • [Book] 新原爆放射線の人体影響((2)後障害 III.後障害の種類-放射線疫学の知見 1.原爆被爆(生存)者(2)部位別がんリスク m.白血病・骨髄異形成症候群(MDS))2011

    • Author(s)
      朝長万左男、岩永正子、宮崎泰司
    • Publisher
      文光堂(印刷中)
    • Related Report
      2010 Annual Research Report
  • [Book] みんなに役立つ骨髄異形成症候群(MDS)の 基礎と臨床(朝長万左男編)(I.基礎 II.疫学 V.治療, 他多数)2008

    • Author(s)
      朝長万左男, 岩永正子, 宮崎泰司
    • Total Pages
      314
    • Publisher
      医薬ジャーナル社
    • Related Report
      2010 Final Research Report
  • [Book] みんなに役立つ骨髄異形成症候群(MDS)の基礎と臨床(朝長万左男編)2008

    • Author(s)
      朝長万左男(I. 基礎), 岩永正子(II. 疫学). 宮崎泰司(V. 治療), 他
    • Total Pages
      314
    • Publisher
      (株)医薬ジャーナル社
    • Related Report
      2008 Annual Research Report
  • [Book] 新臨床内科学(高久文麿、尾形悦郎、黒川清、矢崎義雄、監修)2008

    • Author(s)
      朝長万左男, 第7章血液, 造血器疾患1. 急性白血病, 他
    • Total Pages
      2234
    • Publisher
      (株)医学書院
    • Related Report
      2008 Annual Research Report

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Published: 2008-04-01   Modified: 2016-04-21  

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