Objective Method for Evaluating the Fatigue State of Crushing Labor

• Project/Area Number: 20590662
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Public health/Health science
• Research Institution: Kansai University of Welfare Sciences
• Principal Investigator: KURATSUNE Hirohiko Kansai University of Welfare Sciences, 健康福祉学部, 教授 (50195533)
• Co-Investigator(Kenkyū-buntansha): TAJUIMA Seiki 兵庫県立総合リハビリテーションセンターリハビリテーション中央病院, 子どもの睡眠と発達医療センター, 医師 (30420722)
• Project Period (FY): 2008 – 2010
• Project Status: Completed (Fiscal Year 2010)
• Budget Amount: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000); Fiscal Year 2010: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000); Fiscal Year 2009: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2008: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
• Keywords: 過重労働 / 疲労 / バイオマーカー / 自律神経機能 / 酸化ストレス / 産業疲労特定検診 / 心拍変動解析 / トータルパワー値 / 自律神経系バランス(IF/HF比) / 主観的疲労度 / アクティグラフ / 唾液アミラーゼ

Research Abstract

We studied the fatigue state of crushing labor by using not only a questionnaire, but also several objective biomarkers such as the autonomic function, the amount and intensity of human activity, and the oxidation and anti-oxidation activities. The results from the autonomic function judging by the A-A interval power spectrum analysis for acceleration plethysmogram lead to early detection of the mental health disorders and the fatigue state without feeling of fatigue. Most of them who had sympathetic hyperactivity in the rest with closed eyes had a deterioration of sleep quality. Furthermore, the evaluation of oxidation and anti-oxidation activities by using the d-ROMs test and the BAP test reflects not only the clinical condition with or without fatigue state, but also the etiology of fatigue state. Therefore, these evaluations might make useful objective markers for diagnostic evaluation of fatigue states.

Research Products

• [Journal Article] Mental fatigue caused by prolonged cognitive load associated with (2011)
  • Author(s): Mizuno K, Tanaka M, Yamaguti K, Kajimoto O, Kuratsune H, Watanabe Y.
  • Journal Title: sympathetic hyperactivity. Behav Brain Funct.(In press)
  • Peer Reviewed
• [Journal Article] Oxidation stress index as a possible clinical marker for the clinical evaluation of non-Hodgkin lymphoma. (2011)
  • Author(s): Nojima J, Motoki Y, Tsuneoka H., Kuratsune H, Matsui T, Yamamoto M, Yanagihara M, Hinoda Y, Ichihara K.
  • Journal Title: Br J Haematol (In press)
  • Peer Reviewed
• [Journal Article] "Oxidation stress index" as a possible clinical marker for the clinical evaluation of non-Hodgkin lymphoma. (2011)
  • Author(s): Nojima J, Motoki Y, Tsuneoka H., Kuratsune H, Matsui T, Yamamoto M, Yanagihara M, Hinoda Y, Ichihara K
  • Journal Title: Br J Haematol Volume: (In press)
  • Peer Reviewed
• [Journal Article] No association of xenotropic murine leukemia virus-related virus with prostate cancer or chronic fatigue syndrome in Japan. (2011)
  • Author(s): Furuta RA, Miyazawa T, Sugiyama T, Kuratsune H, Ikeda Y, Sato E, Misawa N, Nakatomi Y, Sakuma R, Yasui K, Yamaguti K, Hirayama F.
  • Journal Title: Retrovirology Volume: 8(電子ジャーナル) Pages: 20-20
  • Peer Reviewed
• [Journal Article] The increase of alpha-melanocytestimulating hormone in the plasma of chronic fatigue syndrome patients. (2010)
  • Author(s): Shishioh-Ikejima N, Ogawa T, Yamaguti K, Watanabe Y,Kuratsune H, Kiyama H.
