| Project/Area Number |
20590672
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Public health/Health science
|
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| Research Institution | Radiation Effects Research Foundation |
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Principal Investigator |
OHISHI Waka Radiation Effects Research Foundation, 広島臨床研究部, 臨床検査科長 (20393423)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
FUJIWARA Saeko 財団法人 放射線影響研究所, 広島臨床研究部, 部長 (70359454)
COLOGNE John 財団法人 放射線影響研究所, 統計部, 任期付研究員 (50344411)
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| Project Period (FY) |
2008 – 2010
|
| Project Status |
Completed (Fiscal Year 2010)
|
| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2010: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2009: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2008: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
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| Keywords | 肝炎ウイルス / 肝細胞癌 / 生活習慣 / 炎症 / インスリン抵抗性 / コホート内症例対照研究 / 放射線被曝 / 酸化ストレス / 肝線維化 |
|---|
| Research Abstract |
We examined impact of hepatitis virus infection, radiation, as well as lifestyle on risk of hepatocellular carcinoma (HCC) and biomarkers contributing to increased risk of HCC, using stored sera from a cohort of atomic bomb survivors. This study showed that radiation exposure contributed to increased risk of HCC, independently of hepatitis B and/or C virus infections, and that alcohol consumption, obesity, and smoking were each associated independently with increased risk of non-B, non-C HCC. Higher IL-6 levels contributed to increased risk of HCC irrespective of hepatitis virus infection.
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