The fracture risk assessment tool using bone mineral density, risk factors and biochemical marker of bone turnover

• Project/Area Number: 20590661
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Public health/Health science
• Research Institution: Kinki University
• Principal Investigator: TAMAKI Junko Kinki University, 医学部, 准教授 (90326356)
• Co-Investigator(Kenkyū-buntansha): IKI Masayuki 近畿大学, 医学部, 教授 (50184388) ; FUJITA Yuuki 近畿大学, 医学部, 助教 (10330797)
• Project Period (FY): 2008 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000); Fiscal Year 2010: ¥390,000 (Direct Cost: ¥300,000、Indirect Cost: ¥90,000); Fiscal Year 2009: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000); Fiscal Year 2008: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
• Keywords: 骨密度 / 脆弱性骨折 / 骨代謝マーカー / 高齢男性 / コホート研究 / リスク評価 / 骨粗鬆症骨折 / リスク要因

Research Abstract

We conducted a baseline survey of the FORMEN Study among 2182 Japanese men aged≧65 years in 2008. The baseline database which included biochemical markers of bone turnover was completed. The clinical risk factors for fragility fracture, such as body mass index, smoking habit, were indicated to be associated with low bone mass. Furthermore, the vertebral deformity assessment at the baseline among 2012 men was completed. We ascertained 29 fragility fracture events until 2010, which number has not been enough to develop the model. The fracture risk assessment model would be completed in 2012 when the 5-year follow-up survey of the FORMEN study is conducted.

Research Products

• [Journal Article] Alcohol intake and bone status in elderly Japanese men : Baseline data from the Fujiwara-kyo Osteoporosis Risk in Men (FORMEN) Study. (2011)
  • Author(s): Kouda K, Iki M, Fujita Y, Tamaki J, Yura A, Kadowaki E, Sato Y, Moon JS, Morikawa M, Tomioka K, Okamoto N, Kurumatani N
  • Journal Title: Bone.
  • URL: http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6T4Y-52NW5P7-2&_user=6840639&_coverDate=04%2F21%2F2011&_rdoc=1&_fmt=high&_orig=gateway&_origin=gateway&_sort=d&_docanchor=&view=c&_searchStrId=1737087112&_rerunOrigin=google&_acct=C000009018&_version=1&_urlVersion=0&_userid=6840639&md5=0d2b64f817c824b02bf127d759c4fb64&searchtype=a
  • Peer Reviewed
• [Journal Article] Serum undercarboxylated osteocalcin levels are inversely associated with glycemic status and insulin resistance in an elderly Japanese male population : Fujiwara-kyo Osteoporosis Risk in Men (FORMEN) Study. (2011)
  • Author(s): Iki M, Tamaki, J, Fujita Y, Kouda K, Yura A, Kadowaki E, Sato Y, Moon JS, Tomioka K, Okamoto N, Kurumatani N
  • Journal Title: Osteoporos Int.
  • URL: http://www.springerlink.com/content/e8261050826168w1/
  • Peer Reviewed
• [Journal Article] Association between Vitamin K Intake from Fermented Soybeans, Natto, and Bone Mineral Density in Elderly Japanese Men : The Fujiwara-kyo Osteoporosis Risk in Men (FORMEN) Study. (2011)
  • Author(s): Fujita Y, Iki M, Tamaki J, Kouda K, Yura A, Kadowaki E, Sato Y, Moon JS, Tomioka K, Okamoto N, Kurumatani N
  • Journal Title: Osteoporos Int.
  • URL: http://www.springerlink.com/content/f748404w31m67818/
  • Peer Reviewed
• [Journal Article] Impact of smoking on bone mineral density and bone metabolism in elderly men : the Fujiwara-kyo Osteoporosis Risk in Men (FORMEN) study. (2011)
  • Author(s): Tamaki J, Iki M, Fujita Y, Kouda K, Yura A, Kadowaki E, Sato Y, Moon JS, Tomioka K, Okamoto N, Kurumatani N.