  • Journal Title: BMC Neurol. Vol.10 Pages: 73-73
  • Peer Reviewed
• [Journal Article] Medial Orbitofrontal Cortex Is Associated with Fatigue Sensation. (2010)
  • Author(s): Tajima S., Yamamoto S., Tanaka M.,Kataoka Y., Iwase M., Yoshikawa E., Okada H., Onoe H., Tsukada H., Kuratsune H., Ouchi Y., Watanabe Y.
  • Journal Title: Neuro Res Int Pages: 2010-2010
  • Peer Reviewed
• [Journal Article] Effect of crocetin from Gardenia Jasminoides Ellis on sleep : A pilot study. (2010)
  • Author(s): Kuratsune H, Umigai N, Takeno R, Kajimoto Y, Nakano T.
  • Journal Title: Phytomedicine Vol.17、No.11 Pages: 840-843
  • Peer Reviewed
• [Journal Article] A functional polymorphism in the Disrupted-in schizophrennia 1 gene is associated with chronic fatigue syndrome. (2010)
  • Author(s): Fukuda S., Hashimoto R., Ohi K., Yamaguti K., Nakatomi Y.,Yasuda Y., Kamino K., Takeda M., Tajima S., Kuratsune H., Nishizawa Y., Watanabe Y.
  • Journal Title: Life Sciences Vol.86 Pages: 722-725
  • Peer Reviewed
• [Journal Article] Fatigue is a predictor for cardiovascular outcomes in patients undergoing hemodialysis (2010)
  • Author(s): Koyama H., Fukuda S., Shoji T., Inaba M., Tsujimoto Y., Tabata T., Okuno S., Yamakawa T., Okada S., Okamura M., Kuratsune H., Fujii H., Hirayama Y., Watanabe Y., Nishizawa Y.
  • Journal Title: Clin J Am Soc Nephrology Vol.5 Pages: 659-666
  • Peer Reviewed
• [Journal Article] Premorbid personality in chronic fatigue syndrome as determined by the Temperament and Character Inventory. (2010)
  • Author(s): Fukuda S, Kuratsune H, Tajima S, Takashima S, Yamagutchi K, Nsizawa Y, Watanabe Y.
  • Journal Title: Comr Psychiatry Vol.51 Pages: 78-85
  • Peer Reviewed
• [Journal Article] 産業疲労検診の必要性と有用性 (2010)
  • Author(s): 田島世貴、倉恒弘彦
  • Journal Title: 日本疲労学会誌 Vol.5、No.2 Pages: 42-47
  • Peer Reviewed
• [Journal Article] The increase of alpha-melanocyte-stimulating hormone in the plasma of chronic fatigue syndrome patients. (2010)
  • Author(s): Shishioh-Ikejima N, Ogawa T, Yamaguti K, Watanabe Y, Kuratsune H, Kiyama H.
  • Journal Title: BMC Neurol. Volume: 10(電子ジャーナル) Pages: 73-73
  • Peer Reviewed
• [Journal Article] Medial Orbitofrontal Cortex Is Associated with Fatigue Sensation. (2010)
  • Author(s): Tajima S., Yamamoto S., Tanaka M., Kataoka Y., Iwase M., Yoshikawa E., Okada H., Onoe H., Tsukada H., Kuratsune H., Ouchi Y., Watanabe Y.
  • Journal Title: Neuro Res Int Volume: (電子ジャーナル) Pages: 2010-2010
  • Peer Reviewed
• [Journal Article] Effect of crocetin from Gardenia Jasminoides Ellis on sleep : A pilot study. (2010)
  • Author(s): Kuratsune H, Umigai N, Takeno R, Kajimoto Y, Nakano T.
  • Journal Title: Phytomedicine Volume: 17(11) Pages: 840-843
  • Peer Reviewed
• [Journal Article] A functional polymorphism in the Disrupted-in schizophrennia 1 gene is associated with chronic fatigue syndrome. (2010)
  • Author(s): Fukuda S, Hashimoto R, Ohi K, Yamaguti K, Nakatomi Y, Yasuda Y., Kamino K., Takeda M, Tajima S, Kuratsune H, Nishizawa Y, Watanabe Y.
