The impact of plasma homocysteine and B complex vitamins on subclinical atherosclerosis amongst community-dwelling American and Japanese men
| Project/Area Number |
20590670
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Public health/Health science
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| Research Institution | National Cardiovascular Center Research Institute |
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Principal Investigator |
OKAMURA Tomonori National Cardiovascular Center Research Institute, 医学部, 教授 (00324567)
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| Co-Investigator(Renkei-kenkyūsha) |
UESHIMA Hirotsugu 滋賀医科大学, 医学部, 特任教授 (70144483)
KADOWAKI Takashi 滋賀医科大学, 医学部, 客員助教 (30324578)
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| Project Period (FY) |
2008 – 2010
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| Project Status |
Completed (Fiscal Year 2010)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2010: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2009: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2008: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | ホモシステイン / 葉酸 / 冠動脈石灰化 / 内膜中膜複合体 / 日米比較 / 酸化LDLコレステロール / 飲酒 / 生活習慣 / 多変量解析 / ビタミンB12 |
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| Research Abstract |
Randomly selected community-based populations of 287 Japanese and 296 US men aged 40-49 were examined for intima-media thickness (IMT) of common carotid artery and coronary calcium in a previous survey. We measured plasma homocysteine and serum folate levels by stored blood sample. Plasma homocysteine levels are much lower in US participants than Japanese participants irrespective of more unfavorable subclinical atherosclerotic findings. Furthermore, we are not able to observe any relationship between plasma homocysteine or serum folate levels and above-mentioned subclinical atherosclerotic findings in both populations.
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Report
(4 results)
Research Products
(12 results)