  • Journal Title: Osteoporos Int. Volume: 22(1) Pages: 133-141
  • Peer Reviewed
• [Journal Article] Impact of smoking on bone mineral density and bone metabolism in elderly men : the Fujiwara-kyo Osteoporosis Risk in Men (FORMEN) study. (2010)
  • Author(s): Tamaki J, Iki M, Fujita Y, Kouda K, Yura A, Kadowaki E, Sato Y, Moon JS, Tomioka K, Okamoto N, Kurumatani N
  • Journal Title: Osteoporos Int.
  • Peer Reviewed
• [Journal Article] (Fujiwara-kyo Study Group). Design and baseline characteristics of a prospective cohort study for determinants of osteoporotic fracture in community-dwelling elderly Japanese men : the Fujiwara-kyo osteoporosis risk in men (FORMEN) study. (2009)
  • Author(s): Iki M, Fujita Y, Tamaki J, Kouda K, Yura A, Kadowaki E, Sato Y, Moon JS, Okamoto N, Kurumatani N
  • Journal Title: BMC Musculoskelet Disord. 10 Pages: 165-165
  • Peer Reviewed
• [Journal Article] Design and baseline characteristics of a prospective cohort study for determinants of osteoporotic fracture in community-dwellimg elderly Japanese men : the Fujiwara-kyo Osteoporosis Risk in Men(FORMEN)Study (2009)
  • Author(s): Masayuki Iki
  • Journal Title: BMC Musculoskeletal Disorders 10 Pages: 165-165
  • Peer Reviewed
• [Presentation] 藤原京スタディグループ.日本人高齢男性では血清低カルボキシル化オステオカルシン濃度が空腹時血糖値・ヘモグロビンA1c値と逆相関した。藤原京スタディ男性骨粗鬆症(FORMEN)研究 (2011)
  • Author(s): 伊木雅之
  • Organizer: 日本内分泌学会
  • Place of Presentation: 神戸
• [Presentation] HMG-CoA還元酵素阻害剤は骨量低下を抑制するか-藤原京スタディ男性骨折コホート研究の断面検討 (2011)
  • Author(s): 玉置淳子,伊木雅之,藤田裕規,甲田勝康,由良晶子,門脇英子,佐藤裕保,文鐘聲,冨岡公子,岡本希,車谷典男
  • Organizer: 日本疫学会
  • Place of Presentation: 札幌
• [Presentation] 骨代謝における軽度・中等度腎機能低下の影響 ～藤原京スタディ男性骨粗鬆症コホート研究～ (2011)
  • Author(s): 藤田裕規,伊木雅之,玉置淳子,甲田勝康,由良晶子,門脇英子,佐藤裕保,文鐘聲,冨岡公子,岡本希,車谷典男
  • Organizer: 日本疫学会
  • Place of Presentation: 札幌
• [Presentation] 骨代謝における軽度・中等度腎機能低下の影響～藤原京スタディ男性骨粗鬆症コホート研究～ (2011)
  • Author(s): 藤田裕規
  • Organizer: 日本疫学会
  • Place of Presentation: 札幌
• [Presentation] IMPACT OF SMOKING ON BONE MINERAL DENSITY IN ELDERLY MEN : THE FUJIWARA-KYO OSTEOPOROSIS RISK IN MEN(FORMEN)STUDY (2010)
  • Author(s): 玉置淳子
  • Organizer: The International Society For Clinical Densitometry
  • Place of Presentation: 米国テキサス州サンアトニオ市
  • Year and Date: 2010-03-10
• [Presentation] Baseline data of a cohort study for determinants of osteoporotic fracture in community-dwelling elderly Japanese men : the Fujiwara-kyo Osteoporosis Risk in Men(FORMEN)Study (2010)