  • Journal Title: Life Sciences Volume: 86(19-20) Pages: 722-725
  • Peer Reviewed
• [Journal Article] Fatigue is a predictor for cardiovascular outcomes in patients undergoing hemodialysis. (2010)
  • Author(s): Koyama H, Fukuda S, Shoji T, Inaba M, Tsujimoto Y, Tabata T, Okuno S, Yamakawa T, Okada S, Okamura M, Kuratsune H, Fujii H, Hirayama Y, Watanabe Y, Nishizawa Y.
  • Journal Title: Clin J Am Soc Nephrology Volume: 5(4) Pages: 659-666
  • Peer Reviewed
• [Journal Article] Premorbid personality in chronic fatigue syndrome as determined by the Temperament and Character Inventory. (2010)
  • Author(s): Fukuda S, Kuratsune H, Tajima S, Takashima S, Yamagutchi K, Nsizawa Y, Watanabe Y.
  • Journal Title: Comr Psychiatry Volume: 51(1) Pages: 78-85
  • Peer Reviewed
• [Journal Article] 産業疲労検診の必要性と有用性 (2010)
  • Author(s): 田島世貴、倉恒弘彦
  • Journal Title: 日本疲労学会誌 Volume: 5(2) Pages: 42-47
  • Peer Reviewed
• [Journal Article] 森林環境における疲労回復効果の科学的検証 (2010)
  • Author(s): 倉恒弘彦、田島世貴、西牧真里、大川尚子、藤原和美、池上徹、廣澤巖夫、三戸秀樹、宗清芳美、局博一、倉恒大輔、笹部哲也、山口浩二、大平辰朗、塩見格一、小泉淳一
  • Journal Title: 日本疲労学会誌 Volume: 5(2) Pages: 35-41
  • Peer Reviewed
• [Journal Article] 日本における慢性疲労の実態と慢性疲労病態 (2010)
  • Author(s): 倉恒弘彦
  • Journal Title: アンチ・エイジング医学-日本抗加齢医学会雑誌 Volume: 6(3) Pages: 335-342
• [Journal Article] 生理学的バイオマーカーによる疲労の計測 (2010)
  • Author(s): 田島世貴、山口浩二、倉恒弘彦
  • Journal Title: アンチ・エイジング医学-日本抗加齢医学会雑誌 Volume: 6(3) Pages: 329-334
• [Journal Article] A functional polymorphism in the Disrupted-in schizophrennia 1 gene is associated with chronic fatigue syndrome. (2010)
  • Author(s): Fukuda S., Hashimoto R., Ohi K., Yamaguti K., Nakatomi Y., Yasuda Y., Kamino K., Takeda M., Tajima S., Kuratsune H., Nishizawa Y., Watanabe Y.
  • Journal Title: Life Sciences 86 Pages: 722-725
  • Peer Reviewed
• [Journal Article] Fatigue is a predictor for cardiovascular outcomes in patients undergoing hemodialysis. (2010)
  • Author(s): Koyama H., Fukuda S., Shoji T., Inaba M., Tsujimoto Y., Tabata T., Okuno S., Yamakawa T., Okada S., Okamura M., Kuratsune H., Fujii H., Hirayama Y., Watanabe Y., Nishizawa Y.
  • Journal Title: Clin J Am Soc Nephrology 5 Pages: 659-666
  • Peer Reviewed
• [Journal Article] Stress and coping style are associated with severe fatigue in medical students. (2009)
  • Author(s): Tanaka M., Fukuda S., Mizuno K., Yoshida K., Kuratsune H., Watanabe Y.
  • Journal Title: Behavioral Medicine Vol.35 Pages: 87-92
  • Peer Reviewed
• [Journal Article] A two-year follow-up study of chronic fatigue syndrome comorbid with psychiatric disorders. (2009)
  • Author(s): Matsuda Y., Matsui T., Kataoka K., Fukuda R., Fukuda S., Kuratsune H., Tajima S., Yamaguti K., Kato YH., Kiriike N.
  • Journal Title: Psychiatry Clin Neurosci Vol.63 Pages: 365-373
  • Peer Reviewed
• [Journal Article] (2009)
  • Author(s): Mizuma H., Tanaka M., Nozaki S., Mizuno K., Tahara T., Ataka S., Sugino T., Shirai T., Kajimoto Y., Kuratsune H., Kajimoto O., Watanabe Y.、Mizuma H., Tanaka M., Nozaki S., Mizuno K., Tahara T., Ataka S., Sugino T., Shirai T., Kajimoto Y., Kuratsune H., Kajimoto O., Watanabe Y.
  • Journal Title: Nutr Res. Vol.29 Pages: 145-150
  • Peer Reviewed
• [Journal Article] Non-invasive prediction of hematocrit levels by portable visible and near-infrared spectroshotometer. (2009)
  • Author(s): Sakudo A., Kato Y.H., Kuratsune H., Ikuta K.
  • Journal Title: Clinica Chimica Acta 408 Pages: 123-127
  • Peer Reviewed
• [Journal Article] Stress and coping style are associated with severe fatigue in medical students. (2009)
  • Author(s): Tanaka M., Fukuda S., Mizuno K., Yoshida K, Kuratsune H., Watanabe Y.
  • Journal Title: Behavioral Medicine 35 Pages: 87-92
  • Peer Reviewed
• [Journal Article] A two-year follow-up study of chronic fatigue syndrome comorbid with psychiatric disorders. (2009)
  • Author(s): Matsuda Y., Matsui T., Kataoka K., Fukuda R., Fukuda S., Kuratsune H., Tajima S., Yamaguti K., Kato YH., Kiriike N.
  • Journal Title: Psychiatry Clin Neurosci 63 Pages: 365-373
  • Peer Reviewed
• [Journal Article] Daily oral administration of crocetin attenuates physical fatigue in human subjects. (2009)
  • Author(s): Mizuma H., Tanaka M., Nozaki S., Mizuno K., Tahara T., Ataka S., Sugino T., Shirai T., Kajimoto Y., Kuratsune H., Kajimoto O., Watanabe Y.
  • Journal Title: Nutr Res. 29 Pages: 145-150
  • Peer Reviewed
• [Journal Article] Visible and near-infrared spectral changes in the thumb of patients with chronic fatigue syndrome. (2009)
  • Author(s): Sakudo A., Kato Y.H., Tajima S., Kuratsune H., Ikuta K.
  • Journal Title: Clinica Chimica Acta 403 Pages: 163-166
  • Peer Reviewed
• [Journal Article] 産業疲労特定検診 (2009)
  • Author(s): 倉恒弘彦, 倉恒邦比古
  • Journal Title: 医学のあゆみ 228(6) Pages: 737-742
• [Journal Article] 慢性疲労からの脱却第12回産業疲労特定検診 (2009)
  • Author(s): 倉恒弘彦
  • Journal Title: 健康日本 492(3) Pages: 20-21
• [Journal Article] 疲労の客観的評価加速度脈波を用いた方法 (2008)
  • Author(s): 山口浩二, 笹部哲也, 倉恒弘彦, 西沢良記, 渡辺恭良
  • Journal Title: 精神医学 50(6) Pages: 533-542
  • Peer Reviewed