  • Author(s): Masayuki Iki
  • Organizer: 国際疫学会西太平洋地域学術会議兼第20回日本疫学会学術総会
  • Place of Presentation: 埼玉県立大学
  • Year and Date: 2010-01-09
• [Presentation] Serum undercarboxylated osteocalcin levels are inversely associated with glycemic status and insulin resistance in an elderly Japanese male population: Fujiwara-kyo Osteoporosis Risk in Men (FORMEN) Study. (2010)
  • Author(s): Iki M, Tamaki J, Fujita Y, Kouda K, Yura A, Kadowaki E, Sato Y, Moon JS, Tomioka K, Okamoto N, Kurumatani N
  • Organizer: IOF Asian-Pacific Osteoporosis Meeting
  • Place of Presentation: Singapore
• [Presentation] 習慣的牛乳飲用は男性高齢者でも高骨密度に関連する-藤原京スタディ男性骨粗鬆症研究 (2010)
  • Author(s): 佐藤裕保,伊木雅之,藤田裕規,玉置淳子,甲田勝康,由良晶子,門脇英子, 文鐘聲,冨岡公子,岡本希,車谷典男
  • Organizer: 日本公衆衛生学会
  • Place of Presentation: 東京
• [Presentation] 高齢者における慢性腎臓病有病状況とその循環器リスク要因への影響-藤原京スタディ- (2010)
  • Author(s): 伊木雅之,玉置淳子,藤田裕規,甲田勝康,由良晶子,門脇英子,冨岡公子,岡本希,車谷典男
  • Organizer: 日本公衆衛生学会
  • Place of Presentation: 東京
• [Presentation] 日本人高齢男性では、推定糸球体濾過量は骨密度と逆相関した -藤原京スタディ男性骨粗鬆症(FORMEN)研究- (2010)
  • Author(s): 伊木雅之,藤田裕規,玉置淳子,甲田勝康,由良晶子,門脇英子,佐藤裕保,文鐘聲,岡本希,車谷典男
  • Organizer: 日本骨粗鬆症学会
  • Place of Presentation: 大阪
• [Presentation] 日本人高齢男性では血清オステオカルシン濃度は空腹時血糖値、並びにヘモグロビンA1c値と逆相関する。藤原京スタディ男性骨粗鬆症(FORMEN)研究 (2010)
  • Author(s): 伊木雅之,藤田裕規,玉置淳子,甲田勝康,由良晶子,門脇英子,佐藤裕保,岡本希,車谷典男
  • Organizer: 日本骨代謝学会
  • Place of Presentation: 東京
• [Presentation] 適度な飲酒は骨粗鬆症を防ぐ-藤原京スタディ男性骨粗鬆症コホート研究- (2010)
  • Author(s): 甲田勝康,伊木雅之,藤田裕規,玉置淳子,由良晶子,門脇英子,佐藤裕保,文鐘聲,森川,冨岡公子,岡本希,車谷典男
  • Organizer: 日本公衆衛生学会
  • Place of Presentation: 奈良
• [Presentation] 禁煙は骨密度低下の速度を下げる-藤原京スタディ男性骨粗鬆症コホート研究の断面検討 (2010)
  • Author(s): 玉置淳子,伊木雅之,藤田裕規,甲田勝康,由良晶子,門脇英子,佐藤裕保,文鐘聲,冨岡公子,岡本希,車谷典男
  • Organizer: 日本公衆衛生学会
  • Place of Presentation: 奈良
• [Presentation] 納豆摂取による骨密度低下の予防効果 ～藤原京スタディ男性骨粗鬆症コホート研究～ (2010)
  • Author(s): 藤田裕規,伊木雅之,玉置淳子,甲田勝康,由良晶子,門脇英子,佐藤裕保,文鐘聲,冨岡公子,岡本希,車谷典男
  • Organizer: 日本公衆衛生学会
  • Place of Presentation: 奈良(優秀演題賞)
• [Presentation] 捨て置かれし男性の骨を守ろう!藤原京スタディ男性骨粗鬆症コホート研究の発進 (2010)
  • Author(s): 伊木雅之,藤田裕規,玉置淳子,甲田勝康,由良晶子,門脇英子,佐藤裕保,文鐘聲,岡本希,車谷典男
  • Organizer: 日本公衆衛生学会
  • Place of Presentation: 奈良
• [Presentation] 藤原京スタディ男性骨粗鬆症コホート研究の発進 (2010)
  • Author(s): 伊木雅之,藤田裕規,玉置淳子,甲田勝康,由良晶子,門脇英子,佐藤裕保,文鐘聲,岡本希,車谷典男
  • Organizer: 日本骨粗鬆症学会
  • Place of Presentation: 名古屋