• [Presentation] The pathogenesis of patients with chronic fatigue syndrome (CFS)-the association of brain dysfunction or XMRV infection with CFS in Japan. (2010)
  • Author(s): Hirohiko Kuratsune
  • Organizer: 第33回日本神経科学学会、第53回日本神経化学学会、第20回日本神経回路学会、合同大会
  • Place of Presentation: 神戸コンベンションセンター(神戸)
  • Year and Date: 2010-09-04
• [Presentation] 大学生における疲労、抑うつと食との関係 (2010)
  • Author(s): 倉恒弘彦
  • Organizer: 第32回日本臨床栄養学会総会・第31回日本臨床栄養協会総会、第8回大連合大会
  • Place of Presentation: 名古屋国際会議場(名古屋)
  • Year and Date: 2010-08-28
• [Presentation] 疲労病態における睡眠リズム解析 (2010)
  • Author(s): 田島世貴、山口浩二、中富康仁、倉恒弘彦
  • Organizer: 第6回日本疲労学会総会・学術集会
  • Place of Presentation: 大阪産業創造館(大阪)(シンポジウム3)
  • Year and Date: 2010-06-26
• [Presentation] 慢性疲労に見る自律神経系失調 (2010)
  • Author(s): 山口浩二、笹部哲也、中富康仁、田島世貴、倉恒弘彦、西沢良記、渡辺恭良
  • Organizer: 第6回日本疲労学会総会・学術集会
  • Place of Presentation: 大阪産業創造館(大阪)(シンポジウム3)
  • Year and Date: 2010-06-26
• [Presentation] 予防医療を目的とした自律神経機能検査 (2010)
  • Author(s): 小泉淳一、増田久美子、瀬古裕也、西田優、田島世貴、倉恒弘彦
  • Organizer: 第6回日本疲労学会総会・学術集会
  • Place of Presentation: 大阪産業創造館(大阪)(シンポジウム3)
  • Year and Date: 2010-06-26
• [Presentation] CFS患者の転帰に及ぼす併存する精神障害の影響について (2010)
  • Author(s): 松井徳造、松田泰範、片岡浩平、深田亮介、福田早苗、倉恒弘彦、田島世貴、山口浩二、計屋由希子、切池信夫
  • Organizer: 第6回日本疲労学会総会・学術集会
  • Place of Presentation: 大阪産業創造館(大阪)
  • Year and Date: 2010-06-26
• [Presentation] 慢性疲労症候群における脳内免疫異常に対するPET研究:第1報 (2010)
  • Author(s): 中富康仁、水野敬、和田康弘、田中雅彰、高橋和弘、田沢周作、重松誠、尾上嘉代、鴫原良仁、石井聡、小山英則、松井徳造、片岡洋祐、川邉譲治、山口浩二、塩見進、西沢良記、倉恒弘彦、渡辺恭良
  • Organizer: 第6回日本疲労学会総会・学術集会
  • Place of Presentation: 大阪産業創造館(大阪)
  • Year and Date: 2010-06-26
• [Presentation] 10項目質問表による慢性疲労症候群スクリーニング評価の試み (2010)
  • Author(s): 田島世貴、山口浩二、中富康仁、倉恒弘彦
  • Organizer: 第6回日本疲労学会総会・学術集会
  • Place of Presentation: 大阪産業創造館(大阪)
  • Year and Date: 2010-06-26
• [Presentation] アトピー性皮膚炎患者における疲労調査 (2010)
  • Author(s): 宮久詩、小林裕美、柳原茂人、鶴田大輔、水野信之、石井正光、野島順三、中富康仁、山口浩二、倉恒弘彦
  • Organizer: 第6回日本疲労学会総会・学術集会
  • Place of Presentation: 大阪産業創造館(大阪)
  • Year and Date: 2010-06-26
• [Presentation] クチナシ果実由来カロテノイド「クロセチン」の睡眠改善効果 (2010)
  • Author(s): 海貝尚史、杉野友啓、梶本佳孝、倉恒弘彦
  • Organizer: 第6回日本疲労学会総会・学術集会
  • Place of Presentation: 大阪産業創造館(大阪)
  • Year and Date: 2010-06-26
• [Presentation] 芳香物質が自律神経に与える影響について-慢性疲労症候群患者と健常者の比較- (2010)
  • Author(s): 笹部哲也、福田早苗、山口浩二、中富康仁、神楽美香、倉恒弘彦、渡辺恭良
  • Organizer: 第6回日本疲労学会総会・学術集会