• [Presentation] SUBCLINICAL DECLINE IN RENAL FUNCTION WAS ASSOCIATED WITH INCREASED BONE DENSITY IN A JAPANESE ELDERLY MALE POPULATION : FORMEN STUDY. (2010)
  • Author(s): Iki M, Fujita Y, Tamaki J, Kouda K, Yura A, Kadowaki E, Sato Y, Moon JS, Tomioka K, Okamoto N, Kurumatani N
  • Organizer: IOF-ECCEO10
  • Place of Presentation: Firenze
• [Presentation] Baseline data of a cohort study for determinants of osteoporotic fracture in community-dwelling elderly Japanese men : the Fujiwara-kyo Osteoporosis Risk in Men (FORMEN) Study. (2010)
  • Author(s): Iki M, Fujita Y, Tamaki J, Kouda K, Yura A, Kadowaki E, Sato Y, Moon JS, Morikawa M, Tomioka K, Okamoto N, Kurumatani N
  • Organizer: IEQWP/JEA
  • Place of Presentation: Koshigaya
• [Presentation] SUBCLINICAL DECLINE IN RENAL FUNCTION WAS ASSOCIATED WITH INCREASED BONE DENSITY IN A JAPANESE ELDERLY MALE POPULATION : FORMEN STUDY. (2010)
  • Author(s): Iki M
  • Organizer: IOF-ECCE010
  • Place of Presentation: Firenze
• [Presentation] 日本人高齢男性では血清オステオカルシン濃度は空腹時血糖値、並びにヘモグロビンAlc値と逆相関する。藤原京スタディ男性骨粗鬆症(FORMEN)研究. (2010)
  • Author(s): 伊木雅之
  • Organizer: 日本骨代謝学会
  • Place of Presentation: 東京
• [Presentation] 日本人高齢男性では、推定糸球体濾過量は骨密度と逆相関した-藤原京スタディ男性骨粗鬆症(FORMEN)研究- (2010)
  • Author(s): 伊木雅之
  • Organizer: 日本骨粗鬆症学会
  • Place of Presentation: 大阪
• [Presentation] 習慣的牛乳飲用は男性高齢者でも高骨密に関連する-藤原京スタディ男性骨粗鬆症研究 (2010)
  • Author(s): 佐藤裕保
  • Organizer: 日本公衆衛生学会
  • Place of Presentation: 東京
• [Presentation] Serum undercarboxylated osteocalcin levels are inversely associated with glycemic status and insulin resistance in an elderly Japanese male population : Fujiwara-kyo Osteoporosis Risk in Men (FORMEN) Study. (2010)
  • Author(s): Iki M
  • Organizer: IOF Asian-Pacific Osteoporosis Meeting
  • Place of Presentation: Singapore
• [Presentation] 喫煙年数が長いほど骨密度は低い-藤原京スタディ男性骨粗鬆症コホート研究の断面検討 (2009)
  • Author(s): 玉置淳子
  • Organizer: 第68回日本公衆衛生学会
  • Place of Presentation: 奈良県文化会館
  • Year and Date: 2009-10-22
• [Presentation] 捨て置かれし男性の骨を守ろう!藤原京スタディ男性骨粗鬆症コホート研究の発進 (2009)
  • Author(s): 伊木雅之
  • Organizer: 第68回日本公衆衛生学会
  • Place of Presentation: 奈良県文化会館
  • Year and Date: 2009-10-22
• [Presentation] 納豆摂取による骨密度低下の予防効果～藤原京スタディ男性骨粗鬆症コホート研究 (2009)
  • Author(s): 藤田裕規
  • Organizer: 第68回日本公衆衛生学会
  • Place of Presentation: 奈良県文化会館
  • Year and Date: 2009-10-22
• [Remarks] Medical Tribune.2010 May 44;10:11.
• [Remarks] 雑誌2件目掲載URL
  • URL: http://www.biomedcentral.com/1471-2474/10/165