  • Place of Presentation: 大阪産業創造館(大阪)
  • Year and Date: 2010-06-26
• [Presentation] 精神作業疲労に対する森林浴の疲労回復効果 (2010)
  • Author(s): 川尚子、田島世貴、藤原和美、池上徹、廣澤巖夫、三戸秀樹、倉恒大輔、大平辰朗、塩見格一、小泉淳一、笹部哲也、山口浩二、倉恒弘彦
  • Organizer: 第6回日本疲労学会総会・学術集会
  • Place of Presentation: 大阪産業創造館(大阪)
  • Year and Date: 2010-06-26
• [Presentation] 慢性疲労研究のこれまでの歩み (2010)
  • Author(s): 倉恒弘彦
  • Organizer: 第6回日本疲労学会総会・学術集会
  • Place of Presentation: 大阪産業創造館(大阪)(会長講演)
  • Year and Date: 2010-06-25
• [Presentation] 疲労モデル動物および慢性疲労症候群患者を対象としたメタボローム解析 (2010)
  • Author(s): 片岡洋祐、金光華、山野恵美、田島世貴、中富康仁、倉恒弘彦、渡辺恭良、合田亘人、岩井一宏、曽我朋義
  • Organizer: 第6回日本疲労学会総会・学術集会
  • Place of Presentation: 大阪産業創造館(大阪)(シンポジウム1)
  • Year and Date: 2010-06-25
• [Presentation] DNAチップによる慢性疲労症候群の診断法の開発 (2010)
  • Author(s): 吉田雄一郎、小林雅樹、田島世貴、中富康仁、山口浩二、六反一仁、渡辺恭良、大友泰裕、倉恒弘彦
  • Organizer: 第6回日本疲労学会総会・学術集会
  • Place of Presentation: 大阪産業創造館(大阪)(シンポジウム1)
  • Year and Date: 2010-06-25
• [Presentation] Brain and Autonomic dysfunction under the Fatigue and Stressful Condition. (2010)
  • Author(s): 倉恒弘彦
  • Organizer: シンポジウム 第83回日本薬理学会年会
  • Place of Presentation: 大阪
  • Year and Date: 2010-03-16
• [Presentation] Brain and Autonomic dysfunction under the Fatigue and Stressful Condition. (2010)
  • Author(s): Kuratsune H.
  • Organizer: シンポジウム 第83回日本薬理学会年会
  • Place of Presentation: (大阪)
  • Year and Date: 2010-03-16
• [Presentation] 馬介在療法の科学的効果-内科医の視点から-動物とヒトが共存する健康な社会 (2010)
  • Author(s): 倉恒弘彦
  • Organizer: 第7回北里大学農医連携シンポジウム
  • Place of Presentation: (東京)
  • Year and Date: 2010-03-04
• [Presentation] アロマセラピートリートメントの効果の科学的検証 (2010)
  • Author(s): 小川佳苗、垣本美香、山本直美、倉恒弘彦
  • Organizer: The International Federation of Aromatherapists-25周年記念総会
  • Place of Presentation: 東京有明TOCコンベンション・ホール(東京)
• [Presentation] Changes in autonomic nerve function in the mental fatigue state caused by long-term computerized Kraepelin test workload. (2009)
  • Author(s): H.Kuratsune.
  • Organizer: The 36th Congress of the International Union of Physiological Sciences.
  • Place of Presentation: (Kyoto, Japan)
• [Presentation] 慢性疲労に陥るメカニズムとその評価法 (2008)
  • Author(s): 倉恒弘彦
  • Organizer: 第24回日本ストレス学会学術総会(シンポジウム)
  • Place of Presentation: 大阪
  • Year and Date: 2008-10-31
• [Book] 疲労の分子神経メカニズムヒューマンインターフェースのための計測と制御(監修 : 山口昌樹) (2009)
  • Author(s): 倉恒弘彦
  • Publisher: シーエムシー出版